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Cas Database

23778-52-1

23778-52-1

Identification

  • Product Name:3,6,9,12,15-Pentaoxahexadecan-1-ol

  • CAS Number: 23778-52-1

  • EINECS:245-874-6

  • Molecular Weight:252.308

  • Molecular Formula: C11H24O6

  • HS Code:2909499000

  • Mol File:23778-52-1.mol

Synonyms:2,5,8,11,14-Pentaoxahexadecan-16-ol(6CI,7CI,8CI,9CI);Ethanol, 2-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]-(7CI);3,6,9,12,15-Pentaoxahexadecanol;Methoxypentaethylene glycol;Pentaethylene glycol methyl ether;Pentaethylene glycol, monomethyl ether;

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Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

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  • Manufacture/Brand:TCI Chemical
  • Product Description:Pentaethylene Glycol Monomethyl Ether >96.0%(GC)
  • Packaging:5g
  • Price:$ 521
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  • Manufacture/Brand:TCI Chemical
  • Product Description:Pentaethylene Glycol Monomethyl Ether >96.0%(GC)
  • Packaging:1g
  • Price:$ 159
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  • Manufacture/Brand:purepeg
  • Product Description:Pentaethylene Glycol Monomethyl Ether min.97%
  • Packaging:5 g
  • Price:$ 229
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  • Manufacture/Brand:Crysdot
  • Product Description:2,5,8,11,14-Pentaoxahexadecan-16-ol 95%
  • Packaging:25g
  • Price:$ 533
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  • Manufacture/Brand:Crysdot
  • Product Description:2,5,8,11,14-Pentaoxahexadecan-16-ol 95%
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  • Price:$ 316
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  • Manufacture/Brand:chempep
  • Product Description:mPEG11-NH2 >=95%
  • Packaging:5g
  • Price:$ 1388
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  • Manufacture/Brand:chempep
  • Product Description:mPEG5-OH >=95%
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  • Manufacture/Brand:chempep
  • Product Description:mPEG5-OH >=95%
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  • Manufacture/Brand:chempep
  • Product Description:mPEG11-NH2 >=95%
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  • Manufacture/Brand:Chem-Impex
  • Product Description:Pentaethyleneglycolmonomethylether,≥96%(GC) ≥96%(GC)
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Relevant articles and documentsAll total 18 Articles be found

Engineering Nanoparticulate Organic Photocatalysts via a Scalable Flash Nanoprecipitation Process for Efficient Hydrogen Production

Guo, Zhiqian,Wu, Yongzhen,Yu, Miaojie,Zhang, Weiwei,Zhu, Weihong

, p. 15590 - 15597 (2021)

Directly converting sunlight into hydrogen fuels using particulate photocatalysts represents a sustainable route for clean energy supply. Organic semiconductors have emerged as attractive candidates but always suffer from optical and exciton recombination losses with large exciton “dead zone” inside the bulk material, severely limiting the catalytic performance. Herein, we demonstrate a facile strategy that combines a scalable flash nanoprecipitation (FNP) method with hydrophilic soluble polymers (PC-PEG5 and PS-PEG5) to prepare highly efficient nanosized photocatalysts without using surfactants. Significantly, a 70-fold enhancement of hydrogen evolution rate (HER) is achieved for nanosized PC-PEG5, and the FNP-processed PS-PEG5 shows a peak HER rate of up to 37.2 mmol h?1 g?1 under full-spectrum sunlight irradiation, which is among the highest results for polymer photocatalysts. A scaling-up production of nanocatalyst is demonstrated with the continuously operational FNP.

Hybrids of Small-Molecule CD4 Mimics with Polyethylene Glycol Units as HIV Entry Inhibitors

Kobayakawa, Takuya,Tsuji, Kohei,Konno, Kiju,Himeno, Ai,Masuda, Ami,Yang, Tingting,Takahashi, Kohei,Ishida, Yusuke,Ohashi, Nami,Kuwata, Takeo,Matsumoto, Kaho,Yoshimura, Kazuhisa,Sakawaki, Hiromi,Miura, Tomoyuki,Harada, Shigeyoshi,Matsushita, Shuzo,Tamamura, Hirokazu

supporting information, p. 1481 - 1496 (2021/02/27)

