256424-63-2

Basic information

• Product Name: (-)-(E)-[(4R)-4-(2,4-dichlorophenyl)-1,3-dithiolane-2-ylidene]-1H-imidazol-1-acetonitrile
• Synonyms: (-)-(E)-[(4R)-4-(2,4-dichlorophenyl)-1,3-dithiolane-2-ylidene]-1H-imidazol-1-acetonitrile
• CAS NO: 256424-63-2
• Molecular Weight: 354.284
• Mol File: 256424-63-2.mol
• Article Data: 3

Chemical Properties

• Melting Point: 143-146oC
• Boiling Point: 499.1±55.0 °C(Predicted)
• Density: 1.52±0.1 g/cm3(Predicted)
• CAS DataBase Reference: (-)-(E)-[(4R)-4-(2,4-dichlorophenyl)-1,3-dithiolane-2-ylidene]-1H-imidazol-1-acetonitrile(CAS DataBase Reference)
• NIST Chemistry Reference: (-)-(E)-[(4R)-4-(2,4-dichlorophenyl)-1,3-dithiolane-2-ylidene]-1H-imidazol-1-acetonitrile(256424-63-2)
• EPA Substance Registry System: (-)-(E)-[(4R)-4-(2,4-dichlorophenyl)-1,3-dithiolane-2-ylidene]-1H-imidazol-1-acetonitrile(256424-63-2)

Safety Data

• Hazardous Substances Data: 256424-63-2(Hazardous Substances Data)

Usage

Uses

(S)-Luliconazole is the (S)--enantiomer of Luliconazole, an azole antifungal drug. Luliconazole was found to interfere with ergosterol biosynthesis in cell-free extracts of Candida albican, while no interference due to (S)-Luliconazole was found.

Upstream product

• 187164-19-8 luliconazole 
• 541-73-1 1,3-Dichlorobenzene 
• 4252-78-2 2,2',4'-trichloroacetophenone 
• 23184-45-4 2-cyanomethyl-imidazole 
• 229334-55-8 (S)-2-chloro-1-(2,4-dichlorophenyl)ethyl methanesulfonate 

Relevant articles and documents

Imidazole acetonitrile derivative acid salt as well as preparation method and application thereof

The invention relates to an imidazole acetonitrile derivative acid salt as well as a preparation method and an application thereof, belongs to the technical field of drug synthesis, and aims to solve the problem about how to improve stability and increase the yield. The method comprises steps as follows: an imidazole acetonitrile derivative is dissolved in a water-insoluble polar organic solvent, then corresponding acid is added for a salt forming reaction, and the acid salt of the product imidazole acetonitrile derivative is gradually separated out, and applied to preparation of Luliconazole. The acid salt itself has better stability and used as an intermediate for preparing Luliconazole at the same time, the problem of mutual inversion of Z-E configuration in the Luliconazole preparation process can be solved, the Z configuration can be inverted into the E configuration, the configuration inversion stability is guaranteed, and the yield is higher. The effects of simple technology and easiness in operation are also realized.

EXTERNAL PHARMACEUTICAL COMPOSITION

A pharmaceutical composition for external use, including: i) luliconazole represented by the following structural formula (1) and/or a salt thereof; and ii) one or two or more selected from N-methyl-2-pyrrolidone, propylene carbonate, and crotamiton.