252881-74-6

Basic information

• Product Name: TERT-BUTYL 12-AMINO-4 7 10-TRIOXA-DODECA
• Synonyms: TERT-BUTYL 12-AMINO-4 7 10-TRIOXA-DODECA;H2N-PEG3-tBu;H2N-PEG3-CH2CH2COOtBu;tert-Butyl 12-aMino-4,7,10-trioxa-dodec;tert-butyl 3-{2-[2-(2-hydroxyethoxy)ethoxy]ethoxy}propanoate;3-[2-[2-(2-Aminoethoxy)ethoxy]ethoxy]propionic acid tert-butyl ester;Propanoic acid,3-[2-[2-(2-aMinoethoxy)ethoxy]ethoxy]-, 1,1-diMethylethyl ester;tert-Butyl 12-amino-4,7,10-trioxadodecanoate technical, >=80% (T)
• CAS NO: 252881-74-6
• Molecular Formula: C₁₃H₂₇NO₅
• Molecular Weight: 277.358
• Product Categories: PEG-COOtBu
• Mol File: 252881-74-6.mol
• Article Data: 21

Chemical Properties

• Boiling Point: 365.8°C at 760 mmHg
• Flash Point: 169.7 °C
• Appearance: /
• Density: 1.057g/cm³
• Vapor Pressure: 7.78E-07mmHg at 25°C
• Refractive Index: 1.45
• Storage Temp.: −20°C
• PKA: 8.74±0.10(Predicted)
• CAS DataBase Reference: TERT-BUTYL 12-AMINO-4 7 10-TRIOXA-DODECA(CAS DataBase Reference)
• NIST Chemistry Reference: TERT-BUTYL 12-AMINO-4 7 10-TRIOXA-DODECA(252881-74-6)
• EPA Substance Registry System: TERT-BUTYL 12-AMINO-4 7 10-TRIOXA-DODECA(252881-74-6)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38
• Safety Statements: 26
• WGK Germany: 3
• F: 10-34
• Hazardous Substances Data: 252881-74-6(Hazardous Substances Data)

Usage

Description

Amino-PEG3-t-butyl ester is a PEG linker containing an amino group with a t-butyl protected carboxyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The amino group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc. The t-butyl protected carboxyl group can be deprotected under acidic conditions.

Uses

tert-Butyl 12-amino-4,7,10-trioxadodecanoate is generally used as a spacer or linker in bioconjugate chemistry. Some of its applications are:Synthesis of the tetanus-toxin conjugate of MUC1 glycopeptide antigen, as a potential antitumor vaccine.Synthesis of self-assembled monolayer-based surface-enhanced raman scattering (SERS) labels for immuno-SERS microscopy.Synthesis of polycationic adamantane-based dendrons for cell imaging.Synthesis of phthalocyanine (Pc)-peptide conjugates as potential fluorescence imaging agents for cancers overexpressing epidermal growth factor receptors (EGFR).

InChI:InChI=1/C13H26O6/c1-13(2,3)19-12(15)4-6-16-8-10-18-11-9-17-7-5-14/h14H,4-11H2,1-3H3

Upstream product

• 1349193-22-1 8-dibenzylamino-3,6-dioxaoctan-1-ol 
• 1663-39-4 tert-Butyl acrylate 
• 252881-73-5 tert-Butyl 3-(2-(2-(2-azidoethoxyl)ethoxy)ethoxy)propanoate 
• 217817-01-1 tert-butyl 3-[2-[2-[2-(4-methylphenyl)sulfonyloxyethoxy]ethoxy]ethoxy]propanoate 
• 1024602-74-1 tert-butyl 3-(2-{2-[2-(methanesulphonyloxy)ethoxy]ethoxy}ethoxy)propanoate 
• 112-27-6 2,2'-[1,2-ethanediylbis(oxy)]bisethanol 
• 186020-66-6 3-{2-[2-(2-hydroxy-ethoxy)-ethoxy]-ethoxy}-propionic acid tert-butyl ester 

Downstream Products

• 867062-95-1 12-{N-[(9H-fluoren-9-yl)methoxycarbonyl]amido}-4,7,10-trioxadodecanoic acid 
• 784105-33-5 3-{2-[2-(2-aminoethoxy)ethoxy]ethoxy}propanoic acid 
• 1325213-00-0 RF-Lys(OEG-Cbz)-O-octyl 
• 1325213-18-0 tert-butyl 3-oxo-1-phenyl-2,7,10,13-tetraoxa-4-azahexadecan-16-oate 
• 1310327-54-8 1-((R)-9-amino-4-(2,2-diphenylacetamido)-1-(4-hydroxyphenyl)-3,11-dioxo-14,17,20-trioxa-2,8 ,10-triazadocos-9-en-22-yl)-4-((E)-2-(1,2,3,5,6,7-hexahydropyrido[3,2,1-ij]quinolin-9-yl)ethenyl)-2,6-dimethylpyridinium hydrotrifluoroacetate trifluoroacetate 
• 1310327-18-4 3-oxo-1-phenyl-2,7,10,13-tetraoxa-4-azahexadecan-16-oic acid 
• 782475-30-3 3-{2-[2-(2-{4-[4-(3,5-Dioxo-hexyl)-phenylcarbamoyl]-butyrylamino}-ethoxy)-ethoxy]-ethoxy}-propionic acid tert-butyl ester 

Relevant articles and documents

CONJUGATES OF A CELL-BINDING MOLECULE WITH CAMPTOTHECIN ANALOGS

Provided are conjugates of camptothecin analogs with a cell-binding molecule of formula (I), wherein R1, R2, R3, R4, R5, X, L, n, m, T and ----- are defined herein. It also provides methods of making the conjugates of camptothecin analogs to a cell-binding agent, as well as methods of using the conjugates in targeted treatment of cancer, infection, and immunological disorders.

CONJUGATION LINKERS CONTAINING 2,3-DIAMINOSUCCINYL GROUP

Provided is a conjugate of a cytotoxic drug/molecule to a cell-binding molecule with a bis-linker (adual-linker) containing a 2, 3-diaminosuccinyl group. It also relates to preparation of the conjugate of a cytotoxic drug/molecule to a cell-binding molecule with the bis-linker, particularly when the drug having functional groups of amino, hydroxyl, diamino, amino-hydroxyl, dihydroxyl, carboxyl, hydrazine, aldehyde and thiol for conjugation with the bis-linker in a specific manner, as well as the therapeutic use of the conjugates.

A CONJUGATE OF A CYTOTOXIC AGENT TO A CELL BINDING MOLECULE WITH BRANCHED LINKERS

Provided is a conjugation of cytotoxic drug to a cell-binding molecule with a side-chain linker. It provides side-chain linkage methods of making a conjugate of a cytotoxic molecule to a cell-binding ligand, as well as methods of using the conjugate in targeted treatment of cancer, infection and immunological disorders.