24476-55-9

Basic information

• Product Name: 4-phenyl-1-(p-tolylsulphonyl)piperidine-4-carbonitrile
• Synonyms: 4-phenyl-1-(p-tolylsulphonyl)piperidine-4-carbonitrile;4-Phenyl-1-(4-tolylsulfonyl)-4-piperidinecarbonitrile;1-[(4-Methylphenyl)sulfonyl]-4-phenylpiperidine-4-carbonitrile;Einecs 246-283-6;1-[(4-Methylbenzene)sulfonyl]-4-phenylpiperidine-4-carbonitrile;4-Piperidinecarbonitrile, 1-[(4-Methylphenyl)sulfonyl]-4-phenyl-;4-Phenyl-1-(p-tolylsulfonyl)-piperidine-4-carbonitrile;1-(4-methylphenyl)sulfonyl-4-phenyl-isonipecotonitrile
• CAS NO: 24476-55-9
• Molecular Formula: C₁₉H₂₀N₂O₂S
• Molecular Weight: 340.4393
• EINECS: 246-283-6
• Mol File: 24476-55-9.mol
• Article Data: 4

Chemical Properties

• Melting Point: 200-201 °C
• Boiling Point: 533.8°C at 760 mmHg
• Flash Point: 276.6°C
• Appearance: /
• Density: 1.28g/cm³
• Vapor Pressure: 1.8E-11mmHg at 25°C
• Refractive Index: 1.63
• PKA: -6.70±0.40(Predicted)
• CAS DataBase Reference: 4-phenyl-1-(p-tolylsulphonyl)piperidine-4-carbonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: 4-phenyl-1-(p-tolylsulphonyl)piperidine-4-carbonitrile(24476-55-9)
• EPA Substance Registry System: 4-phenyl-1-(p-tolylsulphonyl)piperidine-4-carbonitrile(24476-55-9)

Safety Data

• Hazardous Substances Data: 24476-55-9(Hazardous Substances Data)

Usage

Description

4-phenyl-1-(p-tolylsulphonyl)piperidine-4-carbonitrile is a chemical compound with the molecular formula C21H20N2O2S. It is a piperidine derivative that features a phenyl group, a p-tolylsulphonyl group, and a carbonitrile group. 4-phenyl-1-(p-tolylsulphonyl)piperidine-4-carbonitrile is likely to have various potential applications in medicinal chemistry, particularly as a potential drug or intermediate in the synthesis of pharmaceuticals. The presence of the piperidine ring and the sulphonyl group suggests that it may exhibit biological activity, making it a compound of interest in the development of therapeutically useful compounds. Further research and study are required to fully understand the properties and potential uses of 4-phenyl-1-(p-tolylsulphonyl)piperidine-4-carbonitrile.

Uses

Used in Pharmaceutical Industry:
4-phenyl-1-(p-tolylsulphonyl)piperidine-4-carbonitrile is used as a potential drug candidate for the development of new therapeutic agents. Its unique structure, including the piperidine ring and sulphonyl group, may contribute to its biological activity and potential efficacy in treating various diseases.
Used in Medicinal Chemistry Research:
4-phenyl-1-(p-tolylsulphonyl)piperidine-4-carbonitrile serves as an intermediate in the synthesis of pharmaceuticals. Its chemical properties and reactivity can be exploited to create new compounds with potential therapeutic applications.
Used in Drug Discovery:
4-phenyl-1-(p-tolylsulphonyl)piperidine-4-carbonitrile is utilized in drug discovery processes to identify novel compounds with potential therapeutic effects. Its unique structural features may provide a starting point for the design and optimization of new drugs targeting specific biological pathways or receptors.
Used in Chemical Synthesis:
4-phenyl-1-(p-tolylsulphonyl)piperidine-4-carbonitrile can be employed as a building block in the synthesis of more complex organic molecules. Its versatile functional groups, such as the carbonitrile and sulphonyl groups, can be used in various chemical reactions to form new compounds with potential applications in different fields.

InChI:InChI=1/C19H20N2O2S/c1-16-7-9-18(10-8-16)24(22,23)21-13-11-19(15-20,12-14-21)17-5-3-2-4-6-17/h2-10H,11-14H2,1H3

Upstream product

• 42137-88-2 N,N-bis(2-chloroethyl)-p-toluenesulfonamide 
• 140-29-4 phenylacetonitrile 
• 7146-67-0 N-tosyldiethanolamine 
• 98-59-9 p-toluenesulfonyl chloride 
• 40481-13-8 4-phenyl-4-cyanopiperidine 

Downstream Products

• 22940-57-4 4-butyryl-4-phenyl-1-(toluene-4-sulfonyl)-piperidine 
• 1219922-35-6 4-fluorobenzyl-4-phenyl-1-(p-toluenesulfonyl)piperidine 
• 1219922-36-7 4-phenylacetyl-4-phenyl-1-(p-toluenesulfonyl)piperidine 
• 22940-59-6 4-benzoyl-4-phenyl-1-(p-toluenesulfonyl)piperidine 
• 95439-62-6 1-[1-(2-hydroxy-3-phenoxy-propyl)-4-phenyl-[4]piperidyl]-propan-1-one 
• 34798-79-3 4-phenyl-4-propionylpiperidine 
• 28018-10-2 N-Ethylnormeperidine 
• 132171-50-7 N-<(2-p-Aminophenyl-2-hydroxy)ethyl>-4-phenyl-4-carboethoxypiperidine 
• 807283-65-4 1-[2-(3-methoxy-phenyl)-2-oxo-ethyl]-4-phenyl-piperidine-4-carboxylic acid ethyl ester 
• 132171-53-0 N-<(2-o-Methoxyphenyl-2-hydroxy)ethyl>-4-phenyl-4-carboethoxypiperidine 
• 132171-55-2 N-<(2-o-Bromophenyl-2-hydroxy)ethyl>-4-phenyl-4-carboethoxypiperidine 
• 132171-57-4 N-<(2-o-Chlorophenyl-2-hydroxy)ethyl>-4-phenyl-4-carboethoxypiperidine 
• 132183-82-5 N-<(2-p-Methoxyphenyl-2-hydroxy)ethyl>-4-phenyl-4-carboethoxypiperidine 
• 132171-52-9 N-<(2-m-Methoxyphenyl-2-hydroxy)ethyl>-4-phenyl-4-carboethoxypiperidine 

Relevant articles and documents

MELANOCORTIN RECEPTOR ANTAGONIST COMPOUNDS, PROCESS FOR PREPARING THEM AND USE THEREOF IN HUMAN MEDICINE AND COSMETICS

The present invention relates to novel melanocortin receptor antagonist compounds corresponding to the general formula (I) below, to compositions containing them, to the process for preparing them and to their use in pharmaceutical or cosmetic compositions.

Synthesis and antinociceptive activity of ring substituted N-[(2-phenyl-2-hydroxy)ethyl]-4-phenyl-4-carboethoxypiperidines

A series of phenyl substituted N-[(2-phenyl-2-hydroxy)ethyl]-4-phenyl-4-carboethoxylpiperidine were synthesized and their antinociceptive activity tested in mice and compared with morphine sulphate. All compounds demonstrated antinociceptive activity in both the hot plate and the writhing tests. The studies showed that the antinociceptive activity is dependable on both the nature and the position of the substituent on the phenyl ring. Antagonism study with naloxone, suggests possible interaction of the new compounds with the opioid receptors.