2687-94-7 Usage
Synthesis
N-Octyl pyrrolidone was synthesized by 2-pyrrolidone and tetrabutylammonium bromide stirred with adding n-octane chloride for 10 h at 90 °C.
Chemical Properties
Colorless or slightly yellow clear liquid
Uses
N-Octyl pyrrolidone(NOP) is a highly efficient and selective solvent, which can be used in the recovery of organic raw materials, the refining of lubricating oils, and the solvent for polymers and polymerization reactions; It is also widely used in chemical synthesis reactions.
Synthesis Reference(s)
Different sources of media describe the Synthesis Reference(s) of 2687-94-7 differently. You can refer to the following data:
1. The Journal of Organic Chemistry, 57, p. 3328, 1992 DOI: 10.1021/jo00038a019
2. The Journal of Organic Chemistry, 59, p. 6378, 1994 DOI: 10.1021/jo00100a046
General Description
1-Octyl-2-pyrrolidone is a permeation enhancer and its effect in transport of steroidal permeants across hairless mouse skin was investigated via a parallel pathway skin model.
Flammability and Explosibility
Nonflammable
Safety Profile
Moderately toxic by ingestion. Asevere skin and eye irritant. A corrosive. Combustibleliquid. When heated to decomposition it emits toxic fumesof NOx.
Check Digit Verification of cas no
The CAS Registry Mumber 2687-94-7 includes 7 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 4 digits, 2,6,8 and 7 respectively; the second part has 2 digits, 9 and 4 respectively.
Calculate Digit Verification of CAS Registry Number 2687-94:
(6*2)+(5*6)+(4*8)+(3*7)+(2*9)+(1*4)=117
117 % 10 = 7
So 2687-94-7 is a valid CAS Registry Number.
InChI:InChI=1/C12H23NO/c1-2-3-4-5-6-7-10-13-11-8-9-12(13)14/h2-11H2,1H3
2687-94-7Relevant articles and documents
Extension of the Eschweiler-Clarke procedure to the N-alkylation of amides
Fache, Fabienne,Jacquot, Laurent,Lemaire, Marc
, p. 3313 - 3314 (1994)
The selective N-alkylation of amides (cyclic or acyclic) under hydrogen is reported using aldehydes or ketones as alkylating agents and Pd/C/Na2SO4 as catalyst. Good isolated yields are obtained (81% to 98%).
Process for the preparation of N-substituted lactams
-
, (2008/06/13)
The invention relates to a process for the preparation of N-substituted lactams by reaction of a lactam, which is unsubstituted on the nitrogen, with an organic halide in the presence of at least one solid-liquid phase transfer catalyst, such as a quaternary ammonium salt, and of at least one solid inorganic base, such as an alkali metal hydroxide, and in the absence of solvent. By this process, N-substituted lactams are obtained with good yields and high purity. The absence of solvent makes possible a considerable gain in productivity and an improvement in safety and in regard for the environment.
N-allyl-lactams as crystallization inhibitors
-
, (2008/06/13)
Crystallization of active material in spraying of an aqueous solution of certain specified fungicides is retarded by incorporation therein of an N-alkyl-lactam of the formula STR1 in which R represents alkyl having 6 to 18 carbon atoms and n represents the numbers 3, 4 or 5.