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Cas Database

25964-44-7

25964-44-7

Identification

  • Product Name:1(2H)-Naphthalenone,3,4-dihydro-2-[[(4-methylphenyl)sulfonyl]methyl]-

  • CAS Number: 25964-44-7

  • EINECS:

  • Molecular Weight:314.3987

  • Molecular Formula: C18H18 O3 S

  • HS Code:

  • Mol File:25964-44-7.mol

Synonyms:1(2H)-Naphthalenone,3,4-dihydro-2-[(p-tolylsulfonyl)methyl]- (8CI); 3,4-Dihydro-2-[(p-tolylsulfonyl)methyl]-1(2H)-naphthalenone;NSC 280876

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Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

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Relevant articles and documentsAll total 2 Articles be found

Selectfluor-Mediated Synthesis of β-Acyl Allyl Sulfones/β-Acyl Allyl Benzotriazoles from Ketones/Acetylenes, Aryl Sulfinates/Benzotriazole, and DMSO as a Dual-Carbon Synthon

Kalari, Saradhi,Karale, Uttam B.,Rode, Haridas B.

, (2022/02/07)

A Selectfluor-mediated approach for the synthesis of β-acyl allyl sulfones/β-acyl allyl benzotriazoles with excellent atom economy from readily available acetophenones/aryl acetylenes, aryl sulfinates/benzotriazoles, and dimethyl sulfoxide (DMSO) is described. In this protocol, DMSO acts as a dual-carbon synthon, resulting in a transition-metal-free construction of two C-C and one C-S or two C-C and one C-N bonds in one pot. This approach is extended to generate chemically diverse compounds. Additionally, β-acyl allyl sulfones/β-acyl allyl benzotriazoles were prepared from acetylenes instead of acetophenones.

Reductive radical-initiated 1,2-C migration assisted by an azidyl group

Song, Jin-Na,Wang, Zikun,Zhang, Xueying,Zhang, Zhansong

, p. 7921 - 7926 (2020/08/19)

We report here a novel reductive radical-polar crossover reaction that is a reductive radical-initiated 1,2-C migration of 2-azido allyl alcohols enabled by an azidyl group. The reaction tolerates diverse migrating groups, such as alkyl, alkenyl, and aryl groups, allowing access to n+1 ring expansion of small to large rings. The possibility of directly using propargyl alcohols in one-pot is also described. Mechanistic studies indicated that an azidyl group is a good leaving group and provides a driving force for the 1,2-C migration. This journal is

Process route upstream and downstream products

Process route

C<sub>11</sub>H<sub>11</sub>N<sub>3</sub>O

C11H11N3O

sodium 4-methylbenzenesulfinate
824-79-3

sodium 4-methylbenzenesulfinate

NSC<sub>280876</sub>
25964-44-7

NSC280876

Conditions
Conditions Yield
With trimethylsilylazide; In water; dimethyl sulfoxide; at 50 ℃; for 48h;
64%
dimethyl sulfoxide
67-68-5,8070-53-9

dimethyl sulfoxide

sodium 4-methylbenzenesulfinate
824-79-3

sodium 4-methylbenzenesulfinate

3,4-dihydronaphthalene-1(2H)-one
529-34-0

3,4-dihydronaphthalene-1(2H)-one

NSC<sub>280876</sub>
25964-44-7

NSC280876

Conditions
Conditions Yield
With Selectfluor; at 110 ℃; for 12h; Sealed tube;
72%

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