25030-04-0

Basic information

• Product Name: 8-hydroxyadenosine 5'-monophosphate
• Synonyms: 8-hydroxyadenosine 5'-monophosphate
• CAS NO: 25030-04-0
• Molecular Formula: C₁₀H₁₄N₅O₈P
• Molecular Weight: 363.22
• Mol File: 25030-04-0.mol

Chemical Properties

• Appearance: /
• CAS DataBase Reference: 8-hydroxyadenosine 5'-monophosphate(CAS DataBase Reference)
• NIST Chemistry Reference: 8-hydroxyadenosine 5'-monophosphate(25030-04-0)
• EPA Substance Registry System: 8-hydroxyadenosine 5'-monophosphate(25030-04-0)

Safety Data

• Hazardous Substances Data: 25030-04-0(Hazardous Substances Data)

Upstream product

• 61-19-8 5'-adenosine monophosphate 
• 103022-80-6 adenylyl-(2'-5')-adenylyl-(2'-5')-8-hydroxyadenosine 
• 23567-96-6 8-bromoadenosine-5'-monophosphate 
• 2946-39-6 8-bromoadenosine 

Relevant articles and documents

Hydroxylating Activity of a Water-soluble Manganese Porphyrin Associated with Potassium Hydrogen Persulfate: Formation of 8-hydroxyadenosine-5'-mono-phosphate from AMP.

The associacion of potassium monopersulfate, KHSO5, with a wather-soluble manganese porphyrin complex has been recently reported as being a very efficient system for the oxidative cleavage of DNA (Fouquet et al., J.Chem.Soc., Chem.Commun., 1987, 1169); similar results are observed with RNA.As puzzle piece of the mechanism of this oxidative degradation of nucleic acids, we report in the present communications the identification of 8-hydroxyadenosine-5'-monophosphate as oxidation product of adenosine-5'-monophosphate (AMP) by KHSO5/(OAc)5.In the absense of manganese catalyst, the only detectable compound is the adenosine-N1-5'-monophosphate.

Synthesis of cyclic adenosine 5′-diphosphate ribose analogues: A C2′ endo/syn "southern" ribose conformation underlies activity at the sea urchin cADPR receptor

Novel 8-substituted base and sugar-modified analogues of the Ca 2+ mobilizing second messenger cyclic adenosine 5′-diphosphate ribose (cADPR) were synthesized using a chemoenzymatic approach and evaluated for activity in sea urchin egg homogenate (SUH) and in Jurkat T-lymphocytes; conformational analysis investigated by 1H NMR spectroscopy revealed that a C2′ endo/syn conformation of the "southern" ribose is crucial for agonist or antagonist activity at the SUH-, but not at the T cell-cADPR receptor.

Synthesis and properties of 2',5'-adenylate trimers bearing 2'-terminal 8-bromo or 8-hydroxyadenosine

Trimers of 2',5'-oligoadenylic acids bearing 2'-terminal 8-bromo- or 8-hydroxyadenosine have been synthesized by the phosphotriester method.Some properties of these compounds were studied by circular dichroism (CD) spectroscopy.The 2',5'-adenylate trimer, A2'p5'A2'p5'HOA (10a) was found to have less stacked structure than the 2',5'-adenylate trimers A2'p5'A2'p5'BrA (11) and A2'p5'A2'p5'A (10b).Keywords - modified 2',5'-adenylate trimer; N6,N6,3'-O-tribenzoyladenosine; 8-bromoadenosine; coupling agent; CD spectrum; HPLC; reversed-phase liquid chromatography.