25964-44-7

Basic information

• Product Name: 2-{[(4-methylphenyl)sulfonyl]methyl}-3,4-dihydronaphthalen-1(2H)-one
• CAS NO: 25964-44-7
• Molecular Formula: C₁₈H₁₈O₃S
• Molecular Weight: 314.3987
• Mol File: 25964-44-7.mol
• Article Data: 2

Chemical Properties

• Boiling Point: 524.2°C at 760 mmHg
• Flash Point: 335°C
• Density: 1.226g/cm³
• Vapor Pressure: 4.39E-11mmHg at 25°C
• Refractive Index: 1.586
• CAS DataBase Reference: 2-{[(4-methylphenyl)sulfonyl]methyl}-3,4-dihydronaphthalen-1(2H)-one(CAS DataBase Reference)
• NIST Chemistry Reference: 2-{[(4-methylphenyl)sulfonyl]methyl}-3,4-dihydronaphthalen-1(2H)-one(25964-44-7)
• EPA Substance Registry System: 2-{[(4-methylphenyl)sulfonyl]methyl}-3,4-dihydronaphthalen-1(2H)-one(25964-44-7)

Safety Data

• Hazardous Substances Data: 25964-44-7(Hazardous Substances Data)

Usage

Physical properties

white to off-white crystalline powder

Use

research and development as a potential drug candidate

Potential applications

pharmaceutical industry for the treatment of various diseases and conditions

Functional groups

sulfonyl and naphthalenone

Role in biological activity

may play a role in biological activity and pharmacological properties

Need for further research

further research is needed to fully understand the potential uses and effects of this compound.

Upstream product

• 67-68-5 dimethyl sulfoxide 
• 824-79-3 sodium 4-methylbenzenesulfinate 
• 529-34-0 3,4-dihydronaphthalene-1(2H)-one 

Relevant articles and documents

Selectfluor-Mediated Synthesis of β-Acyl Allyl Sulfones/β-Acyl Allyl Benzotriazoles from Ketones/Acetylenes, Aryl Sulfinates/Benzotriazole, and DMSO as a Dual-Carbon Synthon

A Selectfluor-mediated approach for the synthesis of β-acyl allyl sulfones/β-acyl allyl benzotriazoles with excellent atom economy from readily available acetophenones/aryl acetylenes, aryl sulfinates/benzotriazoles, and dimethyl sulfoxide (DMSO) is described. In this protocol, DMSO acts as a dual-carbon synthon, resulting in a transition-metal-free construction of two C-C and one C-S or two C-C and one C-N bonds in one pot. This approach is extended to generate chemically diverse compounds. Additionally, β-acyl allyl sulfones/β-acyl allyl benzotriazoles were prepared from acetylenes instead of acetophenones.