26614-48-2

Basic information

• Product Name: 17β-hydroxy-3-ethoxyandrosta-3,5-diene
• Synonyms: 17β-hydroxy-3-ethoxyandrosta-3,5-diene
• CAS NO: 26614-48-2
• Molecular Weight: 316.484
• Mol File: 26614-48-2.mol
• Article Data: 7

Chemical Properties

• CAS DataBase Reference: 17β-hydroxy-3-ethoxyandrosta-3,5-diene(CAS DataBase Reference)
• NIST Chemistry Reference: 17β-hydroxy-3-ethoxyandrosta-3,5-diene(26614-48-2)
• EPA Substance Registry System: 17β-hydroxy-3-ethoxyandrosta-3,5-diene(26614-48-2)

Safety Data

• Hazardous Substances Data: 26614-48-2(Hazardous Substances Data)

Usage

General Description

17β-hydroxy-3-ethoxyandrosta-3,5-diene is a synthetic androstenedione derivative that acts as a potent and selective inhibitor of the enzyme aromatase, which is responsible for the conversion of androgens to estrogens. By inhibiting aromatase, this compound effectively reduces the production of estrogen in the body, making it useful for research and potential therapeutic purposes. It has been investigated for its potential utility in treating estrogen-dependent cancers, such as breast cancer, as well as for its potential to enhance athletic performance by reducing estrogen levels and increasing testosterone production. Research on this chemical is ongoing, and more studies are needed to fully understand its potential benefits and side effects.

Upstream product

• 972-46-3 3-ethoxyandrosta-3,5-dien-17-one 
• 63-05-8 Androstenedione 
• 50-00-0 formaldehyd 
• 975-57-5 3,3-(ethylenedioxy)-5-androsten-17β-ol 
• 52091-99-3 3-ethoxy-17β-propionyloxy-androsta-3,5-diene 
• 71-23-8 propan-1-ol 
• 58-22-0 testosterone 
• 122-51-0 orthoformic acid triethyl ester 
• 74040-03-2 3-ethoxy-17-hydroxy-androsta-3,5-diene-17ξ-carbonitrile 

Downstream Products

• 58-22-0 testosterone 
• 315-37-7 testosterone heptanoate 
• 5949-44-0 testosterone undecanoate 
• 57-85-2 testosterone propionate 
• 1045-69-8 testosterone acetate 
• 52091-99-3 3-ethoxy-17β-propionyloxy-androsta-3,5-diene 
• 1778-93-4 testosterone enol diacetate 

Relevant articles and documents

Synthesis method of alkyl acid testosterone

The invention discloses a synthesis method of alkyl acid testosterone, and belongs to the technical field of synthesis and processing of medicines. The method comprises the following steps of: taking4-androstenedione (4AD) as an initial raw material, firstly, carrying out enol ether protection on the keto group at the site 3, and reducing carbonyl at the site 17 into hydroxyl; or taking 4-androstenedione (4AD) as an initial raw material, firstly carrying out enol ether protection on the keto group at the site 3, then reducing carbonyl at the site 17 into hydroxyl, then carrying out hydrolysison the site 3 to obtain testosterone, and carrying out esterification and third-site hydrolysis to obtain the testosterone ester after testosterone third-site ketal protection. According to the method disclosed by the invention, the third site is protected during esterification reaction, the generation of impurities can be reduced, and an esterification reaction solvent is a water-insoluble organic solvent, so that after the reaction is completed, products can be directly extracted in a layered manner, a large amount of water does not need to be added to separate out the products, the amountof wastewater is reduced, the solvent can be recycled, and the process is more suitable for industrial production.

PROCESS FOR PREPARATION OF TESTOSTERONE

The present invention relates to a process for purification of 4-androsten-3,17-dione (II) and its conversion to testosterone (I) having purity > 99 % as measured by HPLC.

1,2-Dehydrogenation of steroidal 6-methylen derivatives. Synthesis of exemestane

The development of an efficient dehydration method of steroidal 4-en-3-ones by using chloranil and BSTFA in the presence of triflic acid in refluxing toluene allowed us, starting from testosterone, to set a large-scale procedure for the synthesis of the anti-cancer drug exemestane in 70% overall yield.