24570-88-5

Basic information

• Product Name: 1-propyl-3-(p-tolylsulphonyl)urea
• Synonyms: 1-propyl-3-(p-tolylsulphonyl)urea;1-(p-Tolylsulfonyl)-3-propylurea;1-Tosyl-3-propylurea;4-Methyl-N-[(propylamino)carbonyl]benzenesulfonamide;N-(4-Methylphenylsulfonyl)-N'-propylurea;Einecs 246-322-7;1-propyl-3-(p-tolylsulfonyl)urea
• CAS NO: 24570-88-5
• Molecular Formula: C₁₁H₁₆N₂O₃S
• Molecular Weight: 256.32134
• EINECS: 246-322-7
• Mol File: 24570-88-5.mol
• Article Data: 5

Chemical Properties

• Melting Point: 151-152 °C
• Appearance: /
• Density: 1.21g/cm³
• Refractive Index: 1.537
• PKA: 5.26±0.10(Predicted)
• CAS DataBase Reference: 1-propyl-3-(p-tolylsulphonyl)urea(CAS DataBase Reference)
• NIST Chemistry Reference: 1-propyl-3-(p-tolylsulphonyl)urea(24570-88-5)
• EPA Substance Registry System: 1-propyl-3-(p-tolylsulphonyl)urea(24570-88-5)

Safety Data

• Hazardous Substances Data: 24570-88-5(Hazardous Substances Data)

Usage

Mechanism of action

Inhibits thyroperoxidase PTU works by inhibiting the enzyme thyroperoxidase, which is necessary for the production of thyroid hormone, thus preventing excessive hormone production.

Form and administration

Tablet form, taken orally PTU is available as a medication in tablet form and is typically taken orally by patients.

Precautions

Use under doctor's guidance, potential side effects and interactions It is important to use PTU under the guidance of a doctor, as it can have serious side effects and interactions with other medications.

InChI:InChI=1/C11H16N2O3S/c1-3-8-12-11(14)13-17(15,16)10-6-4-9(2)5-7-10/h4-7H,3,8H2,1-2H3,(H2,12,13,14)

Upstream product

• 51506-31-1 N-(allylcarbamoyl)-4-methylbenzenesulfonamide 
• 110-78-1 Propyl isocyanate 
• 70-55-3 toluene-4-sulfonamide 
• 623-95-0 1,3-dipropylurea 
• 18522-92-4 sodium p-toluenesulfonamide 
• 91181-34-9 1-allyl-3-tosylthiourea 
• 107-10-8 propylamine 
• 917-61-3 sodium isocyanate 
• 98-59-9 p-toluenesulfonyl chloride 
• 14549-38-3 phenyl N-(n-propyl)carbamate 

Downstream Products

• 1888-33-1 N-acetyl-(4-methylbenzene)sulfonamide 

Relevant articles and documents

A facile synthesis of sulfonylureas: Via water assisted preparation of carbamates

A novel and simple approach to the synthesis of sulfonylureas has been reported. It involved the reaction of various amines with diphenyl carbonate to yield the corresponding carbamates, which subsequently reacted with different sulphonamides to produce different sulfonylureas in excellent yields. The first reaction of diphenyl carbonate with amines was carried out in aqueous:organic (H2O:THF, 90:10) medium at room temperature to produce carbamates that paved a straightforward route to sulfonylureas after reaction with sulfonamides. The above process avoided traditional multistep protocols and the use of hazardous, irritant, toxic and moisture sensitive reagents such as phosgene, isocyanates and/or chloroformates.

Mechanosynthesis of pharmaceutically relevant sulfonyl-(thio)ureas

We demonstrate the first application of mechanochemistry to conduct the synthesis of sulfonyl-(thio)ureas, including known anti-diabetic drugs tolbutamide, chlorpropamide and glibenclamide, in good to excellent isolated yields by either stoichiometric base-assisted or copper-catalysed coupling of sulfonamides and iso(thio)cyanates. the Partner Organisations 2014.

KINETICS AND THERMODYNAMICS OF THE SYNTHESIS OF N-ALKYL-N'-TOLUENE-p-SULFONYLUREA

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