2352-37-6

Basic information

• Product Name: 1,3,5-Triazine-2,4-diamine,6-chloro-N2,N4-bis(4-nitrophenyl)-
• Synonyms: 1,3,5-Triazine-2,4-diamine,6-chloro-N,N'-bis(4-nitrophenyl)- (9CI); s-Triazine, 2-chloro-4,6-bis(p-nitroanilino)-(6CI,7CI,8CI); 2-Chloro-4,6-bis(4-nitroanilino)-s-triazine;2-Chloro-4,6-bis(p-nitroanilino)-1,3,5-triazine;6-Chloro-N,N'-bis(4-nitrophenyl)-1,3,5-triazine-2,4-diamine
• CAS NO: 2352-37-6
• Molecular Formula: C15H10 Cl N7 O4
• Molecular Weight: 387.742
• Mol File: 2352-37-6.mol
• Article Data: 11

Chemical Properties

• Boiling Point: 660.8°Cat760mmHg
• Flash Point: 353.5°C
• Density: 1.637g/cm³
• CAS DataBase Reference: 1,3,5-Triazine-2,4-diamine,6-chloro-N2,N4-bis(4-nitrophenyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 1,3,5-Triazine-2,4-diamine,6-chloro-N2,N4-bis(4-nitrophenyl)-(2352-37-6)
• EPA Substance Registry System: 1,3,5-Triazine-2,4-diamine,6-chloro-N2,N4-bis(4-nitrophenyl)-(2352-37-6)

Safety Data

• Hazardous Substances Data: 2352-37-6(Hazardous Substances Data)

Upstream product

• 100-01-6 4-nitro-aniline 
• 2352-36-5 4,6-dichloro-N-(4-nitrophenyl)-1,3,5-triazin-2-amine 
• 108-77-0 1,3,5-trichloro-2,4,6-triazine 

Downstream Products

• 76479-25-9 N,N'-Bis-(4-nitro-phenyl)-N''-[1-phenyl-meth-(E)-ylidene]-[1,3,5]triazine-2,4,6-triamine 
• 942046-05-1 N²,N⁴-bis(4-nitrophenyl)-6-(piperazin-1-yl)-1,3,5-triazine-2,4-diamine 
• 1450982-32-7 6-(4-(2-((7-chloroquinolin-4-yl)amino)ethyl)piperazin-1-yl)-N²,N⁴-bis(4-nitrophenyl)-1,3,5-triazine-2,4-diamine 
• 1453805-43-0 4-(4,6-bis(4-nitrophenylamino)-1,3,5-triazin-2-yl)-N-(7-chloroquinolin-4-yl)piperazine-1-carbothioamide 
• 1419961-28-6 6-(4-benzylpiperazin-1-yl)-N₄,N₄-bis(4-nitrophenyl)-1,3,5-triazine-2,4-diamine 
• 1258254-41-9 C₂₄H₁₆N₁₀O₆S 
• 1084910-25-7 C₂₃H₁₈N₈O₄S₂ 
• 100882-09-5 N,N'-bis-(4-nitro-phenyl)-[1,3,5]triazine-2,4,6-triamine 
• 100033-25-8 Sodium; 4,6-bis-(4-nitro-phenylamino)-[1,3,5]triazin-2-olate 
• 100033-21-4 C₁₆H₁₀N₉O₄^(1-)*Na⁽¹⁺⁾ 
• 84688-96-0 4-[4,6-Bis-(4-nitro-phenylamino)-[1,3,5]triazin-2-ylamino]-benzoic acid methyl ester 
• 96540-28-2 N,N'-Bis-(4-nitro-phenyl)-6-prop-2-ynyloxy-[1,3,5]triazine-2,4-diamine 

Relevant articles and documents

Design, synthesis, anticancer, antibacterial, and antifungal evaluation of 4-aminoquinoline-1,3,5-triazine derivatives

A series of 4-aminoquinoline 1,3,5-triazine derivatives were synthesized and evaluated for anticancer activity against cancer cell lines HeLa, MCF-7, HL-60, HepG2 where these derivatives exert significant anticancer activity. The molecules found nontoxic against MCF-12A. The molecules also showed potent inhibition of EGFR-TK as compared to eroltinib in enzyme-based assay. The newly synthesized derivatives were screened for their in vitro antibacterial and antifungal activity against Bacillus subtilis, Bacillus cereus, Staphylococcus aureus, Proteus vulgaris, Escherichia coli, Pseudomonas aeruginosa and Candida albicans, Aspergillus niger, Aspergillus fumigatus using cefixime and fluconazole as standard. Antibacterial screening results suggest that compound 7c showed potent activity against S. aureus, P. aeruginosa, and P. vulgaris. In antifungal screening, compound 7b showed significant activity against A. niger, A. fumigatus and moderate activity against C. albicans.

Discovery of novel 1,3,5-triazine-thiazolidine-2,4-diones as dipeptidyl peptidase-4 inhibitors with antibacterial activity targeting the S1 pocket for the treatment of type 2 diabetes

A novel series of 1,3,5-triazine-thiazolidine-2,4-diones was synthesized and characterized by a number of analytical and spectroscopic techniques. The molecules were screened for the in vitro inhibition of dipeptidyl peptidase-4 and compound 7a showed the most prominent inhibition with IC50 = 6.25 μM. The other compounds showed considerable inhibition (IC50 = 12.11-49.21 μM). Docking studies indicated that the lipophilic thiazolidine-2,4-dione fragment of ligand 7a was oriented towards the tight lipophilic cavity of the S1 pocket of the active site formed by residues such as Tyr631, Val656, Trp659, Tyr662, Tyr666 and Val711 via the formation of H-bonds with Tyr547. One of the amines present on the wings of the triazine formed a hydrogen bond with Glu205, a vital residue for the N-terminal recognition site with an efficient CDOCKER interaction energy. In a bacterial inhibition study, the entire set of compounds showed excellent activity and, in some instances, were found to be equipotent to the cefixime used as a standard.

Antimalarial activity and docking studies of novel bi-functional hybrids derived from 4-aminoquinoline and 1,3,5-triazine against wild and mutant malaria parasites as pf-DHFR inhibitor

Bi-functional conjugates comprised of 4-aminoquinoline and 1,3,5-triazine were synthesized through facile synthetic routes. These compounds were rigorously screened for determination of their antimalarial activity against wild and mutant cultured Plasmodium falciparum. The results disclosed that the conjugates have considerable antimalarial activity against both wild and mutant parasites with marked variation on changing the pattern of substitutions. The observed activity profiles were additionally substantiated by docking studies on both wild and quadruple mutant P. falciparum dihydrofolate reductase thymidylate synthase (pf-DHFR-TS).