CD4 mimics are small molecules that inhibit the interaction of gp120 with CD4. We have developed several CD4 mimics. Herein, hybrid molecules consisting of CD4 mimics with a long alkyl chain or a PEG unit attached through a self-cleavable linker were synthesized. In anti-HIV activity, modification with a PEG unit appeared to be more suitable than modification with a long alkyl chain. Thus, hybrid molecules of CD4 mimics, with PEG units attached through an uncleavable linker, were developed and showed high anti-HIV activity and low cytotoxicity. In investigation of pharmacokinetics in a rhesus macaque, a hybrid compound had a more effective PK profile than that of the parent compound, and intramuscular injection was a more useful administration route to maintain the high blood concentration of the CD4 mimic than intravenous injection. The presented hybrid molecules of CD4 mimics with a PEG unit would be practically useful when combined with a neutralizing antibody.

Designing Nonfullerene Acceptors with Oligo(Ethylene Glycol) Side Chains: Unraveling the Origin of Increased Open-Circuit Voltage and Balanced Charge Carrier Mobilities

Cui, Junjie,Park, Jung-Hwa,Kim, Dong Won,Choi, Min-Woo,Chung, Hae Yeon,Kwon, Oh Kyu,Kwon, Ji Eon,Park, Soo Young

supporting information, p. 2481 - 2488 (2021/07/26)

Despite the recent rapid development of organic solar cells (OSCs), the low dielectric constant (?r=3–4) of organic semiconducting materials limits their performance lower than inorganic and perovskite solar cells. In this work, we introduce oligo(ethylene glycol) (OEG) side chains into the dicyanodistyrylbenzene-based non-fullerene acceptors (NIDCS) to increase its ?r up to 5.4. In particular, a NIDCS acceptor bearing two triethylene glycol chains (NIDCS-EO3) shows VOC as high as 1.12 V in an OSC device with a polymer donor PTB7, which is attributed to reduced exciton binding energy of the blend film. Also, the larger size grain formation with well-ordered stacking structure of the NIDCS-EO3 blend film leads to the increased charge mobility and thus to the improved charge mobility balance, resulting in higher JSC, FF, and PCE in the OSC device compared to those of a device using the hexyl chain-based NIDCS acceptor (NIDCS-HO). Finally, we fabricate NIDCS-EO3 devices with various commercial donors including P3HT, DTS-F, and PCE11 to show higher photovoltaic performance than the NIDCS-HO devices, suggesting versatility of NIDCS-EO3.

Enzyme-Mediated Directional Transport of a Small-Molecule Walker with Chemically Identical Feet

Martin, Christopher J.,Lee, Alan T. L.,Adams, Ralph W.,Leigh, David A.

supporting information, p. 11998 - 112002 (2017/09/07)

We describe a small-molecule "walker" that uses enzyme catalysis to discriminate between the relative positions of its "feet" on a track and thereby move with net directionality. The bipedal walker has identical carboxylic acid feet, and "steps" along an isotactic hydroxyl-group-derivatized polyether track by the formation/breakage of ester linkages. Lipase AS catalyzes the selective hydrolysis of the rear foot of macrocyclized walkers (an information ratchet mechanism), the rear foot producing an (R)-stereocenter at its point of attachment to the track. If the hydrolyzed foot reattaches to the track in front of the bound foot it forms an (S)-stereocenter, which is resistant to enzymatic hydrolysis. Only macrocyclic walker-track conjugates are efficiently hydrolyzed by the enzyme, leading to high processivity of the walker movement along the track. Conventional chemical reagents promote formation of the ester bonds between the walker and the track. Iterative macrocyclization and hydrolysis reactions lead to 68% of walkers taking two steps directionally along a three-foothold track.

Gold nanoparticles generated by thermolysis of "all-in-one" gold(i) carboxylate complexes

Tuchscherer,Schaarschmidt,Schulze,Hietschold,Lang

scheme or table, p. 2738 - 2746 (2012/04/10)

