2645-36-5

Basic information

• Product Name: 1-Piperidinecarboxamide,N-phenyl-
• Synonyms: 1-Piperidinecarboxanilide(7CI,8CI); 1,1-Pentamethyleneurea, 3-phenyl-; 1-(N-Phenylcarbamoyl)piperidine;1-(Phenylaminocarbonyl)piperidine; N,N-Pentamethylene-N'-phenylurea;N-(Phenylcarbamoyl)piperidine; N-Phenyl-1-piperidinecarboxamide;N-Phenyl-N',N'-pentamethyleneurea; Urea, N,N-(1,5-pentanediyl)-N'-phenyl-
• CAS NO: 2645-36-5
• Molecular Formula: C12H16 N2 O
• Molecular Weight: 204.272
• Mol File: 2645-36-5.mol
• Article Data: 44

Chemical Properties

• CAS DataBase Reference: 1-Piperidinecarboxamide,N-phenyl-(CAS DataBase Reference)
• NIST Chemistry Reference: 1-Piperidinecarboxamide,N-phenyl-(2645-36-5)
• EPA Substance Registry System: 1-Piperidinecarboxamide,N-phenyl-(2645-36-5)

Safety Data

• Hazardous Substances Data: 2645-36-5(Hazardous Substances Data)

Usage

Compound class

Piperidinecarboxamides

Key features

Piperidine ring, carboxamide group

Usage

Pharmaceutical industry (intermediate in drug synthesis)

Drug applications

Anti-psychotics, anti-depressants, anti-anxiety medications

Other applications

Pesticides, agricultural chemicals

Safety concerns

Potential skin and eye irritation, harmful if swallowed or inhaled

Handling precautions

Handle with care in a controlled laboratory setting

Upstream product

• 110-89-4 piperidine 
• 60561-40-2 C₈H₈N₂O₂ 
• 113003-41-1 2-Oxo-azocane-1-carboxylic acid phenylamide 
• 201230-82-2 carbon monoxide 
• 622-37-7 Phenyl azide 
• 62-53-3 aniline 
• 15667-54-6 1-[phenyl(amino)carbonyl]hexahydro-2-azepinone 
• 1821-33-6 N-phenyl-N'-benzoylurea 
• 102-07-8 bis(diphenyl)urea 
• 103-71-9 phenyl isocyanate 
• 1003-67-4 4-methylpyridine-1-oxide 
• 1530-87-6 1-piperidinylcarbonnitrile 
• 37534-82-0 2,2,2-trichloroethyl phenylcarbamate 
• 1197040-29-1 phenyl isocyanate 

Downstream Products

• 63986-80-1 2-oxo-piperidine-1-carboxylic acid anilide 
• 105363-78-8 C₂₄H₃₀N₄O 
• 147-82-0 2,4,6-tribromoaniline 
• 634-83-3 2,3,4,5-tetrachloroaniline 
• 1008303-73-8 (2,3-diphenyl-indol-1-yl)(piperidin-1-yl)methanone 
• 102-07-8 bis(diphenyl)urea 
• 1274701-95-9 2-tert-butoxy-6-hydroxy-N-phenylpiperidine-1-carboxamide 
• 30543-37-4 N-phenyl-1-piperidinecarbimidoyl chloride 
• 13406-98-9 dihydropyridinemonocarboxylic acid 
• 62-53-3 aniline 
• 110-89-4 piperidine 
• 463-79-6 carbonic-acid 
• 72962-46-0 piperidinium hydrogen sulfate 
• 121-57-3 4-aminobenzene sulfonic acid 

Relevant articles and documents

Hydroamination and Hydrophosphination of Isocyanates/Isothiocyanates under Catalyst-Free Conditions

Symmetrical and unsymmetrical N,N’-disubstituted as well as trisubstituted ureas/thioureas by the hydroamination of isocyanates/isothiocyanates, and various phosphathioureas by the hydrophosphination of isothiocyanates have been synthesized in good to excellent yields under catalyst-free and mild conditions. This protocol is also applicable for the efficient synthesis of chiral ureas and thioureas and common herbicides, such as fenuron and monuron.

Lanthanum(III) Trifluoromethanesulfonate Catalyzed Direct Synthesis of Ureas from N-Benzyloxycarbonyl-, N -Allyloxycarbonyl-, and N -2,2,2-Trichloroethoxycarbonyl-Protected Amines

A novel lanthanum triflate mediated conversion of N -benzyloxycarbonyl-, N -allyloxycarbonyl-, and N -trichloroethoxycarbonyl-protected amines into nonsymmetric ureas was discovered. In this study, lanthanum triflate was found to be an effective catalyst for preparing various nonsymmetric ureas from protected amines. A variety of protected aromatic and aliphatic carbamates reacted readily with various amines in the presence of lanthanum triflate to generate the desired ureas in high yields. This result demonstrated that this novel lanthanum triflate catalyzed preparation of ureas from Cbz, Alloc, and Troc carbamates can be employed for the formation of various urea structures.

CaI2-Catalyzed direct transformation of: N -Alloc-, N -Troc-, and N -Cbz-protected amines to asymmetrical ureas

A novel and facile CaI2-catalyzed direct synthesis of asymmetrical ureas from N-Alloc-, N-Troc-, and N-Cbz-protected amines is developed. In this study, the efficient reaction of Alloc-, Troc-, and Cbz-carbamates with amines in the presence of catalytic CaI2 successfully generated various asymmetrical ureas. This catalytic synthetic procedure provided the desired ureas via reactions of these protected aromatic and aliphatic amines with various amines in high yields without side products. This suggests that novel direct synthesis of ureas from Alloc-, Troc-, and Cbz-carbamates can be a promising approach for the synthesis of useful ureas.