27292-49-5

Basic information

• Product Name: 3-MORPHOLINOPHENOL
• Synonyms: 3-MORPHOLINOPHENOL;3-(4-MORPHOLINO)PHENOL;4-(3-Hydroxyphenyl)morpholine;3-Morpholin-4-ylphenol;3-MORPHOLINOBENZOICACID;3-(4-Morpholinyl)phenol, 98%;Phenol, 3-(4-Morpholinyl)-;M-Morpholinophenol
• CAS NO: 27292-49-5
• Molecular Formula: C₁₀H₁₃NO₂
• Molecular Weight: 179.22
• Product Categories: pharmacetical
• Mol File: 27292-49-5.mol
• Article Data: 11

Chemical Properties

• Melting Point: 136 °C
• Boiling Point: 362.6 °C at 760 mmHg
• Flash Point: 173.1 °C
• Appearance: /
• Density: 1.185 g/cm³
• Vapor Pressure: 9.18E-06mmHg at 25°C
• Refractive Index: 1.574
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 10.27±0.10(Predicted)
• BRN: 149989
• CAS DataBase Reference: 3-MORPHOLINOPHENOL(CAS DataBase Reference)
• NIST Chemistry Reference: 3-MORPHOLINOPHENOL(27292-49-5)
• EPA Substance Registry System: 3-MORPHOLINOPHENOL(27292-49-5)

Safety Data

• Hazard Codes: Xi,Xn
• Statements: 36/37/38-22
• Safety Statements: 26-36/37/39
• WGK Germany: 3
• Hazardous Substances Data: 27292-49-5(Hazardous Substances Data)

Usage

General Description

3-MORPHOLINOPHENOL, also known as 3-morpholin-4-ylphenol, is a chemical compound that is commonly used as an intermediate for the synthesis of pharmaceuticals, dyes, and rubber accelerators. It is a white to off-white crystalline solid that is insoluble in water but soluble in organic solvents. 3-MORPHOLINOPHENOL is also used as an inhibitor in the production of polyester resins and as a corrosion inhibitor for metals. It is important to handle this compound with care, as it can cause irritation to the skin, eyes, and respiratory system upon contact. Additionally, it may be harmful if ingested or inhaled, and adequate safety precautions should be taken when working with this chemical.

InChI:InChI=1/C10H13NO2/c12-10-3-1-2-9(8-10)11-4-6-13-7-5-11/h1-3,8,12H,4-7H2

Upstream product

• 110-91-8 morpholine 
• 108-46-3 recorcinol 
• 111-44-4 3-oxa-1,5-dichloropentane 
• 591-27-5 m-Hydroxyaniline 
• 106-41-2 4-bromo-phenol 
• 108-43-0 3-monochlorophenol 
• 26926-56-7 4-(3-benzyloxy-phenyl)-morpholine 
• 16179-67-2 3-morpholin-4-yl-cyclohex-2-enone 
• 53087-13-1 3-(benzyloxy)phenyl bromide 
• 159724-40-0 3-morpholine-4-ylaniline 
• 108-94-1 cyclohexanone 
• 5414-19-7 1,1'-oxybis(2-bromo-ethane) 

Downstream Products

• 404010-44-2 2-chloro-1-(2-hydroxy-4-morpholin-4-yl-phenyl)-ethanone 
• 70362-07-1 2-hydroxy-4-morpholin-4-yl-benzaldehyde 
• 37893-38-2 2-hydroxy-4-morpholinobenzamide 
• 183307-22-4 3-[(3,5-difluoro-4-methyl-6-(3-(morpholin-4-yl)phenoxy)pyridin-2-yl)oxy]benzonitrile 
• 313655-18-4 2-[3-(4-Morpholinyl)phenoxy]ethyl 3-(1-piperazinyl)-2-pyrazinyl Ether 
• 1620293-44-8 4-(3-(allyloxy)phenyl)morpholine 
• 1152500-29-2 C₁₄H₁₉NO₂ 
• 205494-27-5 (3S,4R)-3-{N-benzyloxycarbonyl-β-(2-naphthyl)-L-alanyl}-amino-4-{3-(morpholin-4-yl)-phenoxy}-azetidin-2-one 
• 597584-59-3 3-morpholin-4-ylphenyl trifluoromethanesulfonate 
• 25912-15-6 2-amino-5-morpholinophenol 
• 404009-46-7 AMA₃₇ 
• 404009-40-1 IC₈₆₆₂₁ 
• 27292-55-3 5-morpholin-4-yl-2-nitroso-phenol 
• 37895-05-9 1-morpholin-4-yl-3-phenylcarbamoyloxy-benzene 

Relevant articles and documents

A novel morpholine-based rhodamine fluorescent chemosensor for the rapid detection of Hg2+ ions

A novel rhodamine-based receptor bearing a morpholine (RDM) was developed as a fluorescent chemosensor with high selectivity toward Hg2+. After the addition of Hg2+ to RDM, the color of the solution changed from colorless to pink, and the new absorption band appears at 580 nm. The fluorescent of RDM appears to orange color in the presence of Hg2+. Upon the addition of Hg2+, ring-opening of the corresponding spirolactam gives rise to fluorescence, and a 1:1 metal-ligand complex formed.

Intermolecular Multiple Dehydrogenative Cross-Couplings of Ketones with Boronic Acids and Amines via Copper Catalysis

An efficient and versatile oxidative coupling reaction was developed for the synthesis of valuable β-functionalized unsaturated ketones and meta-substituted phenols. In the case of intramolecular reactions, achieving rapid molecular complexity through multiple dehydrogenative couplings is already a well-established strategy. Herein, we report an intermolecular multiple dehydrogenative coupling between ketones and nucleophilic amines or boronic acids using inexpensive copper(I) oxide as a catalyst. This method provides a facile access to highly desirable chemical products such as α,β-unsaturated ketones, enaminones, and synthetically relevant meta-substituted phenols. (Figure presented.).

Method for continuously synthesizing meta-di-alkane aminophenol

The invention discloses a method for continuously synthesizing meta-di-alkane aminophenol. The technical scheme includes that continuous diazotization or continuous diazonium salt hydrolysis or continuous diazotization and diazonium salt hydrolysis is carried on raw materials such as di-alkane aminophenol, sodium nitrite and sulfuric acid, and after-treatment such as extraction is carried out to obtain the meta-di-alkane aminophenol which is a product. The method has the advantages that the raw materials can come from sufficient sources and are low in cost, processes for synthesizing the meta-di-alkane aminophenol are high in safety, products are high in yield, the method is little in waste gas, wastewater and industrial residue pollution, is green and environmental friendly and has a highindustrialization value, and the like.