27036-49-3

Basic information

• Product Name: 2,5-Pyrrolidinedione, 1-phenyl-3-(phenylamino)-
• CAS NO: 27036-49-3
• Molecular Formula: C16H14N2O2
• Molecular Weight: 266.299
• Mol File: 27036-49-3.mol
• Article Data: 3

Chemical Properties

• CAS DataBase Reference: 2,5-Pyrrolidinedione, 1-phenyl-3-(phenylamino)-(CAS DataBase Reference)
• NIST Chemistry Reference: 2,5-Pyrrolidinedione, 1-phenyl-3-(phenylamino)-(27036-49-3)
• EPA Substance Registry System: 2,5-Pyrrolidinedione, 1-phenyl-3-(phenylamino)-(27036-49-3)

Safety Data

• Hazardous Substances Data: 27036-49-3(Hazardous Substances Data)

Usage

Class

Synthetic nootropic compound

Type of drug

Racetam

Effects

Potential cognitive-enhancing effects, improves memory, learning, and various aspects of cognitive function

Chemical structure

Includes a phenyl ring and an amino substituent

Mechanism of action

Believed to modulate the levels of neurotransmitters in the brain

Properties

May have stimulant and anti-amnesic properties

Potential use

Treatment of neurological disorders and neurodegenerative diseases (requires further research)

Upstream product

• 62-53-3 aniline 
• 141-05-9 Diethyl maleate 
• 624-48-6 dimethyl cis-but-2-ene-1,4-dioate 
• 541-59-3 maleiimide 
• 108-31-6 maleic anhydride 
• 95-50-1 1,2-dichloro-benzene 
• 77500-28-8 N,N'-diphenyl-fumaramide 
• 110-17-8 (2E)-but-2-enedioic acid 
• 110-16-7 maleic acid 
• 763-51-9 diethyl 2-bromosuccinate 
• 923-06-8 bromosuccinic acid 
• 617-48-1 malic acid 
• 70-47-3 L-asparagine 
• 3052-50-4 monomethyl maleate 

Downstream Products

• 41260-58-6 2-(2-oxo-4-phenyl-morpholin-3-yl)-N-phenyl-acetamide 
• 115370-56-4 3-phenylimino-4-dimethylaminomethylene-N-phenylsuccinimide 
• 120933-61-1 2-anilino-3-formyl-N-phenylmaleimide 
• 10351-61-8 N-phenylacridinimide 
• 2226-83-7 N-phenyl-DL-aspartic acid ; inactive anilinosuccinic acid 
• 62-53-3 aniline 
• 134667-18-8 4-Hydroxy-N-phenyl-3-phenylamino-butyramide 
• 13797-26-7 3-anilino-1-phenyl-pyrrole-2,5-dione 

Relevant articles and documents

Deep Eutectic Solvent Choline Chloride/ p-toluenesulfonic Acid and Water Favor the Enthalpy-Driven Binding of Arylamines to Maleimide in Aza-Michael Addition

Deep eutectic solvents (DESs) have been considered the organic reaction medium of the century because they can be used as solvents and active catalysts in chemical reactions. However, experimental and theoretical studies are still needed to provide information on the structures of DESs, the kinetics and thermodynamics properties, the interactions between the DESs and the substrates, the effect of water on the DES supramolecular network and its physicochemical properties, and so forth. This information is very useful to understand the essence of the processes that take place in the catalysis of chemical reactions and, therefore, to help in the design of a DES for a specific reaction and sample. This article shows a systematic study of the impact of DES choline chloride/p-toluenesulfonic acid and DES choline chloride/p-toluenesulfonic acid-water in the aza-Michael addition of arylamines to maleimide to obtain aminopyrrolidine-2,5-dione derivatives. The derivatives are obtained under very mild reaction conditions with good yield. The global reaction is exothermic, spontaneous, permitted by enthalpy, and prohibited for entropy. The calculated potential energy surface shows a reaction mechanism of six steps controlled by enthalpy (except the last step that is controlled by entropy). The water incorporated in the supramolecular DES complex stabilizes the transition states and favors the enthalpy-driven binding. A set of H/D exchange NMR experiments validates the transition state existing in the fourth stage of the mechanism.

Method for the preparation of quinoline-2,3-dicarboxylic acid

The present invention relates to novel methods for the preparation of quinoline-2,3-dicarboxylic acid, useful for the preparation of the highly effective 2-(2-imidazolin-2-yl)quinoline-3-carboxylic acid herbicidal agents.