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Cas Database

24922-02-9

24922-02-9

Identification

  • Product Name:Ethyl 3-cyclopropyl-3-oxopropanoate

  • CAS Number: 24922-02-9

  • EINECS:

  • Molecular Weight:156.181

  • Molecular Formula: C8H12O3

  • HS Code:2918300090

  • Mol File:24922-02-9.mol

Synonyms:Cyclopropanepropionicacid, b-oxo-, ethyl ester (8CI);Carbethoxymethyl cyclopropyl ketone;Ethyl beta-cyclopropyl-b-ketopropionate;

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Safety information and MSDS view more

  • Signal Word:Warning

  • Hazard Statement:H315 Causes skin irritationH319 Causes serious eye irritation H335 May cause respiratory irritation

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase
  • Manufacture/Brand:Usbiological
  • Product Description:Ethyl 3-cyclopropyl-3-oxopropanoate
  • Packaging:500mg
  • Price:$ 305
  • Delivery:In stock
  • Buy Now
  • Manufacture/Brand:TRC
  • Product Description:Ethyl3-cyclopropyl-3-oxopropanoate
  • Packaging:100g
  • Price:$ 100
  • Delivery:In stock
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:3-Cyclopropyl-3-oxo-propionic acid ethyl ester 95%
  • Packaging:5 g
  • Price:$ 16
  • Delivery:In stock
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:3-Cyclopropyl-3-oxo-propionic acid ethyl ester 95%
  • Packaging:25 g
  • Price:$ 42
  • Delivery:In stock
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  • Manufacture/Brand:SynQuest Laboratories
  • Product Description:3-Cyclopropyl-3-oxo-propionic acid ethyl ester 95%
  • Packaging:100 g
  • Price:$ 114
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Ethyl-3-cyclopropyl-3-oxopropionate 96%
  • Packaging:5g
  • Price:$ 406
  • Delivery:In stock
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  • Manufacture/Brand:Sigma-Aldrich
  • Product Description:Ethyl-3-cyclopropyl-3-oxopropionate 96%
  • Packaging:1g
  • Price:$ 105
  • Delivery:In stock
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:3-Cyclopropyl-3-oxo-propionic acid ethyl ester 97%
  • Packaging:5g
  • Price:$ 10
  • Delivery:In stock
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:3-Cyclopropyl-3-oxo-propionic acid ethyl ester 97%
  • Packaging:25g
  • Price:$ 33
  • Delivery:In stock
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  • Manufacture/Brand:Matrix Scientific
  • Product Description:3-Cyclopropyl-3-oxo-propionic acid ethyl ester 97%
  • Packaging:100g
  • Price:$ 94
  • Delivery:In stock
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Relevant articles and documentsAll total 2 Articles be found

Phenyl derivatives, their manufacture and use as pharmaceutical agents

-

Page/Page column 45-46, (2010/02/11)

This invention relates to compounds of the formula wherein one of R5, R6 and R7 is and X1, X2, Y1 to Y4, R1 to R13 and m and n are defined in the description, and to all enantiomers and pharmaceutically acceptable salts and/or esters thereof. The invention further relates to pharmaceutical compositions containing such compounds, to a process for their preparation and to their use for the treatment and/or prevention of diseases which are modulated by PPARδ and/or PPARα agonists.

PYRIDINE ANCHORS FOR HMG-COA REDUCTASE INHIBITORS

-

, (2008/06/13)

Compounds which are useful as inhibitors of cholesterol biosynthesis and thus as hypocholesterolemic agents are provided which have a quinoline or a pyridine anchor attached by means of a linker to a binding domain sidechain, which compounds inhibit the e

Process route upstream and downstream products

Process route

Cyclopropyl methyl ketone
765-43-5

Cyclopropyl methyl ketone

2-fluoroacetophenone
450-95-3

2-fluoroacetophenone

Ethyl 3-cyclopropyl-3-oxopropionate
24922-02-9

Ethyl 3-cyclopropyl-3-oxopropionate

Conditions
Conditions Yield
With NaH; SiO2; In hydrogenchloride; diethyl ether; ethanol; hexane; ethyl acetate; mineral oil; Diethyl carbonate;
55%
With NaH; SiO2; In hydrogenchloride; diethyl ether; ethanol; hexane; ethyl acetate; mineral oil; Diethyl carbonate;
55%
ethyl bromoacetate
105-36-2

ethyl bromoacetate

cyclopropropanecarbonitrile
5500-21-0

cyclopropropanecarbonitrile

ethyl acetoacetate
141-97-9

ethyl acetoacetate

3-amino-3-cyclopropyl-acrylic acid ethyl ester
77570-31-1,187827-14-1

3-amino-3-cyclopropyl-acrylic acid ethyl ester

Ethyl 3-cyclopropyl-3-oxopropionate
24922-02-9

Ethyl 3-cyclopropyl-3-oxopropionate

Conditions
Conditions Yield
ethyl bromoacetate; With zinc; In ethanol; for 0.333333h; Heating / reflux;
cyclopropropanecarbonitrile; In ethanol; for 1h; Heating / reflux;
With water; sodium hydrogencarbonate; In ethanol; at 0 ℃;
2,6-dichlorobenzohydroximoyl chloride
6579-27-7

