2703-17-5Relevant articles and documents
Functionalization of 2-Trifluoromethyl-1H-pyrrole: A Convenient Entry into Advanced Fluorinated Building Blocks Including all Isomeric 2-(Trifluoromethyl)prolines
Hys, Vasyl Yu.,Shevchuk, Oleksandr I.,Vashchenko, Bohdan V.,Karpenko, Oleksandr V.,Gorlova, Alina O.,Grygorenko, Oleksandr O.
, p. 3896 - 3905 (2020)
The synthetic utility of 2-trifluoromethyl-1H-pyrrole as a pharmaceutically relevant platform was demonstrated by the preparation of mono- and bifunctional C-2(5)- or C-3-substituted derivatives, i.e. regioisomeric sulfonyl halides, carboxylic acids, aldehydes, and nitriles. A series of modifications relied on lithiation or electrophilic substitution, which proceeded regioselectively on multigram scale, mostly in protecting-group-free mode. Subsequent catalytic hydrogenation of the pyrrole ring was also performed for synthesis of all isomeric 2-trifluoromethyl α- and β-prolines. These derivatives were considered as promising low-molecular-weight building blocks for synthesis, drug discovery, and agrochemistry.
NOVEL OXADIAZOLE COMPOUNDS CONTAINING 5- MEMBERED HETEROAROMATIC RING FOR CONTROLLING OR PREVENTING PHYTOPATHOGENIC FUNGI
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Page/Page column 74, (2021/02/26)
The present invention relates to a compound of formula (I), wherein, R1,A, A5, A6, A7, A8, R12, n and Q are as defined in the detailed description and a process for preparing the compound of formula (I).The present invention also relates to a method for controlling or preventing phytopathogenic fungi.
SULFONAMIDE COMPOUNDS AND THE USE THEREOF IN THE TREATMENT OF CANCER
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Paragraph 00181, (2021/04/23)
The present disclosure relates generally to a class of sulfonamide-based compounds, compositions containing the same and the therapeutic use of the compounds in the treatment of cancer.