2365-40-4Relevant articles and documents
THE SYNTHESIS OF COMPOUNDS POSSESSING KINETIN ACTIVITY. THE USE OF A
LEONARD,FUJI
, p. 73 - 75 (1964)
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CYTOKININS IN IMMATURE SEEDS OF DOLICHOS LABLAB
Yokota, Takao,Ueda, Junichi,Takahasi, Nobutaka
, p. 683 - 686 (1981)
Key Word Index - Dolichos lablab; Leguminoasae; cytokins; trans-zeatin; ribosyl-trans-zeatin; ribosyl-cis-zeatin; glucosyl-trans-zeatin; glucosyl ribosyl-trans-zeatin. Five cytokinins, trans-zeatin, 9-β-D-ribofuranosyl-trans-zeatin, 9-β-D-ribofuranosyl-cis-zeatin, 6-(trans-4-O-β-D-glucopyranosyl-3-methyl-2-butenylamino)purine and 6-(trans-4-O-β-D-glucopyranosyl-3-methyl-2-butenylamino)-9-β-D-ribofuranosylpurine were identified from immature seeds of Dolichos lablab.
Method for synthesizing adenine and derivatives thereof
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Paragraph 0051; 0052, (2017/07/19)
The invention discloses a method for synthesizing adenine and derivatives thereof. The method comprises the steps: firstly, subjecting diethyl malonate and dimethyl dioxirane to an oxidation reaction, so as to obtain 2-hydroxyldiethyl malonate; then, carrying out an ammonolysis reaction with ammonia water, so as to obtain 2-hydroxyl malonamide; then, carrying out a cyclization reaction with trimethyl orthoformate, so as to obtain 5-hydroxyl pyrimid-4,6-(1H,5H)-dione; then, carrying out a chlorination reaction with phosgene, so as to obtain 4,5,6-trichloropyrimidine; then, carrying out a cyclization reaction with formamidine hydrochloride, so as to obtain 4-chloro-1H-pyrazol[3, 4-d]pyrimidine; finally, carrying out an ammoniation reaction with ammonia water or an amine compound in the presence of triethylamine, thereby obtaining the adenine and derivatives thereof. According to the method, the raw materials are moderately-priced and readily available, the reaction conditions are mild, the reaction process is safe, the requirements on production equipment are low, particularly, the environmental pollution is light, and the yield is relatively high, so that the method is applicable to industrial large-scale production.
Chemical modification of the plant isoprenoid cytokinin N6-isopentenyladenosine yields a selective inhibitor of human enterovirus 71 replication
Tararov, Vitali I.,Tijsma, Aloys,Kolyachkina, Svetlana V.,Oslovsky, Vladimir E.,Neyts, Johan,Drenichev, Mikhail S.,Leyssen, Pieter,Mikhailov, Sergey N.
, p. 406 - 413 (2015/05/04)
In this study, we demonstrate that N6-isopentenyladenosine, which essentially is a plant cytokinin-like compound, exerts a potent and selective antiviral effect on the replication of human enterovirus 71 with an EC50 of 1.0 ± 0.2 mM and a selectivity index (SI) of 5.7. The synthesis of analogs with modification of the N6-position did not result in a lower EC50 value. However, in particular with the synthesis of N6-(5-hexene-2-yne-1-yl)adenosine (EC50 = 4.3 ± 1.5 mM), the selectivity index was significantly increased: because of a reduction in the adverse effect of this compound on the host cells, an SI 101 could be calculated. With this study, we for the first time provide proof that a compound class that is based on the plant cytokinin skeleton offers an interesting starting point for the development of novel antivirals against mammalian viruses, in the present context in particular against enterovirus 71.