266678-13-1

Basic information

• Product Name: 4-(2-Methoxy-phenyl)-1H-indole
• Synonyms: 4-(2-Methoxy-phenyl)-1H-indole
• CAS NO: 266678-13-1
• Molecular Formula: C₁₅H₁₃NO
• Molecular Weight: 223
• Mol File: 266678-13-1.mol
• Article Data: 4

Chemical Properties

• Boiling Point: 387.8±17.0 °C(Predicted)
• Appearance: /
• Density: 1.167±0.06 g/cm3(Predicted)
• PKA: 16.89±0.30(Predicted)
• CAS DataBase Reference: 4-(2-Methoxy-phenyl)-1H-indole(CAS DataBase Reference)
• NIST Chemistry Reference: 4-(2-Methoxy-phenyl)-1H-indole(266678-13-1)
• EPA Substance Registry System: 4-(2-Methoxy-phenyl)-1H-indole(266678-13-1)

Safety Data

• Hazardous Substances Data: 266678-13-1(Hazardous Substances Data)

Upstream product

• 52488-36-5 4-bromo-1H-indole 
• 5720-06-9 2-Methoxyphenylboronic acid 
• 212119-12-5 4-(2-methoxyphenyl)-2,3-dihydro-1H-indole 
• 55289-35-5 2-bromo-6-nitrotoluene 
• 266678-14-2 2'-Methoxy-2-methyl-3-nitro-biphenyl 

Downstream Products

• 1383973-93-0 2-{2-[4-(2-methoxyphenyl)-2,3-dihydro-1H-indol-1-yl]-2-oxoethyl}-6-(morpholin-4-yl)pyrimidin-4(3H)-one 
• 212119-12-5 4-(2-methoxyphenyl)-2,3-dihydro-1H-indole 

Relevant articles and documents

Regioselective Formation of Substituted Indoles: Formal Synthesis of Lysergic Acid

A Diels–Alder reaction-based strategy for the synthesis of indoles and related heterocycles is reported. An intramolecular cycloaddition of alkyne-tethered 3-aminopyrones gives 4-substituted indolines in good yield and with complete regioselectivity. Additional substitution is readily tolerated in the transformation, allowing synthesis of complex and non-canonical substitution patterns. Oxidative conditions give the corresponding indoles. The strategy also allows the synthesis of carbazoles. The method was showcased in a formal synthesis of lysergic acid.

Synthesis of the 4-arylindole portion of the antitumor agent diazonamide and related studies

The synthesis of 6 comprising the CDG rings of the diazonamides was achieved in an overall yield of 75% from commercially available 3. (C) 2000 Elsevier Science Ltd.