243858-66-4

Basic information

• Product Name: tert-butyl 3-(hydroxymethyl)-3,4-dihydro-1H-isoquinoline-2-carboxylate
• Synonyms: tert-butyl 3-(hydroxymethyl)-3,4-dihydro-1H-isoquinoline-2-carboxylate;tert-butyl 3-(hydroxymethyl)-3,4-dihydroisoquinoline-2(1H)-carboxylate;2-Boc-1,3,4-trihydro-3-isoquinolinemethanol
• CAS NO: 243858-66-4
• Molecular Formula: C15H21NO3
• Molecular Weight: 263.34
• Mol File: 243858-66-4.mol
• Article Data: 4

Chemical Properties

• Appearance: /
• CAS DataBase Reference: tert-butyl 3-(hydroxymethyl)-3,4-dihydro-1H-isoquinoline-2-carboxylate(CAS DataBase Reference)
• NIST Chemistry Reference: tert-butyl 3-(hydroxymethyl)-3,4-dihydro-1H-isoquinoline-2-carboxylate(243858-66-4)
• EPA Substance Registry System: tert-butyl 3-(hydroxymethyl)-3,4-dihydro-1H-isoquinoline-2-carboxylate(243858-66-4)

Safety Data

• Hazardous Substances Data: 243858-66-4(Hazardous Substances Data)

Upstream product

• 63006-93-9 3-hydroxymethyl-1,2,3,4-tetrahydroisoquinoline 
• 140-29-4 phenylacetonitrile 
• 58632-95-4 2-(tert-Butoxycarbonyloxyimino)-2-phenylacetonitrile 
• 41994-51-8 1,2,3,4-tetrahydro-isoquinoline-3-carboxylic acid ; hydrochloride 
• 24424-99-5 di-tert-butyl dicarbonate 
• 151838-62-9 N-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3-carboxylic acid 

Downstream Products

• 104668-15-7 N-(tert-butoxycarbonyl)-1,2,3,4-tetrahydroisoquinoline-3(S)-carbaldehyde 

Relevant articles and documents

Investigations concerning the organolanthanide and group 3 metallocene-catalyzed cyclization-functionalization of nitrogen-containing dienes

Organolanthanide catalyzed cyclization-silylation of nitrogen-containing polyunsaturated systems allows access to core structures commonly found in naturally occurring alkaloids. Nitrogen-containing dienes with various substitution patterns were investigated. The method was most successful for substrates with terminal alkenes. Cyclization upon pendant 1,1-disubstituted olefins was not realized under various conditions. Interestingly, sterically hindered sulfonamides, which were previously believed to render the catalyst inactive, were actually compatible with the catalyst, thus affording the cyclized products after prolonged reaction times. Variations using fused ring systems were also investigated.

Tetrahydroisoquinolinealkanol derivatives and pharmaceutical compositions containing same

The present invention provides novel 1,2,3,4-tetrahydroisoquinoline carbamate and thiocarbamate derivatives represented by Formula I STR1 wherein: X1 and X2 are the same or different from each other and independently represent a a me