2766-31-6

Basic information

• Product Name: Glycine, N-[1-[(phenylmethoxy)carbonyl]-L-prolyl]-, ethyl ester
• CAS NO: 2766-31-6
• Molecular Formula: C17H22N2O5
• Molecular Weight: 334.372
• Mol File: 2766-31-6.mol
• Article Data: 14

Chemical Properties

• CAS DataBase Reference: Glycine, N-[1-[(phenylmethoxy)carbonyl]-L-prolyl]-, ethyl ester(CAS DataBase Reference)
• NIST Chemistry Reference: Glycine, N-[1-[(phenylmethoxy)carbonyl]-L-prolyl]-, ethyl ester(2766-31-6)
• EPA Substance Registry System: Glycine, N-[1-[(phenylmethoxy)carbonyl]-L-prolyl]-, ethyl ester(2766-31-6)

Safety Data

• Hazardous Substances Data: 2766-31-6(Hazardous Substances Data)

Upstream product

• 109-02-4 4-methyl-morpholine 
• 623-33-6 glycine ethyl ester hydrochloride 
• 1148-11-4 N-Benzyloxycarbonyl-L-proline 
• 543-27-1 isobutyl chloroformate 
• 6404-31-5 Z-D-proline 
• 75509-45-4 N-(2-oxido-1,2,3-benzodioxaphosphol-2-yl) glycine ethyl ester 
• 1148-11-4 N-Benzoyloxycarbonyl-L-prolin 
• 1059596-61-0 N-Cbz-L-proline p-tolylthiol ester 
• 147-85-3 L-proline 
• 501-53-1 benzyl chloroformate 
• 26607-48-7 1-benzyl hydrogen (S)-pyrrolidine-1,2-dicarboxylate, compound with dicyclohexylamine (1:1) 
• 459-73-4 GlyOEt*HCl 
• 927-80-0 1-ethoxyacetylene 
• 541-41-3 chloroformic acid ethyl ester 

Downstream Products

• 3705-27-9 (S)-hexahydropyrrolo[1,2-a]pyrazine-1,4-dione 
• 23828-27-5 N-[N-(1-benzyloxycarbonyl-L-prolyl)-glycyl]-L-phenylalanine-methyl ester 
• 23828-28-6 Z-Pro-Gly-Tyr 
• 23828-29-7 N-(N-L-prolyl-glycyl)-L-phenylalanine 
• 76523-90-5 Z-Arg(NO₂)-Pro-Pro-Gly-Phe-Ser-Pro-5-Ava-OBzl 
• 135112-37-7 Z-Pro-Gly-Phe-5-Ava-Phe-Arg(NO₂)-OMe 
• 76523-63-2 H-Arg-Pro-Pro-Gly-Phe-Ser-Pro-5-Ava-OH 
• 6513-19-5 Z-Arg(NO₂)-Pro-Pro-Gly-OEt 
• 2533-51-9 Z-Arg(NO₂)-Pro-Pro-Gly-OH 
• 76523-70-1 Z-5-Ava-Pro-Gly-OEt 
• 76523-71-2 Z-5-Ava-Pro-Gly-OH 
• 135112-32-2 Z-Arg(NO₂)-Pro-Pro-Gly-5-Ava-Pro-Phe-Arg(NO₂)-OBzl 
• 135112-39-9 H-Arg-Pro-Pro-Gly-Phe-5-Ava-Phe-Arg-OH 
• 135112-38-8 Z-Arg(NO₂)-Pro-Pro-Gly-Phe-5-Ava-Phe-Arg(NO₂)-OMe 

Relevant articles and documents

Tandem deprotection/coupling for peptide synthesis in water at room temperature

A tandem deprotection/coupling sequence is reported for solution-phase peptide synthesis in water under micellar catalysis conditions using the designer surfactant TPGS-750-M. Cbz deprotection followed by peptide coupling in the presence of COMU and 2,6-lutidine afforded polypeptides containing up to 10 amino acid residues. A broad scope characterizes this new technology. No epimerization has been detected. The associated E Factors, as a measure of "greenness" and known to be extremely high for peptide couplings, have been reduced to less than 10 due to the step-economy and minimal amounts of organic solvent needed for product extraction.

An efficient protocol for the amidation of carboxylic acids promoted by trimethyl phosphite and iodine

A practical, one-pot protocol is described for the conversion of carboxylic acids into amides through carboxyl activation by the reagent combination of trimethyl phosphite and iodine. This method integrates several advantages: (1) it allows amines to be chemoselectively acylated with excellent results in the presence of sulfur and oxygen nucleophiles; (2) the method shows wide generality in respect of solvent, base, and substrate; (3) the reagents used are widely available and much less expensive than common coupling reagents, and (4) the process is remarkably convenient, permitting extraction, recrystallization, and column chromatography as optional work-up procedures. The chemoselectivity and generality of the method, the low cost, and wide availability of reagents combined with the ease of use make it a very favorable process.

A new method for the synthesis of carboxamides and peptides using 1,1′-carbonyldioxydi[2(1H)-pyridone] (CDOP) in the absence of basic promoters

Various carboxamides or peptides are synthesized from the corresponding carboxylic acids and amines or α-amino acids using 1,1′-carbonyldioxydi[2(1H)-pyridone]. The reaction proceeds in the absence of basic promoters such as triethylamine or 4-(dimethylamino)pyridine, therefore, the undesired racemization does not occur at all in the segment coupling producing Z-Gly-Phe-Val-OMe and Z-Phe-Val-Ala-OMe.