Consecutive synthesis methodologies for the preparation of the gold(i) carboxylates [(Ph3P)AuO2CCH2(OCH 2CH2)nOCH3] (n = 0-6) (6a-g) are reported, whereby selective mono-alkylation of diols HO(CH2CH 2O)nH (n = 0-6), Williamson ether synthesis and metal carboxylate (Ag, Au) formation are the key steps. Single crystal X-ray diffraction studies of 6a (n = 0) and 6b (n = 1) were carried out showing that the P-Au-O unit is essentially linear. These compounds were applied in the formation of gold nanoparticles (NP) by a thermally induced decomposition process and hence the addition of any further stabilizing and reducing reagents, respectively, is not required. The ethylene glycol functionalities, providing multiple donating capabilities, are able to stabilise the encapsulated gold colloids. The dependency of concentration, generation time and ethylene glycol chain lengths on the NP size and size distribution is discussed. Characterisation of the gold colloids was performed by TEM, UV/Vis spectroscopy and electron diffraction studies revealing that Au NP are formed with a size of 3.3 (±0.6) to 6.5 (±0.9) nm in p-xylene with a sharp size distribution. Additionally, a decomposition mechanism determined by TG-MS coupling experiments of the gold(i) precursors is reported showing that 1 st decarboxylation occurs followed by the cleavage of the Au-PPh 3 bond and finally release of ethylene glycol fragments to give Au-NP and the appropriate organics. The Royal Society of Chemistry 2012.

Process route upstream and downstream products

Process route

Pentaethylene glycol
4792-15-8

Pentaethylene glycol

methyl iodide
74-88-4

methyl iodide

3,6,9,12,15-pentaoxahexadecanol
23778-52-1,95507-80-5

3,6,9,12,15-pentaoxahexadecanol

pentaglyme
1191-87-3

pentaglyme

Conditions
Conditions Yield
With sodium hydride; In N,N-dimethyl-formamide;
5.5%
59%
4-amino-6-mercapto-pyrazolo(3,4-d)pyrimidine
23771-52-0

4-amino-6-mercapto-pyrazolo(3,4-d)pyrimidine

Conditions
Conditions Yield
4-Mercapto-pyrazolopyrimidin, NH3;
4,6-Dimercapto-Verb., NH3;
/BRN= 516935/,NH3;
18,18-diisopropyl-19-methyl-2,5,8,11,14,17-hexaoxa-18-silaicosane

18,18-diisopropyl-19-methyl-2,5,8,11,14,17-hexaoxa-18-silaicosane

3,6,9,12,15-pentaoxahexadecanol
23778-52-1,95507-80-5

3,6,9,12,15-pentaoxahexadecanol

Conditions
Conditions Yield
With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 16h; Inert atmosphere;
98%
With tetrabutyl ammonium fluoride; In tetrahydrofuran; at 20 ℃; for 16h; Inert atmosphere;
95%
Tetraethylene glycol
112-60-7

Tetraethylene glycol

2-Bromoethyl methyl ether
6482-24-2

2-Bromoethyl methyl ether

3,6,9,12,15-pentaoxahexadecanol
23778-52-1,95507-80-5

3,6,9,12,15-pentaoxahexadecanol

Conditions
Conditions Yield
Tetraethylene glycol; With potassium tert-butylate; In tetrahydrofuran; at 20 ℃; for 0.5h;
2-Bromoethyl methyl ether; In tetrahydrofuran; at 20 ℃;
35%
2-(2-(2-methoxyethoxy)ethoxy)ethyl p-toluenesulfonate
62921-74-8,518012-62-9,58320-73-3

2-(2-(2-methoxyethoxy)ethoxy)ethyl p-toluenesulfonate

diethylene glycol
111-46-6

diethylene glycol

3,6,9,12,15-pentaoxahexadecanol
23778-52-1,95507-80-5

3,6,9,12,15-pentaoxahexadecanol

Conditions
Conditions Yield
With sodium hydride; In tetrahydrofuran; at 80 ℃; for 15h; Inert atmosphere;
100%
With sodium hydride; In tetrahydrofuran; for 24h; Reflux;
72.1%
diethylene glycol; With sodium; at 100 ℃;
2-(2-(2-methoxyethoxy)ethoxy)ethyl p-toluenesulfonate; at 100 ℃; Further stages.;
Pentaethylene glycol
4792-15-8

