238742-91-1

Basic information

• Product Name: 4-BROMO-2-(TRIFLUOROMETHOXY)PHENYL ISOTHIOCYANATE
• Synonyms: 4-BROMO-2-(TRIFLUOROMETHOXY)PHENYL ISOTHIOCYANATE;4-Bromo-2-(trifluoromethoxy)phenyl isothiocyanate 97%;4-Bromo-2-(trifluoromethoxy)phenylisothiocyanate97%;4-Bromo-1-isothiocyanato-2-(trifluoromethoxy)benzene
• CAS NO: 238742-91-1
• Molecular Formula: C₈H₃BrF₃NOS
• Molecular Weight: 298.08
• Product Categories: Phenyls & Phenyl-Het
• Mol File: 238742-91-1.mol

Chemical Properties

• Boiling Point: 282.3°Cat760mmHg
• Flash Point: 124.6°C
• Appearance: /
• Density: 1.66g/cm³
• Vapor Pressure: 0.00576mmHg at 25°C
• Refractive Index: 1.54
• CAS DataBase Reference: 4-BROMO-2-(TRIFLUOROMETHOXY)PHENYL ISOTHIOCYANATE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-BROMO-2-(TRIFLUOROMETHOXY)PHENYL ISOTHIOCYANATE(238742-91-1)
• EPA Substance Registry System: 4-BROMO-2-(TRIFLUOROMETHOXY)PHENYL ISOTHIOCYANATE(238742-91-1)

Safety Data

• Hazard Codes: T
• Statements: 20/21/22-36/37/38-43
• Safety Statements: 26-36/37/39-36/37
• RIDADR: 2810
• Hazardous Substances Data: 238742-91-1(Hazardous Substances Data)

Usage

Uses

Used in Materials Science:
4-Bromo-2-(trifluoromethoxy)phenyl isothiocyanate is used as a building block or intermediate in the synthesis of various materials due to its unique chemical structure and reactivity.
Used in Pharmaceutical Research:
In pharmaceutical research, 4-Bromo-2-(trifluoromethoxy)phenyl isothiocyanate is used as a chemical probe or in the development of new drugs, potentially for its reactivity with biological targets or its incorporation into drug candidates.
Used in Chemical Synthesis:
4-Bromo-2-(trifluoromethoxy)phenyl isothiocyanate is used as a reagent in organic synthesis for the preparation of other complex organic molecules, taking advantage of its isothiocyanate moiety for reactions such as cycloadditions or nucleophilic additions.
Used in Analytical Chemistry:
4-BROMO-2-(TRIFLUOROMETHOXY)PHENYL ISOTHIOCYANATE may also be used in analytical chemistry as a derivatizing agent for the detection and analysis of certain types of molecules, given its reactive isothiocyanate group.

InChI:InChI=1/C8H3BrF3NOS/c9-5-1-2-6(13-4-15)7(3-5)14-8(10,11)12/h1-3H

Upstream product

• 175278-09-8 4-bromo-2-(trifluoromethoxy)aniline 

Downstream Products

• 1355959-98-6 C₁₂H₉BrF₃N₃O₃ 
• 1355959-60-2 C₁₄H₁₃BrF₃N₃O₃ 
• 1228245-60-0 C₈H₇BrF₃N₃OS 

Relevant articles and documents

Discovery of novel anti-angiogenesis agents. Part 6: Multi-targeted RTK inhibitors

Angiogenesis is modulated by a multitude of pro-angiogenic factors including VEGFR-2, Tie-2, and EphB4. Moreover, their crosstalk also had been well elaborated. We have identified several diarylurea-based VEGFR-2 inhibitors as potential anti-angiogenesis agents. As a continuation to our previous research, two series of diaryl malonamide and diaryl thiourea derivatives have been developed as multiplex VEGFR-2/Tie-2/EphB4 inhibitors. Interestingly, the biological evaluation indicated that several compounds bearing trifluoromethyl or trifluoromethoxyl exhibited promising multiplex inhibition against angiogenesis-related VEGFR-2, Tie-2, and EphB4. The representative compound (18a) displayed both potent multi-targeted RTK inhibition and considerable antiproliferative activities against human umbilical vein endothelial cells (EA.hy926). These results will contribute to the discovery of novel muti-targeted anti-angiogenesis agents.

Diarylthiourea compound with antitumor activity, and preparation method and application thereof

The invention provides a diarylthiourea compound with antitumor activity, and a preparation method and application thereof. The compound has a structural formula as described in the specification. In the structural formula, R1 and R2 are selected from the group consisting of a halogen group or a group formed by R1 and R2 together; and Ar is a nitrogen heterocyclic ring of pyridine, indazole or quinazoline. The compound provided by the invention has good inhibitory activity to VEGFR-2 kinase, so a signal channel induced by the VEGFR-2 kinase can be blocked through inhibition of the activity of the VEGFR-2 kinase, and proliferation and migration of tumor cells are inhibited; thus, the compound can be applied in preparation of antitumor drugs. Meanwhile, the preparation method for the compound has the following advantages: raw materials are easily available; reaction conditions are mild; the process of reaction is simple to operate; and used reagents are cheap.