2574-03-0

Basic information

• Product Name: [(4-nitrophenyl)methylidyne]azane oxide
• CAS NO: 2574-03-0
• Molecular Formula: C₇H₄N₂O₃
• Molecular Weight: 164.1183
• Mol File: 2574-03-0.mol
• Article Data: 26

Chemical Properties

• Density: 1.32g/cm³
• Refractive Index: 1.589
• CAS DataBase Reference: [(4-nitrophenyl)methylidyne]azane oxide(CAS DataBase Reference)
• NIST Chemistry Reference: [(4-nitrophenyl)methylidyne]azane oxide(2574-03-0)
• EPA Substance Registry System: [(4-nitrophenyl)methylidyne]azane oxide(2574-03-0)

Safety Data

• Hazardous Substances Data: 2574-03-0(Hazardous Substances Data)

Upstream product

• 1129-37-9 4-nitrobenzaldehyde oxime 
• 58402-81-6 (Z)-4-nitrobenzohydroximoyl chloride 
• 122-04-3 4-nitro-benzoyl chloride 
• 555-16-8 4-nitrobenzaldehdye 
• 1011-84-3 4-nitrobenzohydroximoyl chloride 

Downstream Products

• 110-00-9 furan 
• 4282-33-1 dimethyl 3,4-furandicarboxylate 
• 4264-05-5 3-(p-nitrophenyl)isoxazole 
• 53890-65-6 3-(4-nitro-phenyl)-isoxazole-4,5-dicarboxylic acid dimethyl ester 
• 31562-30-8 3,4-di(4-nitrophenyl)-1,2,5-oxadiazole N-oxide 
• 134935-83-4 3-(4-nitrophenyl)-5-phenyl-4-nitro-Δ²-isoxazoline 
• 134935-84-5 3-(4-nitrophenyl)-4-phenyl-5-nitro-Δ²-isoxazoline 
• 38708-02-0 5-(1,1-dinitro-ethyl)-3-(4-nitro-phenyl)-4,5-dihydro-isoxazole 
• 99343-42-7 C₉H₆⁽²⁾H₂N₂O₃ 
• 53931-34-3 (O-isopropylidene-1',2'-O-methyl-3'-α-D-xylo-furannosyl-4')-5-p-nitrophenyl-3-oxazole-1,2 
• 542-92-7 cyclopenta-1,3-diene 
• 55949-76-3 Cyclopenta-2,5-diene-1,2-dicarboxylic acid dimethyl ester 
• 125379-62-6 5-(Methylphenylamino)-3-(4-nitrophenyl)isoxazol 
• 144835-88-1 (3aR,6aS)-5-(3,5-Dichloro-phenyl)-3-(4-nitro-phenyl)-3a,6a-dihydro-pyrrolo[3,4-d]isoxazole-4,6-dione 

Relevant articles and documents

Dibenzazepine-linked isoxazoles: New and potent class of α-glucosidase inhibitors

α-Glucosidase inhibition is a valid approach for controlling hyperglycemia in diabetes. In the current study, new molecules as a hybrid of isoxazole and dibenzazepine scaffolds were designed, based on their literature as antidiabetic agents. For this, a series of dibenzazepine-linked isoxazoles (33–54) was prepared using Nitrile oxide-Alkyne cycloaddition (NOAC) reaction, and evaluated for their α-glucosidase inhibitory activities to explore new hits for treatment of diabetes. Most of the compounds showed potent inhibitory potency against α-glucosidase (EC 3.2.1.20) enzyme (IC50 = 35.62 ± 1.48 to 333.30 ± 1.67 μM) using acarbose as a reference drug (IC50 = 875.75 ± 2.08 μM). Structure-activity relationship, kinetics and molecular docking studies of active isoxazoles were also determined to study enzyme-inhibitor interactions. Compounds 33, 40, 41, 46, 48–50, and 54 showed binding interactions with critical amino acid residues of α-glucosidase enzyme, such as Lys156, Ser157, Asp242, and Gln353.

One-pot Synthesis of Some Novel Xanthine Derived Isoxazoles as Potent Antibacterial Agents

In search of better antibacterial agents, a series of novel xanthine derived 3,5-disubstituted isoxazole derivatives were synthesized (3a-3j) in one-pot using 8-chloro-1,3-dimethyl-7-(prop-2-yn-1-yl)-1H-purine-2,6(3H,7H)-dione and aromatic aldehydes and f

1,3-Dipolar cycloaddition reactions of acyl phosphonates with nitrile oxides: synthesis of phosphonate-containing dioxazole derivatives

New phosphonate-containing five-membered heterocyclic dioxazole derivatives are synthesized via 1,3-dipolar cycloaddition reactions of nitrile oxides used as dipole with acyl phosphonates under basic conditions. Herein, acyl phosphonates take part in the