Pentaethylene glycol

3,6,9,12,15-pentaoxahexadecanol
23778-52-1,95507-80-5

3,6,9,12,15-pentaoxahexadecanol

Conditions
Conditions Yield
Multi-step reaction with 3 steps
1: aq. NaOH
2: aq. NaOH
3: 97 percent / H2 / Pd
With sodium hydroxide; hydrogen; palladium;
Multi-step reaction with 3 steps
1: 1H-imidazole / dichloromethane / 18 h / 20 °C / Inert atmosphere
2: sodium hydride / tetrahydrofuran; mineral oil / 20 h / 0 - 20 °C / Inert atmosphere
3: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere
With 1H-imidazole; tetrabutyl ammonium fluoride; sodium hydride; In tetrahydrofuran; dichloromethane; mineral oil;
Multi-step reaction with 3 steps
1.1: 1H-imidazole / dichloromethane / 18 h / 20 °C / Inert atmosphere
2.1: sodium hydride / mineral oil; tetrahydrofuran / 0 °C / Inert atmosphere
2.2: 20 h / 0 - 20 °C / Inert atmosphere
3.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere
With 1H-imidazole; tetrabutyl ammonium fluoride; sodium hydride; In tetrahydrofuran; dichloromethane; mineral oil;
3,3-diisopropyl-2-methyl-4,7,10,13,16-pentaoxa-3-silaoctadecan-18-ol

3,3-diisopropyl-2-methyl-4,7,10,13,16-pentaoxa-3-silaoctadecan-18-ol

3,6,9,12,15-pentaoxahexadecanol
23778-52-1,95507-80-5

3,6,9,12,15-pentaoxahexadecanol

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: sodium hydride / tetrahydrofuran; mineral oil / 20 h / 0 - 20 °C / Inert atmosphere
2: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere
With tetrabutyl ammonium fluoride; sodium hydride; In tetrahydrofuran; mineral oil;
Multi-step reaction with 2 steps
1.1: sodium hydride / mineral oil; tetrahydrofuran / 0 °C / Inert atmosphere
1.2: 20 h / 0 - 20 °C / Inert atmosphere
2.1: tetrabutyl ammonium fluoride / tetrahydrofuran / 16 h / 20 °C / Inert atmosphere
With tetrabutyl ammonium fluoride; sodium hydride; In tetrahydrofuran; mineral oil;
2-[2-(2-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]tetrahydropyran
146395-16-6

2-[2-(2-{2-[2-(2-methoxyethoxy)ethoxy]ethoxy}ethoxy)ethoxy]tetrahydropyran

3,6,9,12,15-pentaoxahexadecanol
23778-52-1,95507-80-5

3,6,9,12,15-pentaoxahexadecanol

Conditions
Conditions Yield
With hydrogenchloride; methanol; In dichloromethane; for 3h; Heating;
58%
With hydrogenchloride; In ethanol; water; Heating;
With hydrogenchloride; In methanol; dichloromethane; Reflux;
triethylene glucol monomethyl ether
112-35-6,95507-80-5

triethylene glucol monomethyl ether

3,6,9,12,15-pentaoxahexadecanol
23778-52-1,95507-80-5

3,6,9,12,15-pentaoxahexadecanol

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1.1: NaOH / H2O; tetrahydrofuran / 0 °C
2.1: Na / 100 °C
2.2: 100 °C
With sodium hydroxide; sodium; In tetrahydrofuran; water;
Multi-step reaction with 2 steps
1: 47.4 g / NaH / paraffin; tetrahydrofuran / 1.) room temperature, 1.5 h, 2.) reflux, 24 h
2: 58 percent / conc. HCl, MeOH / CH2Cl2 / 3 h / Heating
With hydrogenchloride; methanol; sodium hydride; In tetrahydrofuran; dichloromethane; paraffin;
Multi-step reaction with 2 steps
1: triethylamine; dmap / dichloromethane / 8 h / 20 °C / Inert atmosphere
2: sodium hydride / tetrahydrofuran / 15 h / 80 °C / Inert atmosphere
With dmap; sodium hydride; triethylamine; In tetrahydrofuran; dichloromethane;
Multi-step reaction with 2 steps
1: pyridine / dichloromethane / 8 h / 20 °C
2: sodium hydride / tetrahydrofuran / 24 h / Reflux
With pyridine; sodium hydride; In tetrahydrofuran; dichloromethane;
1-benzyl-15-methoxy-pentaoxyethylene
155887-95-9

1-benzyl-15-methoxy-pentaoxyethylene

3,6,9,12,15-pentaoxahexadecanol
23778-52-1,95507-80-5

3,6,9,12,15-pentaoxahexadecanol

Conditions
Conditions Yield
With hydrogen; palladium;
97%

Global suppliers and manufacturers

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  • Amadis Chemical Co., Ltd.
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  • Shaanxi BLOOM TECH Co.,Ltd
  • Business Type:Lab/Research institutions
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  • Emails:sales@bloomtechz.com
  • Main Products:80
  • Country:China (Mainland)
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