240429-12-3

Basic information

• Product Name: 4-[(2,6-bis-tert-butoxycarbonylamino-hexanoylamino)-methyl]-cyclohexanecarboxylic acid
• Synonyms: 4-[(2,6-bis-tert-butoxycarbonylamino-hexanoylamino)-methyl]-cyclohexanecarboxylic acid
• CAS NO: 240429-12-3
• Molecular Weight: 485.621
• Mol File: 240429-12-3.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 4-[(2,6-bis-tert-butoxycarbonylamino-hexanoylamino)-methyl]-cyclohexanecarboxylic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[(2,6-bis-tert-butoxycarbonylamino-hexanoylamino)-methyl]-cyclohexanecarboxylic acid(240429-12-3)
• EPA Substance Registry System: 4-[(2,6-bis-tert-butoxycarbonylamino-hexanoylamino)-methyl]-cyclohexanecarboxylic acid(240429-12-3)

Safety Data

• Hazardous Substances Data: 240429-12-3(Hazardous Substances Data)

Upstream product

• 1197-18-8 trans-4-aminomethyl-cyclohexyl-carboxylic acid 
• 2483-46-7 Boc-Lys(Boc)-OH 

Downstream Products

• 240429-15-6 [5-({4-[(3-{4-[3-({4-[(2,6-bis-tert-butoxycarbonylamino-hexanoylamino)-methyl]-cyclohexylmethyl}-amino)-propyl]-piperazin-1-yl}-propylamino)-methyl]-cyclohexylmethyl}-carbamoyl)-5-tert-butoxycarbonylamino-pentyl]-carbamic acid tert-butyl ester 
• 240429-13-4 {5-tert-butoxycarbonylamino-5-[(4-formyl-cyclohexylmethyl)-carbamoyl]-pentyl}-carbamic acid tert-butyl ester 
• 240429-14-5 {5-tert-butoxycarbonylamino-5-[(4-hydroxymethyl-cyclohexylmethyl)-carbamoyl]-pentyl}-carbamic acid tert-butyl ester 

Relevant articles and documents

Synthesis of polyamine derivatives for the preparation of affinity chromatography columns for the search of new Trypanosoma cruzi targets

The most potent trypanocidal compound of a series of symmetrically substituted 1,4-bis(3-aminopropylpiperazines) which displayed an IC50 value of 5 μM on Trypanosoma cruzi trypomastigotes, was inactive on trypanothione reductase. Two derivatives 6 and 12 of this compound, one symmetrical and one dissymetrical, were synthesized via a reductive amination reaction, to prepare affinity chromatography columns, which allowed us to isolate three parasitic proteins. Among these, the major ligand 6- and 12-binding protein having an apparent molecular weight of 52 kDa has been identified as the thiol-disulfide oxido-reductase Tc52, previously characterized in Trypanosoma cruzi.