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274-80-6

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274-80-6 Usage

General Description

1,7,8-triazabicyclo[4.3.0]nona-2,4,6,8-tetraene is a complex organic compound that belongs to the group of azabicyclo compounds. These compounds are organic substances that comprise two fused ring structures, with at least one nitrogen atom as a component of the bicyclic unit. The structure of 1,7,8-triazabicyclo[4.3.0]nona-2,4,6,8-tetraene is characterized by a tetraene moiety and a triaza-donor system, making it highly reactive under certain conditions. Despite the complexity of its name and structural formula, extensive information about its chemical and physical properties, safety data, as well as potential usage in specific applications, may not be readily found in general literature.

Check Digit Verification of cas no

The CAS Registry Mumber 274-80-6 includes 6 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 3 digits, 2,7 and 4 respectively; the second part has 2 digits, 8 and 0 respectively.
Calculate Digit Verification of CAS Registry Number 274-80:
(5*2)+(4*7)+(3*4)+(2*8)+(1*0)=66
66 % 10 = 6
So 274-80-6 is a valid CAS Registry Number.
InChI:InChI=1/C6H5N3/c1-2-4-9-5-7-8-6(9)3-1/h1-5H

274-80-6SDS

SAFETY DATA SHEETS

According to Globally Harmonized System of Classification and Labelling of Chemicals (GHS) - Sixth revised edition

Version: 1.0

Creation Date: Aug 19, 2017

Revision Date: Aug 19, 2017

1.Identification

1.1 GHS Product identifier

Product name Pyrido[2,1-c]-1,2,4-triazole

1.2 Other means of identification

Product number -
Other names benzoisotriazole

1.3 Recommended use of the chemical and restrictions on use

Identified uses For industry use only.
Uses advised against no data available

1.4 Supplier's details

1.5 Emergency phone number

Emergency phone number -
Service hours Monday to Friday, 9am-5pm (Standard time zone: UTC/GMT +8 hours).

More Details:274-80-6 SDS

274-80-6Relevant articles and documents

Nitroalkanes as electrophiles: Synthesis of triazole-fused heterocycles with neuroblastoma differentiation activity

Aksenov, Alexander V.,Aksenov, Dmitrii A.,Aksenov, Nicolai A.,Arutiunov, Nikolai A.,Du, Liqin,Kirilov, Nikita K.,Kornienko, Alexander,Maslivetc, Vladimir,Rubin, Michael,Zhao, Zhenze

, p. 6651 - 6664 (2020/09/21)

We discovered a reaction of nitroalkanes with 2-hydrazinylquinolines, 2-hydrazinylpyridines and bis-2,4-dihydrazinylpyrimidines in polyphosphoric acid (PPA) affording 1,2,4-triazolo[4,3-a]quinolines, 1,2,4-triazolo[4,3-a]pyridines and bis[1,2,4]triazolo[4,3-a:4′,3′-c]pyrimidines, respectively. The reaction expands the scope of heterocyclic annulations involving phosphorylated nitronates, believed to be the electrophilic intermediates formed from nitroalkanes in PPA. Several of the synthesized triazoles showed promising anticancer activity by inducing differentiation in neuroblastoma cancer cells. Due to the urgent need for novel differentiation agents for neuroblastoma therapy, this finding warrants further evaluation of this class of compounds against neuroblastoma.

Metal free [4+1] and [5+1] annulation reactions to prepare heterocycles using DMF and its derivatives as one-carbon source

Liu, Lingfeng,Qiao, Chunhua,Shen, Bei,Xu, Yiwen

supporting information, (2020/04/01)

1,2,4-Triazolo[3,4-a]pyridines and related heterocycles and substituted triazines were commonly discovered scaffolds in a variety of pharmaceutical and agrochemical agents. Herein, we report a highly efficient and practical method using DMF and its derivative for the [4+1] and [5+1] annulation reactions to prepare these heterocycles. This metal free reaction takes advantages of shelf stable DMF as solvent and carbon donor, imidazole chloride as a catalyst, the mild reaction condition tolerates a broad substrate range and substitutes. The prepared 3-unsubstituted 1,2,4-triazolo[3,4-a]pyridine and derivatives allow further introduction of a variety of functional group1 at 3-position.

Synthesis of 1,2,4-Triazolo[4,3-a]pyridines and Related Heterocycles by Sequential Condensation and Iodine-Mediated Oxidative Cyclization

Li, Ertong,Hu, Zhiyuan,Song, Lina,Yu, Wenquan,Chang, Junbiao

, p. 11022 - 11027 (2016/07/27)

A facile and efficient approach to access 1,2,4-triazolo[4,3-a]pyridines and related heterocycles has been accomplished through condensation of readily available aryl hydrazines with corresponding aldehydes followed by iodine-mediated oxidative cyclizatio

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