259655-05-5Relevant articles and documents
Elimination reactions of N-alkyl-N-chlorothenylamines promoted by MeONa-MeOH and Et2NH-MeCN. Effect of the β-aryl group on the imine-forming transition state
Pyun, Sang Yong,Lee, Dong Choon,Seung, Yoon Je,Cho, Bong Rae
, p. 5327 - 5330 (2005)
Elimination reactions of N-alkyl-N-chlorothenylamines 1-4 with MeONa-MeOH and Et2NH-MeCN have been studied kinetically. The elimination reactions are regiospecific, producing only the conjugated imines. The reactions are second order and exhibit substantial values of Hammett ρ and k H/kD, and an E2 mechanism is evident. The relative rates of elimination for Me/Et/i-Pr/i-Bu substituents are 1/0.5/0.2/0.02 with MeONa-MeOH and 1/0.4/0.2/0.06 with Et2NH-MeCN. The transition state structure changes toward more product-like as the base is changed from MeONa-MeOH to Et2NH-MeCN. Comparison with existing data reveals that the structure of the transition state is relatively insensitive to the β-aryl group variation.
General and environmentally friendly synthesis of heterocyclic multidentate molecules based on microwave-assisted heating protocol
Regnier, Thomas,Lavastre, Olivier
, p. 155 - 159 (2007/10/03)
An efficient microwave heating methodology for the synthesis of heterocyclic multidentate molecules is reported. Each compound was obtained with high yield and purity in a few minutes from easily available starting materials such as amines, heteroaldehydes and N-hydroxymethyl pyrazoles or triazoles. In addition, this approach allows synthesis without any solvent or organic and inorganic by-products.
