24935-08-8

Basic information

• Product Name: 1-(2-aminoethyl)pyrrolidin-2-one
• Synonyms: Einecs 246-539-7;1-(2-aminoethyl)pyrrolidin-2-one(SALTDATA: oxalate 0.3H2O);1-(2-AMinoethyl)-2-pyrrolidinone;2-Pyrrolidinone,1-(2-aMinoethyl)-;1-(2-AMinoethyl)-2-pyrrolidinone HCl;[2-(2-Oxopyrrolidin-1-yl)ethyl]amine;N-(2-Aminoethyl)pyrrolidin-2-one;N-(beta-Aminoethyl)-2-pyrrolidinone
• CAS NO: 24935-08-8
• Molecular Formula: C₆H₁₂N₂O
• Molecular Weight: 128.18
• EINECS: 246-539-7
• Mol File: 24935-08-8.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 125-130℃ (0.5 Torr)
• Flash Point: 118.3°C
• Appearance: /
• Density: 1.09g/cm³
• Vapor Pressure: 0.00624mmHg at 25°C
• Refractive Index: 1.507
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• PKA: 9.04±0.10(Predicted)
• CAS DataBase Reference: 1-(2-aminoethyl)pyrrolidin-2-one(CAS DataBase Reference)
• NIST Chemistry Reference: 1-(2-aminoethyl)pyrrolidin-2-one(24935-08-8)
• EPA Substance Registry System: 1-(2-aminoethyl)pyrrolidin-2-one(24935-08-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• HazardClass: IRRITANT
• Hazardous Substances Data: 24935-08-8(Hazardous Substances Data)

Usage

General Description

1-(2-aminoethyl)pyrrolidin-2-one, also known as AEP, is a chemical compound with the molecular formula C6H12N2O. It is a cyclic amino acid derivative with a pyrrolidinone ring structure, and a primary amine group linked to the second carbon atom of the pyrrolidinone ring. AEP is used in various applications, including as a monomer in the synthesis of polymers with potential application as drug delivery systems or biomaterials. It is also used in the production of surfactants and dispersants. Additionally, AEP has been investigated for its potential use in medical and pharmaceutical applications, such as in the development of novel drugs and as a building block for peptide and nucleic acid conjugates. Overall, AEP is a versatile chemical with a wide range of potential uses in various industries.

InChI:InChI=1/C6H12N2O/c7-3-5-8-4-1-2-6(8)9/h1-5,7H2

Upstream product

• 96-48-0 4-butanolide 
• 107-15-3 ethylenediamine 
• 88-12-0 1-ethenyl-2-pyrrolidinone 
• 57275-83-9 nitrile of 2-oxopyrrolidine-1-acetic acid 

Downstream Products

• 1117685-52-5 4-{[4-(2,6-dimethylpyridin-3-yl)oxypyridin-2-yl]amino}-N-[2-(2-oxopyrrolidin-1-yl)ethyl]benzamide 
• 7491-74-9 2-oxo-1-pyrrolidine acetamide 
• 1335131-99-1 1-[2-[8-(2-chlorophenyl)-2-methyl-6-(4-methylpiperazin-1-yl)purin-9-yl]ethyl]pyrrolidin-2-one hydrochloride 
• 1335132-17-6 1-[2-[6-chloro-8-(2-chlorophenyl)-2-methyl-purin-9-yl]ethyl]pyrrolidin-2-one 
• 1335196-98-9 C₂₃H₂₈ClN₇O 
• 117018-96-9 N-<β-(2-Pyrrolidon-1-yl)ethyl>-α-thiosulfoacetamidine 
• 95356-62-0 N-phenyl-N'-<β-(2-oxopyrrolidino)ethyl>thiourea 
• 95356-60-8 N-phenyl-N'-<β-(2-oxopyrrolidino)ethyl>urea 
• 92884-72-5 1-<2-(N-Benzoyl)aminoethyl>-2-oxopyrrolidine 

Relevant articles and documents

Direct Access to Primary Amines from Alkenes by Selective Metal-Free Hydroamination

Direct and selective synthesis of primary amines from easily available precursors is attractive yet challenging. Herein, we report the rapid synthesis of primary amines from alkenes via metal-free regioselective hydroamination at room temperature. Ammonium carbonate was used as ammonia surrogate for the first time, allowing for efficient conversion of terminal and internal alkenes into linear, α-branched, and α-tertiary primary amines under mild conditions. This method provides a straightforward and powerful approach to a wide spectrum of advanced, highly functionalized primary amines which are of particular interest in pharmaceutical chemistry and other areas.

SYNTHESIS AND BIOLOGICAL ACTIVITY OF SOME N-SUBSTITUTED 2-PYRROLIDONES

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