24303-08-0

Basic information

• Product Name: 3-Pyridinecarboxamide, N-(2-phenylethyl)-
• Synonyms: F3153-0436;N-(2-phenylethyl)nicotinamide;Nicotinsaeure-phenaethylamid;Nicotinsaeure-phenethylamid;N-Phenethyl-nicotinamide;nicotinic acid phenethylamide
• CAS NO: 24303-08-0
• Molecular Formula: C14H14N2O
• Molecular Weight: 226.278
• Mol File: 24303-08-0.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: 3-Pyridinecarboxamide, N-(2-phenylethyl)-(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Pyridinecarboxamide, N-(2-phenylethyl)-(24303-08-0)
• EPA Substance Registry System: 3-Pyridinecarboxamide, N-(2-phenylethyl)-(24303-08-0)

Safety Data

• Hazardous Substances Data: 24303-08-0(Hazardous Substances Data)

Upstream product

• 59-67-6 nicotinic acid 
• 64-04-0 phenethylamine 
• 10400-19-8 3-pyridinecarbonyl chloride 
• 156-28-5 2-phenylethylamine hydrochloride 
• 20260-53-1 pyridine-3-carbonyl chloride hydrochloride 
• 98-92-0 nicotinamide 
• 500-22-1 3-pyridinecarboxaldehyde 
• 100-42-5 styrene 
• 614-18-6 3-pyridinecarboxylic acid ethyl ester 

Downstream Products

• 1233189-03-1 3-phenethylcarbamoyl-1-[(3-p-tolylcarbamoyl-phenylcarbamoyl)-methyl]-pyridinium chloride 
• 1233189-04-2 3-phenethylcarbamoyl-1-[(3-m-tolylcarbamoyl-phenylcarbamoyl)-methyl]-pyridinium chloride 
• 1233189-05-3 1-{[3-(4-chloro-phenylcarbamoyl)-phenylcarbamoyl]-methyl}-3-phenethylcarbamoyl-pyridinium chloride 
• 1233189-06-4 1-{[3-(4-methoxy-phenylcarbamoyl)-phenylcarbamoyl]-methyl}-3-phenethylcarbamoyl-pyridinium chloride 
• 1233189-07-5 1-[(3-benzoylamino-phenylcarbamoyl)-methyl]-3-phenethylcarbamoyl-pyridinium chloride 
• 1233189-08-6 1-{[3-(4-methyl-benzoylamino)-phenylcarbamoyl]-methyl}-3-phenethylcarbamoyl-pyridinium; chloride 
• 1233189-09-7 3-phenethylcarbamoyl-1-{[3-(toluene-4-sulfonylamino)-phenylcarbamoyl]-methyl}-pyridinium chloride 
• 106590-21-0 3-(5-phenyl-oxazol-2-yl)-pyridine 
• 84254-40-0 1-benzyl-3-(N-phenethylcarbamoyl)pyridinium bromide 
• 856212-18-5 N-phenethylpiperidine-3-carboxamide 
• 84254-38-6 1-methyl-3-(N-phenethylcarbamoyl)pyridinium iodide 

Relevant articles and documents

Base-Mediated Anti-Markovnikov Hydroamidation of Vinyl Arenes with Arylamides

We investigated a base-promoted protocol for the intermolecular anti-Markovnikov hydroamidation of vinyl arenes with arylamides to furnish the arylethylbenzamides with excellent chemo- and regioselectivity. The reaction tolerates an extensive variety of functional groups and has been successfully extended with electronically varied handles, aminobenzamides, electron-rich/electron-deficient heterocyclic amides, and vinyl arenes to afford the hydroamidated products. Excellent chemoselectivity was observed for the amide group over amine. The proposed mechanism and vital role of the solvent was well supported by deuterium labeling studies and control experiments.

Microwave-promoted direct amidation of unactivated esters catalyzed by heteropolyanion-based ionic liquids under solvent-free conditions

Abstract A simple and efficient procedure for the synthesis of amides directly from unactivated esters and amines catalyzed by heteropolyanion-based ionic liquids under microwave-promoted and solvent-free conditions has been reported. The practical protocol was found to be compatible with different structurally diverse substrates. Moderate to excellent yields, solvent-free media, and operational simplicity are the main highlights. Furthermore, the heteropolyanion-based ionic liquids were easily reusable for this amidation.

Microwave-assisted heteropolyanion-based ionic liquids catalyzed transamidation of non-activated carboxamides with amines under solvent-free conditions

An environmentally benign and highly efficient protocol for the transamidation of non-activated carboxamides with amines using heteropolyanion-based ionic liquids as catalysts under microwave-assisted and solvent-free conditions has been developed. As evaluated by the reactions of a structurally diverse set of amides and amines, the scope and utility of the transamidation proved to be quite general. Operational simplicity, solvent-free media, the potential reusability of catalysts and wide functional group tolerance are attractive features. This method provides a much improved protocol over the existing methods.