2,6-dichlorobenzohydroximoyl chloride

Ethyl 3-cyclopropyl-3-oxopropionate
24922-02-9

Ethyl 3-cyclopropyl-3-oxopropionate

ethyl 5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazole-4-carboxylate
1020569-65-6

ethyl 5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazole-4-carboxylate

Conditions
Conditions Yield
With triethylamine; In dichloromethane; at 20 ℃; for 16h;
75%
With triethylamine; In tetrahydrofuran; at 20 ℃;
60%
With triethylamine; at 20 ℃;
57%
With triethylamine; at 20 ℃; for 24h;
56%
With triethylamine; at 20 ℃; for 16h;
118 g
at 20 ℃; for 24h;
22.37 g
With triethylamine; at 20 ℃; for 16h;
α-chloro-2,6-dichlorobenzaldoxime

α-chloro-2,6-dichlorobenzaldoxime

Ethyl 3-cyclopropyl-3-oxopropionate
24922-02-9

Ethyl 3-cyclopropyl-3-oxopropionate

ethyl 5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazole-4-carboxylate
1020569-65-6

ethyl 5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazole-4-carboxylate

Conditions
Conditions Yield
With triethylamine; In water; N,N-dimethyl-formamide; at 20 ℃; for 16h;
86%
2,6-Dichloro-N-hydroxybenzenecarboximidoyl chloride
6579-27-7

2,6-Dichloro-N-hydroxybenzenecarboximidoyl chloride

Ethyl 3-cyclopropyl-3-oxopropionate
24922-02-9

Ethyl 3-cyclopropyl-3-oxopropionate

ethyl 5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazole-4-carboxylate
1020569-65-6

ethyl 5-cyclopropyl-3-(2,6-dichlorophenyl)-1,2-oxazole-4-carboxylate

Conditions
Conditions Yield
Ethyl 3-cyclopropyl-3-oxopropionate; With triethylamine; at 25 ℃; for 5h;
2,6-Dichloro-N-hydroxybenzenecarboximidoyl chloride; at 25 ℃; for 12h;
59%
With triethylamine; at 20 ℃;
57%
o-Methoxybenzyl bromide
52289-93-7

o-Methoxybenzyl bromide

Ethyl 3-cyclopropyl-3-oxopropionate
24922-02-9

Ethyl 3-cyclopropyl-3-oxopropionate

ethyl 3-cyclopropyl-2-(2-methoxybenzyl)-3-oxopropanoate

ethyl 3-cyclopropyl-2-(2-methoxybenzyl)-3-oxopropanoate

Conditions
Conditions Yield
With N-ethyl-N,N-diisopropylamine; lithium chloride; In tetrahydrofuran; for 20h; Inert atmosphere; Reflux;
36%
o-Methoxybenzyl bromide
52289-93-7

o-Methoxybenzyl bromide

Ethyl 3-cyclopropyl-3-oxopropionate
24922-02-9

Ethyl 3-cyclopropyl-3-oxopropionate

2-amino-5-cyclopropyl-6-(2-methoxybenzyl)[1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-one

2-amino-5-cyclopropyl-6-(2-methoxybenzyl)[1,2,4]triazolo[1,5-a]pyrimidin-7(4H)-one

Conditions
Conditions Yield
Multi-step reaction with 2 steps
1: lithium chloride; N-ethyl-N,N-diisopropylamine / tetrahydrofuran / 20 h / Inert atmosphere; Reflux
2: 3-butyl-1-methyl-1H-imidazol-3-ium hexafluorophosphate / 1 h / 200 °C / Microwave irradiation
With N-ethyl-N,N-diisopropylamine; 3-butyl-1-methyl-1H-imidazol-3-ium hexafluorophosphate; lithium chloride; In tetrahydrofuran;
5-Amino-1,3-dimethylpyrazole
3524-32-1

5-Amino-1,3-dimethylpyrazole

Ethyl 3-cyclopropyl-3-oxopropionate
24922-02-9

Ethyl 3-cyclopropyl-3-oxopropionate

4-cyclopropyl-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridin-6-ol

4-cyclopropyl-1,3-dimethyl-1H-pyrazolo[3,4-b]pyridin-6-ol

Conditions
Conditions Yield
With acetic acid; at 130 ℃;
58%
Cyanothioacetamide
7357-70-2

Cyanothioacetamide

Ethyl 3-cyclopropyl-3-oxopropionate
24922-02-9

Ethyl 3-cyclopropyl-3-oxopropionate

4-cyclopropyl-2-mercapto-6-oxo-1,6-dihydropyridine-3-carbonitrile
854928-23-7

4-cyclopropyl-2-mercapto-6-oxo-1,6-dihydropyridine-3-carbonitrile

Conditions
Conditions Yield
With potassium tert-butylate; In N,N-dimethyl-formamide; at 20 - 80 ℃; for 4h; Inert atmosphere;
598.1 mg
anthranilic acid amide
28144-70-9,88-68-6

anthranilic acid amide

Ethyl 3-cyclopropyl-3-oxopropionate
24922-02-9

Ethyl 3-cyclopropyl-3-oxopropionate

2-cyclopropylquinazolin-4(3H)-one
459796-19-1

2-cyclopropylquinazolin-4(3H)-one

Conditions
Conditions Yield
With phosphoric acid; In ethanol; at 50 ℃; for 15h; Schlenk technique; Inert atmosphere;
95%
With ethanolamine-phosphoric acid functionalized polyacrylonitrile fibers (PANEAPF); In water; at 100 ℃; for 15h; Green chemistry;
95%

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