2351-33-9

Basic information

• Product Name: 1,1-DICHLOROSILACYCLOBUTANE
• Synonyms: 1,1-dichloro-silacyclobutan;1,1-Dichlorosiletane;DICHLORTRIMETHYLENSILAN;CYCLOTRIMETHYLENEDICHLOROSILANE;1,1-DICHLOROSILACYCLOBUTANE;1,1-Dichloro-1-silacyclobutane;1,1-Dichlorosilacyclobutane,97%;1,1-Dichlorosilacyclobutane, 97% 5ML
• CAS NO: 2351-33-9
• Molecular Formula: C₃H₆Cl₂Si
• Molecular Weight: 141.07
• EINECS: 219-084-7
• Product Categories: Protecting and Derivatizing Reagents;Protection and Derivatization;Silicon-Based
• Mol File: 2351-33-9.mol
• Article Data: 15

Chemical Properties

• Melting Point: <0°C
• Boiling Point: 113-115 °C(lit.)
• Flash Point: 68 °F
• Appearance: clear colorless to slightly yellow liquid
• Density: 1.19 g/mL at 25 °C(lit.)
• Vapor Pressure: 15.8mmHg at 25°C
• Refractive Index: n20/D 1.464(lit.)
• Storage Temp.: Flammables area
• CAS DataBase Reference: 1,1-DICHLOROSILACYCLOBUTANE(CAS DataBase Reference)
• NIST Chemistry Reference: 1,1-DICHLOROSILACYCLOBUTANE(2351-33-9)
• EPA Substance Registry System: 1,1-DICHLOROSILACYCLOBUTANE(2351-33-9)

Safety Data

• Hazard Codes: C
• Statements: 14-34
• Safety Statements: 16-23-26-36/37/39-45
• RIDADR: UN 2988 4.3/PG 1
• WGK Germany: 3
• TSCA: Yes
• Hazardous Substances Data: 2351-33-9(Hazardous Substances Data)

Usage

Chemical Properties

clear colorless to slightly yellow liquid

InChI:InChI=1/C3H6Cl2Si/c4-6(5)2-1-3-6/h1-3H2

Upstream product

• 287-29-6 siletane 
• 142-28-9 1,3-Dichloropropane 
• 109-64-8 1,3-dibromo-propane 
• 10025-78-2 trichlorosilane 
• 13883-39-1 (3-bromopropyl)trichlorosilane 
• 2550-06-3 3-chloropropyltrichlorosilane 
• 141-57-1 n-propyltrichlorosilane 

Downstream Products

• 2295-12-7 1,1-dimethylsilacyclobutane 
• 22843-50-1 1,1,3,3,5,5-hexamethyl-d18-1,3,5-trisilacyclohexane 
• 39103-74-7 methyl-tris-trideuteriomethyl-silane 
• 76063-29-1 1,1,3,3-tetra(perdeuteromethyl)-1,3-disilacyclobutane 
• 76070-25-2 1,1-bis(trideuteriodimethyl)-1-silacyclobutane 
• 3944-09-0 1,1-diphenylsilacyclobutane 
• 3401-28-3 1-chloro-1-phenyl-1-silacyclobutane 
• 16538-69-5 1,1,3,3,5,5-hexachloro-1,3,5-trisilacyclohexane 
• 75-79-6 Methyltrichlorosilane 
• 74-85-1 ethene 
• 141-57-1 n-propyltrichlorosilane 
• 78818-97-0 1,1-Dichlor-1-silaethen 
• 2146-97-6 1,1,3,3-tetrachloro-1,3-disilacyclobutane 
• 34557-54-5 methane 

Relevant articles and documents

1,1-Diethynylsilacycloalkanes and propellanes based thereon

Previously unknown 1,1-diethylnylsilacycloalkanes (CH2)nSi(C=CH)2 (n = 3, 4) were prepared by the reaction of HC=CMgBr with 1,1-dichlorosilacycloalkanes (CH2)nSiCl2 (n = 3, 4). The reaction of (CH2)4Si(C=CMgBr)2 with (CH2)4SiCl2 in THF under conditions of high dilution gives cyclo(tetramethylene)-silethynes [(CH2)4SiC=C]4 with an admixture of cyclodi(tetramethylene)silethyne [(CH2)4SiC=C]2. The reaction of Me2Si(C=CSiMe2C=CMgBr)2 with (CH2)4SiCl2 was used to prepare 1,1,4,4,7,7-hexamelhyl-10,10-tetramethylene-1,4,4,10-tetrasilacyclododeca-2,5,8, 11-tetrayne.

Rhodium-Catalyzed Intermolecular Silylation of Csp?H by Silacyclobutanes

The signature reactivity of silacyclobutane (SCB) is their cycloaddition reactions with various π bonds. Recently, the first cases were disclosed where SCBs reacted with both Csp2?H and Csp3?H σ bonds in an intramolecular fashion. Herein, it is reported that SCB is also an efficient reagent for Csp?H bond silylation. Thus, rhodium-catalyzed intermolecular reactions between SCBs and terminal alkynes produced a series of symmetrical and unsymmetrical tetraorganosilicons bearing a Csp?Si functionality. Preliminary studies suggested that the reaction did not involve a cycloaddition pathway, but instead a direct activation of Csp?H bonds.

A kind of preparation method of the midbody of entecavir, and intermediate

The invention discloses Entecavir intermediates and a preparation method thereof. The preparation method of an Entecavir intermediate represented by a formula IV or IV' shown in descriptions comprises the following step of enabling a compound V to be subjected to amino protecting group and hydroxyl protecting group removal reaction in the presence of protonic acid in a solvent. The preparation method disclosed by the invention has the advantages that raw materials are cheap and are easily obtained, reaction conditions are mild, side reactions are few, the yield is high, the pollution to the environment is little, and the intermediates are easily purified and separated, so that the preparation method is applicable to industrial production.

Entecavir intermediate and its preparation method

The invention discloses an entecavir intermediate and a preparation method thereof. A provided preparation method for an entecavir intermediate compound 10 comprises the following steps: performing reducing reaction on an ester compound 11 in an organic solvent under the effect of a reducing agent, so as to obtain the compound 10. A provided preparation method for an entecavir intermediate compound 11 comprises the following steps: reacting a compound 12 with a hydroxyl protection reagent in an organic solvent in the presence of an acid to add a hydroxyl protection group, so as to obtain the compound 11. The preparation methods are cheap and easily available in raw materials, mild in reaction conditions, relatively high in product yield, good in atom economy, friendly to environment, and suitable for industrialized production.