2497-91-8Relevant articles and documents
Benzoxazinone derivatives and their use as antibacterial agents
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Paragraph 0117-0120, (2018/09/12)
The invention discloses benzoxazinone derivatives, a synthesis method and applications thereof. The derivatives can be used as an antibacterial agent for treating infectious diseases caused by bacteria, especially tuberculosis (TB) caused by mycobacterium. Specifically, the invention relates to compounds represented by the formula (I), pharmaceutically acceptable salts thereof, and a pharmaceutical composition comprising the provided compounds; wherein the R1 to R4 are defined in the description. The invention aim to prepare novel compounds capable of inhibiting the mycobacterium activity, the compounds can be used as a potential novel drug for treating infectious diseases caused by bacteria, moreover, the compounds can be used to treat or prevent tuberculosis (TB) caused by mycobacterium, at the same time the problems related with drug resistance can be solved, and the drug metabolism property can be improved on the basis that the mycobacterium tuberculosis resistant activity is not influenced.
Anti-viral and anti-cancer agents
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, (2008/06/13)
2-chloro-5-nitrobenzoic acid and various other chloro and nitro substitute benzoic acid derivatives are disclosed for administration in tablet or injectable solution form for the prophylaxis and therapy of neoplasm or viral infection. The active compounds have surprising efficacy in various treatment regimes and have particular application to HIV-infection and demonstrate various beneficial effects, including regression of lesions in HIV-related Kaposi's sarcoma.
Synthesis of Polynitrodiazophenols
Atkins, Ronald L.,Wilson, William S.
, p. 2572 - 2578 (2007/10/02)
The formation of diazophenols by nitration of suitably substituted anilines and rearrangement of the nitroaromatic nitramines so formed is presented.The scope of the reaction is discussed, and a mechanism for the nitramine/diazophenol rearrangement is proposed which is consistent with 15N-labeling experiments.