260353-67-1Relevant articles and documents
6-fluorobicyclo[3.1.0]hexane derivatives
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, (2008/06/13)
The present invention provides fluorobicyclo[3.1.0]hexane derivatives represented by the formula [wherein R1and R2are the same or different and each represents a hydrogen atom, a C1-10alkyl group, a C3-8cycloalk
Synthesis, SARs, and pharmacological characterization of 2-Amino-3 or 6-fluorobicyclo[3.1.0]hexane-2,6-dicarboxylic acid derivatives as potent, selective, and orally active group II metabotropic glutamate receptor agonists
Nakazato,Kumagai,Sakagami,Yoshikawa,Suzuki,Chaki,Ito,Taguchi,Nakanishi,Okuyama
, p. 4893 - 4909 (2007/10/03)
(+)-2-Aminobicyclo[3.1.0]hexane-2,6-dicarboxylic acid (4, LY354740), a highly selective and orally active group II metabotropic glutamate receptor (mGluR) agonist, has increased interest in the study of group II mGluRs. Our interest focused on a conformat