266686-81-1Relevant articles and documents
Tacilol isomer impurity PY3 and preparation method and use thereof
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Paragraph 0028; 0033, (2018/07/07)
The present invention discloses a tacilol isomer impurity PY3 and a preparation method thereof, and belongs to the chemical pharmaceutical technical field. The tacilol isomer impurity PY3 is (1beta, 3beta, 5Z, 7E, 22E)-9,10-secoergosta-5, 7, 10 (19), 22-tetraen-1,3-diol. The high-purity alfacalcidol-related impurity PY3 can be used as an impurity standard in the detection and analysis of an alfacalcidol finished product, accurate positioning and characterization of impurities in the detection and analysis of the alfacalcidol finished product can be promoted, enhancement of control of the impurities can be facilitated, and the quality of the alfacalcidol finished product can be improved. The method has the advantages of low cost and easy availability of raw materials, simple operation and good reproducibility, and the HPLC purity is >=99.5%.
Synthesis of 24(28)-methylene-1α-hydroxyvitamin D3, a novel vitamin D3 analogue
Guo, Wei,Fang, Zhijie,Li, Hongliang,Liu, Yanan
, p. 231 - 235 (2014/05/06)
24(28)-Methylene-1α-hydroxyvitamin D3 was synthesised in 13 steps from vitamin D2. The key step of the synthesis involved the Wittig-Horner olefination of a nor-vitamin D2 aldehyde with diethylphosphono-3-methyl-2-butanone
Reductive alkylation of a selenoacetal in the elaboration of steroid side chains: Stereochemistry and application in a synthesis of 1α-hydroxyvitamin D3
Calverley
, p. 1337 - 1340 (2007/10/02)
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