24615-84-7

Basic information

• Product Name: 2-CARBOXYETHYL ACRYLATE
• Synonyms: .beta.-Carboxyethylacrylate;2-carboxyethyl2-propenoate;2-Propenoicacid,2-carboxyethylester;beta-(acryloyloxy)propionicacid;beta-carboxyethylacrylate;hydracrylicacid,acrylate;sipomerb-cea;2-CARBOXYETHYL ACRYLATE
• CAS NO: 24615-84-7
• Molecular Formula: C₆H₈O₄
• Molecular Weight: 144.13
• EINECS: 246-359-9
• Product Categories: monomer;AcrylateCarbonyl Compounds;Acrylic Monomers;C6 to C7;Esters;Monomers;Acrylate
• Mol File: 24615-84-7.mol
• Article Data: 14

Chemical Properties

• Boiling Point: 103 °C19 mm Hg(lit.)
• Flash Point: >230 °F
• Appearance: /
• Density: 1.214 g/mL at 25 °C(lit.)
• Vapor Pressure: 0.00181mmHg at 25°C
• Refractive Index: n20/D 1.457(lit.)
• Storage Temp.: 2-8°C
• Solubility: H2O: soluble
• PKA: 3.95±0.10(Predicted)
• Merck: 13,132
• CAS DataBase Reference: 2-CARBOXYETHYL ACRYLATE(CAS DataBase Reference)
• NIST Chemistry Reference: 2-CARBOXYETHYL ACRYLATE(24615-84-7)
• EPA Substance Registry System: 2-CARBOXYETHYL ACRYLATE(24615-84-7)

Safety Data

• Hazard Codes: C,Xi
• Statements: 34-36/37/38
• Safety Statements: 23-26-36/37/39-45-36
• RIDADR: UN 3265 8/PG 2
• WGK Germany: 3
• RTECS: UD3325250
• Hazardous Substances Data: 24615-84-7(Hazardous Substances Data)

Usage

Chemical Properties

Colorless to light yellow viscid liquid

Uses

2-Carboxyethyl Acrylate is used in the preparation of DNase enzyme derivatives that act as potent preventative material of bacterial adhesion and biofilm formation in biomaterials.

Application

2-Carboxyethyl acrylate can be polymerized in solution or emulsion to produce acrylic, vinyl acrylic, or styrene acrylic polymers, which are distinguished by their low glass transition temperatures (<30°C) as homopolymers. Greater elasticity, as well as improved adhesion.

Preparation

Synthesis of 1-ethoxyethyl acrylate (EEA) and protected 2-carboxyethyl acrylate (proCEA)EEA and proCEA were synthesized following a previously published procedure and distilled prior to use. For the synthesis of proCEA (Figure 1), phosphoric acid (109 mg, 1.11 mmol) was weighed into a dry round bottom flask in a glovebox and then taken outside the glovebox, taking care that the phosphoric acid stayed dry. 2-Carboxyethyl acrylate (80 g, 555 mmol) and ethyl vinyl ether (48 g, 666 mmol) were added and the reaction was stirred for two days at room temperature. Hydrotalcite (Mg6Al2(OH)16CO3·4H2O, ~1 g) was added, stirred for one hour and filtered off. Excess ethyl vinyl ether was removed under reduced pressure and the product was distilled under reduced pressure (80 °C, 1.3 mbar).Figure 1 Synthesis of proCEA

Hazard

A severe skin irritant.

InChI:InChI=1/C6H8O4/c1-2-6(9)10-4-3-5(7)8/h2H,1,3-4H2,(H,7,8)

Upstream product

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Downstream Products

• 79-10-7 acrylic acid 
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• 67-56-1 methanol 
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Relevant articles and documents

Preparation of acrylic acid addition polymer and application of acidic catalyst in preparation of acrylic acid addition polymer

The invention relates to preparation of an acrylic acid addition polymer and application of an acidic catalyst in preparation of the acrylic acid addition polymer. According to the application of theacidic catalyst in preparation of the acrylic acid addition polymer, the acidic catalyst is one or more of protonic acid, Lewis acid and solid acid. The inventor of the invention finds that the acidiccatalyst of protonic acid, Lewis acid or solid acid can be used for catalyzing a Michael addition reaction of acrylic acid to prepare the acrylic acid addition polymer with good catalytic activity. In addition, the method for preparing the acrylic acid addition polymer through acrylic acid addition polymerization is simple in reaction process operation, convenient in process step control and highin addition polymerization yield.

RENEWABLE ACRYLIC ACID PRODUCTION AND PRODUCTS MADE THEREFROM

Processes and methods for making biobased acrylic acid products including acrylic acid, acrylic acid oligomers, acrylic acid esters, acrylic acid polymers and articles from renewable carbon resources are described herein.

Synthesis, determination of absolute configuration, and biological evaluation of spiro-fused thiadiazoline inhibitors of kinesin spindle protein (KSP)

A facile and highly convergent synthesis of biologically active spiro-fused thiadiazoline KSP inhibitors is reported. The highlights of the synthesis include the Michael reaction and cyclization of thiosemicarbazone to 1,3,4-thiadiazoline. This chemistry lends itself to the preparation of (+)-2, a potent and orally bioavailable anti-cancer agent, and to the development of a structure-activity relationship program.