2678-54-8Relevant articles and documents
Fields,D.L. et al.
, p. 390 - 395 (1968)
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Fukuda,M. et al.
, p. 2103 - 2105 (1975)
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Photoinduced Cross-Coupling of Aryl Iodides with Alkenes
Liu, Yuliang,Li, Haoyu,Chiba, Shunsuke
supporting information, p. 427 - 432 (2021/01/26)
A protocol for photoinduced cross-coupling of aryl iodides having polar π-functional groups or elongated π-conjugation with alkenes has been developed. The radical cascade mechanism involving generation of aryl radicals via C-I bond homolysis of photoexcited aryl iodides and their subsequent addition to alkenes is proposed. The method enables iodide-selective cross-coupling over other halogen leaving groups with functional group compatibility on both arene and alkene motifs.
Design, Synthesis, and Evaluation of a Series of Novel Benzocyclobutene Derivatives as General Anesthetics
Zhang, Chen,Li, Fangqiong,Yu, Yan,Huang, Anbang,He, Ping,Lei, Ming,Wang, Jianmin,Huang, Longbin,Liu, Zhenhong,Liu, Jianyu,Wei, Yonggang
supporting information, p. 3618 - 3625 (2017/05/19)
In the present work, a series of structurally novel benzocyclobutene derivatives were identified as general anesthetics through the loss of righting reflex (LORR) experiment on mice. Our initial efforts found compound 1a with a fused four-membered ring on the 2,3-position of the phenol ring could significantly improve the safety profile. Further SAR study revealed that small hydrogen bond acceptor (HBA) groups are optimal for good ED50 along with much broader therapeutic windows, such as compounds 16b and 17. Present work demonstrates the superiority of this novel benzocyclobutene scaffold.
Process for the synthesis of 3,4-dimethoxybicyclo[4.2.0]OCTA-1,3,5-triene-7-carbonitrile, and application in the synthesis of ivabradine and addition salts thereof with a pharmaceutically acceptable acid
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Page/Page column 5; 6, (2014/10/29)
Process for the synthesis of the compound of formula (I): Application in the synthesis of ivabradine, addition salts thereof with a pharmaceutically acceptable acid and hydrates thereof.