27049-64-5Relevant articles and documents
Discovery of Novel Inhibitors of Uridine Diphosphate- N-Acetylenolpyruvylglucosamine Reductase (MurB) from Pseudomonas aeruginosa, an Opportunistic Infectious Agent Causing Death in Cystic Fibrosis Patients
Abell, Chris,Acebrón-García-De-Eulate, Marta,Blundell, Tom L.,Brown, Karen P.,Coyne, Anthony G.,Di Pietro, Ornella,Floto, R. Andres,Hess, Jeannine,Holland, Matthew T. O.,Kim, So Yeon,Marchetti, Chiara,Mayol-Llinàs, Joan,Mendes, Vitor
, p. 2149 - 2173 (2022/02/14)
Pseudomonas aeruginosa is of major concern for cystic fibrosis patients where this infection can be fatal. With the emergence of drug-resistant strains, there is an urgent need to develop novel antibiotics against P. aeruginosa. MurB is a promising target
DNDI-6148: A Novel Benzoxaborole Preclinical Candidate for the Treatment of Visceral Leishmaniasis
Bello, Davide,Braillard, Stéphanie,Caljon, Guy,Carvalho, Sandra,Corpas-Lopez, Victoriano,Freund, Yvonne,Gilbert, Ian H.,Glossop, Paul A.,Jacobs, Robert T.,Lukac, Iva,Maes, Louis,Mowbray, Charles E.,Nare, Bakela,Pandi, Bharathi,Patterson, Stephen,Speake, Jason,Van Den Kerkhof, Magali,Wall, Richard J.,Whitlock, Gavin A.,Wyllie, Susan,Yardley, Vanessa,Zuccotto, Fabio
supporting information, p. 16159 - 16176 (2021/11/16)
Visceral leishmaniasis (VL) is a parasitic disease endemic across multiple regions of the world and is fatal if untreated. Current therapies are unsuitable, and there is an urgent need for safe, short-course, and low-cost oral treatments to combat this ne
Selective Synthesis of Functionally Substituted 1,2,3-Triazoles
Golobokova, T. V.,Kizhnyaev, V. N.,Proidakov, A. G.
, p. 446 - 453 (2020/04/27)
Abstract: Different conditions were used to achieve selective formation of4.5-disubstituted 1-aryl(hetaryl)-1,2,3-triazoles via cycloaddition of thecorresponding enolates and aryl or hetaryl azides. Optimal conditions were foundfor the bromination of 1-(5
