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2525-16-8

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2525-16-8 Usage

Chemical Properties

Colorless liquid

Synthesis Reference(s)

Organic Syntheses, Coll. Vol. 4, p. 588, 1963Tetrahedron Letters, 20, p. 4671, 1979 DOI: 10.1016/S0040-4039(01)86679-X

Check Digit Verification of cas no

The CAS Registry Mumber 2525-16-8 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,5,2 and 5 respectively; the second part has 2 digits, 1 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 2525-16:
(6*2)+(5*5)+(4*2)+(3*5)+(2*1)+(1*6)=68
68 % 10 = 8
So 2525-16-8 is a valid CAS Registry Number.
InChI:InChI=1/C7H13NO/c1-9-7-5-3-2-4-6-8-7/h2-6H2,1H3

2525-16-8 Well-known Company Product Price

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  • Aldrich

  • (A95804)  1-Aza-2-methoxy-1-cycloheptene  99%

  • 2525-16-8

  • A95804-5G

  • 872.82CNY

  • Detail
  • Aldrich

  • (A95804)  1-Aza-2-methoxy-1-cycloheptene  99%

  • 2525-16-8

  • A95804-25G

  • 3,011.58CNY

  • Detail

2525-16-8SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 13, 2017

Revision Date: Aug 13, 2017

1.Identification

1.1 GHS Product identifier

Product name 7-METHOXY-3,4,5,6-TETRAHYDRO-2H-AZEPINE

1.2 Other means of identification

Product number -
Other names 2H-Azepine,3,4,5,6-tetrahydro-7-methoxy

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:2525-16-8 SDS

2525-16-8Relevant articles and documents

Synthesis and bronchodilatory activity of some nitrogen bridgehead compounds

Jindal, Dharam Paul,Bhatti, Ravinder Singh,Ahlawat, Seema,Gupta, Ranju

, p. 419 - 425 (2002)

A series of tricyclic nitrogen bridgehead compounds 7-22 have been synthesised and evaluated for their in vitro bronchodilatory activity using isolated guinea pig tracheal chain, precontracted with acetylcholine. The relaxant effect of 2,3,4,5-tetrahydroazepino[2,1-b]-8,9-dimethoxyquinazolin-11(1H)-one (7) (DPJ-386) was greater than that of theophylline, aminophylline and quinazoline derivative 3, which lacks methoxy groups at positions 8 and 9. Various nitrogen containing functionalities such as benzylamino, acetamido, benzamido and phthalimido were also introduced at 9 position of 3. This resulted in loss of relaxation activity in precontracted guinea pig tracheal chain. These results show that the better relaxation property possessed by compound 7 hydrochloride is due to methoxy groups at 8 and 9 positions.

Pyrrolopyrimidine Derivatives as Novel Inhibitors of Multidrug Resistance-Associated Protein 1 (MRP1, ABCC1)

Schmitt, Sven Marcel,Stefan, Katja,Wiese, Michael

, p. 3018 - 3033 (2016/05/19)

Five series of pyrrolo[3,2-d]pyrimidines were synthesized and evaluated with respect to potency and selectivity toward multidrug resistance-associated protein 1 (MRP1, ABCC1). This transport protein is a major target to overcome multidrug resistance in cancer patients. We investigated differently substituted pyrrolopyrimidines using the doxorubicin selected and MRP1 overexpressing small cell lung cancer cell line H69 AR in a calcein AM and daunorubicin cell accumulation assay. New compounds with high potency and selectivity were identified. Piperazine residues at position 4 bearing large phenylalkyl side chains proved to be beneficial for MRP1 inhibition. Its replacement by an amino group led to decreased activity. Aliphatic and aliphatic-aromatic variations at position 5 and 6 revealed compounds with IC50 values in high nanomolar range. All investigated compounds had low affinity toward P-glycoprotein (P-gp, ABCB1). Pyrrolopyrimidines with small substituents showed moderate inhibition against breast cancer resistance protein (BCRP, ABCG2).

Targeting the polyamine transport system with benzazepine- and azepine-polyamine conjugates

Tomasi, Sophie,Renault, Jacques,Martin, Bénédicte,Duhieu, Stephane,Cerec, Virginie,Le Roch, Myriam,Uriac, Philippe,Delcros, Jean-Guy

experimental part, p. 7647 - 7663 (2011/02/22)

The polyamine transport system (PTS) whose activity is up-regulated in cancer cells is an attractive target for drug design. Two heterocyclic (azepine and benzazepine) systems were conjugated to various polyamine moieties through an amidine bound to afford 18 compounds which were evaluated for their affinity for the PTS and their ability to use the PTS for cell delivery. Structure-activity relationship studies and lead optimization afforded two attractive PTS targeting compounds. The azepine-spermidine conjugate 14 is a very selective substrate of the PTS that may serve as a vector for radioelements used for diagnoses or therapeutics in nuclear medicine. The nitrobenzazepine-spermine conjugate 28 is a very powerful PTS inhibitor with very low intrinsic cytotoxicity, able to prevent the growth of polyamine depleted cells in presence of exogenous polyamines.

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