26638-53-9Relevant articles and documents
Preparation method of intermediate for preparing tianeptine sodium
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, (2019/09/05)
The invention discloses a preparation method of an intermediate compound for preparing tianeptine sodium. The intermediate compound is shown as a formula. According to the synthesis method, p-chlorotoluene is used as a starting raw material to react with chlorosulfonic acid to obtain sulfonyl chloride, the sulfonyl chloride undergoes an amidation reaction with N-methylaniline under alkaline conditions to obtain sulfonamide, an aqueous solution of the sulfonamide and air are continuously pumped into a fixed bed reactor loaded with an immobilized catalyst according to a certain ration for oxidation to obtain carboxylic acid, and then the carboxylic acid is subjected to cyclization under catalysis of a solid acid to obtain the target compound. The method has simple and few steps, the cost ofthe raw materials is low, the fixed bed reactor and the solid acid catalyst are utilized, the catalyst can be repeatedly recycled to reduce the discharge of the three wastes, the production process isenvironmentally friendly, and the method is more suitable for industrial production.
A process for the preparation of intermediates tianeptine sodium
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Paragraph 0036-0040, (2017/03/08)
The invention discloses a method for preparing a tianeptine sodium intermediate 3-chloro-6-methyl dibenzo[c, f][1, 2] thiazepine-11-(6H)-ketone 5,5-dioxide. 4-chloro-2-(N-methyl-N-phenyl-sulfamoyl)-methyl benzoate is taken as a raw material for synthesizi