2673-19-0

Basic information

• Product Name: H-ASP(OTBU)-OME HCL
• Synonyms: ASPARTIC ACID(OTBU)-OME HCL;H-ASP(OTBU)-OME HCL;H-ASP(OTBU)-OME HYDROCHLORIDE;H-ASP(OBUT)-OME HCL;L-ASPARTIC ACID BETA-T-BUTYL ESTER ALPHA-METHYL ESTER HYDROCHLORIDE;L-ASPARTIC ACID BETA-T-BUTYL, ALPHA-METHYL-DIESTER HYDROCHLORIDE;L-ASPARTIC ACID BETA-T-BUTYL ALPHA-METHYL ESTER HYDROCHLORIDE;L-ASPARTIC ACID BETA-T-BUTYL ALPHA-METHYL ESTER HYDROCHLORIDE SALT
• CAS NO: 2673-19-0
• Molecular Formula: C₉H₁₇NO₄*ClH
• Molecular Weight: 239.7
• Product Categories: Amino Acid Derivatives;Amino Acids;Aspartic Acid;Amino Acid Derivatives;Peptide Synthesis
• Mol File: 2673-19-0.mol

Chemical Properties

• Melting Point: 167 °C (decomp)
• Boiling Point: 301.1 °C at 760mmHg
• Flash Point: 135.9 °C
• Appearance: /Solid
• Vapor Pressure: 0.000807mmHg at 25°C
• Storage Temp.: 2-8°C
• BRN: 6005591
• CAS DataBase Reference: H-ASP(OTBU)-OME HCL(CAS DataBase Reference)
• NIST Chemistry Reference: H-ASP(OTBU)-OME HCL(2673-19-0)
• EPA Substance Registry System: H-ASP(OTBU)-OME HCL(2673-19-0)

Safety Data

• WGK Germany: 3
• Hazardous Substances Data: 2673-19-0(Hazardous Substances Data)

Usage

Chemical Properties

White to off-white powder

InChI:InChI=1/C9H17NO4.ClH/c1-9(2,3)14-7(11)5-6(10)8(12)13-4;/h6H,5,10H2,1-4H3;1H/t6-;/m1./s1

Upstream product

• 63327-57-1 (2S), 2-benzyloxycarbonylamino-succinic acid 1-methyl ester 4-tertiobutyl ester 
• 39895-10-8 L-aspartic acid β-tert-butyl ester α-methyl ester 

Downstream Products

• 14470-59-8 [(N-benzyloxycarbonyl)leucinyl]aspartic acid, β-tert-butyl, α-methyl ester 
• 1676-90-0 Boc-Asp(OtBu)-OH 
• 3190-64-5 (S)-2-((S)-2-Benzyloxycarbonylamino-propionylamino)-succinic acid 4-tert-butyl ester 1-methyl ester 
• 328236-09-5 2-[(1-{4-[(3,5-dimethyl-phenylcarbamoyl)-methyl]-phenoxy}-cyclopentanecarbonyl)-amino]-succinic acid 4-tert-butyl ester 1-methyl ester 
• 856865-56-0 N-(o-nitrobenzenesulfonyl)-L-aspartic acid β-t-butyl ester methyl ester 
• 1005751-84-7 (S)-2-{2-[2-(2-tert-butyl-benzyl)-3-oxo-2,3-dihydro-pyridazin-4-yl]-butyrylamino}-succinic acid 4-tert-butyl ester 1-methyl ester 
• 856865-71-9 N-methyl-N-(o-nitrobenzenesulfonyl)-L-aspartic acid β-t-butyl ester methyl ester 
• 856865-93-5 N-α-methyl-N-α-(o-nitrobenzenesulfonyl)-L-aspartic acid β-t-butyl ester 
• 610314-19-7 2-(4-methoxy-benzylamino)-succinic acid 4-tert-butyl ester 1-methyl ester 
• 3408-50-2 [(N-benzyloxycarbonyl)-L-alaninyl]-L-aspartic acid [beta]-tert-butyl ester 
• 204919-57-3 methyl ((benzyloxy)carbonyl)-L-valyl-L-(O-tert-butyl)aspartate 
• 208330-82-9 N-[N-(3,4dichlorophenyl)-D,L-alanyl]-L-aspartic β-(tert-butyl ester)α-methyl ester 
• 1033712-98-9 4-tert-Butyl 1-Methyl N-[2-(benzyloxy)-2-oxoethyl]-L-aspartate 
• 1172602-28-6 C₁₇H₂₃NO₅ 

Relevant articles and documents

A polypeptide material aspartic acid tert-butyl β - α - methyl ester hydrochloride preparation method

The invention discloses a polypeptide material aspartic acid tert-butyl β - α - methyl ester hydrochloride of the preparation method, is mainly composed of complex technology, cycle is long, the yield is low, the cost is high, the risk is high, does not meet the technical problems of production and the like. Preparation method of this invention comprises the following steps: 1st step, the aspartic acid suspended in dry tetrahydrofuran, in phosphorus oxychloride under the action of the aspartic acid in the preparation into the anhydride hydrochloride; 2nd step, aspartic acid anhydride hydrochloride suspended in methanol reaction to obtain the aspartic acid α - methyl ester hydrochloride, triethylamine for adjusting pH value so that the aspartic acid methyl α - separated out; 3rd step, aspartic acid methyl α - suspended in methylene chloride, access isobutene, concentrated sulfuric, sealed reaction to obtain the oil of aspartic acid tert-butyl methyl α - β -; 4th step, the oil of aspartic acid tert-butyl methyl α - β - dissolved in ethyl ether, dropping ethyl ether - hydrochloric acid gas, the final product is obtained α - β - tert-butyl aspartic acid methyl ester hydrochloride.

CASPASE INHIBITORS BASED ON PYRIDAZINONE SCAFFOLD

The present invention relates to a pyridazinone derivative which can be used as a caspase inhibitor, process for the preparation thereof, and pharmaceutical composition for inhibiting caspase comprising the same.

Isoxazoline derivative and a process for the preparation thereof

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