27492-84-8

Basic information

• Product Name: Methyl 4-amino-2-methoxybenzoate
• Synonyms: METHYL 4-AMINO-2-METHOXYBENZENECARBOXYLATE;METHYL 4-AMINO-2-METHOXYBENZOATE;4-AMINO-2-METHOXYBENZOIC ACID METHYL ESTER;methyl 4-amino-o-anisate;Methyl 4-amino-2-methoxybenzoate, 95+%;4-Amino-o-anisic acid methyl ester;4-Amino-2-methoxybenzoic Acid Methyl Ester Methyl 4-Amino-o-anisate 4-Amino-o-anisic Acid Methyl Ester;Benzoic acid, 4-aMino-2-Methoxy-, Methyl ester
• CAS NO: 27492-84-8
• Molecular Formula: C₉H₁₁NO₃
• Molecular Weight: 181.19
• EINECS: 248-494-9
• Product Categories: Aromatic Esters;C8 to C9;Carbonyl Compounds;Esters;Amines;Aromatics;Intermediates
• Mol File: 27492-84-8.mol
• Article Data: 21

Chemical Properties

• Melting Point: 155-159 °C(lit.)
• Boiling Point: 339.2 °C at 760 mmHg
• Flash Point: 181.8 °C
• Appearance: /
• Density: 1.179 g/cm³
• Vapor Pressure: 9.36E-05mmHg at 25°C
• Refractive Index: 1.55
• Storage Temp.: Keep in dark place,Sealed in dry,Room Temperature
• Solubility: Chloroform (Slightly), Methanol (Slightly, Heated)
• PKA: 2.04±0.10(Predicted)
• CAS DataBase Reference: Methyl 4-amino-2-methoxybenzoate(CAS DataBase Reference)
• NIST Chemistry Reference: Methyl 4-amino-2-methoxybenzoate(27492-84-8)
• EPA Substance Registry System: Methyl 4-amino-2-methoxybenzoate(27492-84-8)

Safety Data

• Hazard Codes: Xn,Xi
• Statements: 22-36/37/38-20/21/22
• Safety Statements: 26-36-36/37/39
• WGK Germany: 2
• HazardClass: IRRITANT
• Hazardous Substances Data: 27492-84-8(Hazardous Substances Data)

Usage

Chemical Properties

Grey Solid

Uses

Different sources of media describe the Uses of 27492-84-8 differently. You can refer to the following data:
1. An intermediate in the synthesis of Metoclopramide.
2. An intermediate in the synthesis of Metoclopramide

InChI:InChI=1/C9H11NO3/c1-12-8-5-6(10)3-4-7(8)9(11)13-2/h3-5H,10H2,1-2H3

Upstream product

• 186581-53-3 diazomethane 
• 2486-80-8 4-amino-2-methoxybenzoic acid 
• 65-49-6 4-Aminosalicylic acid 
• 77-78-1 dimethyl sulfate 
• 89565-76-4 methyl 4-(benzyloxycarbonylamino)-2-methoxybenzoate 
• 75-91-2 tert.-butylhydroperoxide 
• 801992-71-2 C₈H₁₂N₂O 
• 2597-56-0 4-nitro-o-anisic acid 
• 6935-15-5 4‐{[(benzyloxy)carbonyl]amino}‐2‐hydroxybenzoic acid 
• 39106-79-1 methyl 2-methoxy-4-nitrobenzoate 
• 7440-05-3 palladium 
• 67-56-1 methanol 
• 13684-28-1 2-hydroxy-4-nitro-benzoic acid methyl ester 
• 619-19-2 2-hydroxy-4-nitrobenzoic acid 

Downstream Products

• 2486-80-8 4-amino-2-methoxybenzoic acid 
• 4093-29-2 methyl 4-(acetylamino)-o-anisate 
• 3761-48-6 1112JDO 
• 1026304-85-7 2-(4-chloro-phenyl)-N-(4-formyl-3-methoxy-phenyl)-acetamide 
• 1026730-60-8 2-(4-chloro-phenyl)-N-(4-hydroxymethyl-3-methoxy-phenyl)-acetamide 
• 280135-05-9 N-(4-formyl-3-methoxyphenyl)-2-(3-trifluoromethylphenyl)acetamide 
• 280135-04-8 N-(4-hydroxymethyl-3-methoxyphenyl)-2-(3-trifluoromethylphenyl)acetamide 
• 219685-59-3 (4-formyl-3-methoxyphenyl)carbamic acid 9H-fluoren-9-ylmethyl ester 
• 176849-86-8 4-amino-N-(1-ethyl-pyrrolidin-2-ylmethyl)-2-methoxy-benzamide 
• 176849-91-5 4-amino-N-(1-ethyl-pyrrolidin-2-ylmethyl)-5-iodo-2-methoxy-benzamide 
• 211099-27-3 4-(5-Fluoro-2-methyl-benzoylamino)-2-methoxy-benzoyl chloride 
• 86410-33-5 4-Hexadecylamino-2-methoxy-benzoic acid 
• 617246-01-2 4-[3-(2-bromo-4-trifluoromethoxy-phenyl)-ureido]-2-methoxy-benzoic acid methyl ester 

Relevant articles and documents

Copper-catalyzed oxidative methyl-esterification of 5-hydroxymethylfurfural using TBHP as an oxidizing and methylating reagent: A new approach for the synthesis of furan-2,5-dimethylcarboxylate

Catalytic conversion of 5-hydroxymethylfurfural (HMF) into furan-2,5-dimethylcarboxylate (FDMC) is of great significance in the production of polyethylene furanoate (PEF), a renewable biomass-derived polymer that can replace the fossil dependent polyethylene terephthalate (PET). Herein, for the first time, we report the synthesis of FDMC from oxidative methyl-esterification of HMF using tert-butyl hydroperoxide (TBHP) as an oxidizing and methylating reagent catalyzed by mesoporous alumina nanospheres-embedded with CuO nanoparticles (CuO/m-Al2O3). The CuO/m-Al2O3 catalysts with different copper contents were prepared by evaporation-induced self-assembly of a structure-directing agent (Pluronic P-123). The decomposition of P-123 during calcination in air results into the formation of a mesoporous structure with highly dispersed CuO nanoparticles. The as-prepared 6-CuO/m-Al2O3 exhibits excellent catalytic activity towards oxidative methyl-esterification of HMF into FDMC with 92% yield and turnover frequency (TOF) of 0.56 h?1. Furthermore, oxidative methyl-esterification of a range of substrates through SP3 C[sbnd]H bond functionalization has also been demonstrated using the same catalyst.

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QUINAZOLINE-BASED KINASE INHIBITORS

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