24059-71-0

Basic information

• Product Name: 1-(2-Methylphenyl)-2-pyrrolizinone
• Synonyms: 1-(2-Methylphenyl)-2-pyrrolizinone
• CAS NO: 24059-71-0
• Molecular Formula: C₁₁H₁₃NO
• Molecular Weight: 175.23
• Mol File: 24059-71-0.mol
• Article Data: 15

Chemical Properties

• Melting Point: 44-47 °C
• Boiling Point: 307°C at 760 mmHg
• Flash Point: 193.1°C
• Appearance: /
• Density: 1.117g/cm³
• Vapor Pressure: 0.000745mmHg at 25°C
• Refractive Index: 1.569
• PKA: 1.22±0.20(Predicted)
• CAS DataBase Reference: 1-(2-Methylphenyl)-2-pyrrolizinone(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-Methylphenyl)-2-pyrrolizinone(24059-71-0)
• EPA Substance Registry System: 1-(2-Methylphenyl)-2-pyrrolizinone(24059-71-0)

Safety Data

• Hazardous Substances Data: 24059-71-0(Hazardous Substances Data)

Usage

General Description

1-(2-Methylphenyl)-2-pyrrolizinone is a chemical compound with the molecular formula C13H11NO. It is an organic compound that belongs to the class of pyrrolizidinones, containing a pyrrolizidinone moiety. This chemical has potential applications in the pharmaceutical industry, as it may have biological activities or therapeutic properties. It is important for its role as a building block for the synthesis of various pharmaceutical compounds and may serve as a precursor for the development of new drugs. Further research and studies are needed to understand its specific properties and potential applications in the pharmaceutical field.

InChI:InChI=1/C11H13NO/c1-9-5-2-3-6-10(9)12-8-4-7-11(12)13/h2-3,5-6H,4,7-8H2,1H3

Upstream product

• 96-48-0 4-butanolide 
• 95-53-4 o-toluidine 
• 616-45-5 2-pyrrolidinon 
• 615-37-2 ortho-methylphenyl iodide 
• 110-63-4 Butane-1,4-diol 
• 4635-59-0 4-Chlorobutanoyl chloride 
• 624-31-7 4-tolyl iodide 
• 1036030-62-2 [bis(1,10-phenanthroline)copper][bis(pyrrolidin-2-one)copper] 
• 6729-60-8 tris(2-methylphenyl)bismuth dichloride 
• 41790-76-5 N-(4-Chlorbutyryl)-o-toluidin 
• 4641-57-0 1-phenylpyrrolidin-2-one 
• 15924-70-6 Cyclopropancarbonsaeure-o-toluidid 

Downstream Products

• 41790-73-2 2-(2-oxopyrrolidin-1-yl)-benzoic acid 
• 860361-32-6 1-(2-methyl-4-nitro-phenyl)-pyrrolidin-2-one 
• 13691-29-7 1-(4-amino-2-methyl-phenyl)-pyrrolidin-2-one 
• 186667-91-4 diethyl [1-(2-methylphenyl)pyrrolidin-2-ylidene]malonate 
• 208646-52-0 N-(2-methylphenyl)-6-aminohexan-3-one 
• 186667-86-7 N-(2-methylphenyl)pyrrolidine-2-thione 
• 208646-53-1 3-methoxy-2-oxo-4-propionyl-1-(2-methylphenyl)-1,2,5,6-tetrahydropyridine 
• 162142-33-8 3-hydroxy-2-oxo-4-propionyl-1-(2-methylphenyl)-1,2,5,6-tetrahydropyridine 

Relevant articles and documents

Conformational Analysis of Rotational Barriers in N-Arylpyrrolidin-2-ones

The structures of N-phenylpyrrolidin-2-one and the three isomeric N-tolylpyrrolidin-2-ones have been studied by single-crystal X-ray diffraction, as a basis for the conformational analysis of the barrier to rotation around the single bond between the rings.Force-field simulation of the molecular structure is consistent with a rotational barrier of 7 kJ mol-1.Crystal data: N-phenylpyrrolidin-2-one, orthorhombic, Pbca, a = 14.114 (3), b = 6.879 (4), c = 17.386 (5) Angstroem, R = 0.059 for 1110 unique reflections o4?(Fo)>; N-(2-methylphenyl)pyrrolidin-2-one,orthorhombic, Pbca, a = 16.999 (4), b = 16.411 (2), c = 7.008 (2) Angstroem, R = 0.077 for 1479 unique reflections o4?(Fo)>; N-(3-methylphenyl)pyrrolidin-2-one, monoclinic, P21/c, a = 10.411 (2), b = 7.645 (2), c = 12.782 (1) Angstroem, β = 110.32 (1) deg, R = 0.065 for 1641 unique reflections o4?(Fo)>; N-(4-methylphenyl)pyrrolidin-2-one, orthorhombic, P212121, a = 7.668 (2), b = 10.804 (2), c = 11.456 (1) Angstroem, R = 0.054 for 1155 unique reflections o4?(Fo)>.

Aluminium Chloride-Mediated Synthesis of 1-Chloro-2,2,2-Trifluoroethylidene-Substituted Pyrrolidones

An aluminium chloride-mediated cascade reaction between pyrrolidones and trifluoroacetic anhydride is reported. Functionally diverse 1-chloro-2,2,2-trifluoroethylidene-substituted pyrrolidones were obtained in moderate to high yields through electrophilic trifluoroacetylation, nucleophilic chlorination, and elimination. This procedure has a wide scope, good functional-group tolerance and the reaction conditions are amenable to scale up. Additionally the obtained 1-chloro-2,2,2-trifluoroethylidene products can be applied to further functionalization as trifluoromethyl-containing building blocks. Some of the title compounds showed fungicidal activity against cucumber downy mildew (CDM). (Figure presented.).

An Annulative Synthetic Strategy for Building Triphenylene Frameworks by Multiple C?H Bond Activations

C?H activation is a versatile tool for appending aryl groups to aromatic systems. However, heavy demands on multiple catalytic cycle operations and site-selectivity have limited its use for graphene segment synthesis. A Pd-catal- yzed one-step synthesis of functionalized triphenylene frameworks is disclosed, which proceeds by 2- or 4-fold C?H arylation of unactivated benzene derivatives. A Pd2(dibenzylideneacetone)3 catalytic system, using cyclic diaryliodonium salts as π-extending agents, leads to site-selective inter- and intramolecular tandem arylation sequences. Moreover, N-substituted triphenylenes are applied to a field-effect transistor sensor for rapid, sensitive, and reversible alcohol vapor detection.