27808-16-8

Basic information

• Product Name: 4-METHYL-1H-1,2,3-TRIAZOLE
• Synonyms: 4-METHYL-1H-1,2,3-TRIAZOLE;4-Methyl-1H-1,2,3-triazole hydrochloride;5-Methyl-1H-1,2,3-triazole;4-Methyl-1,2,3-triazole
• CAS NO: 27808-16-8
• Molecular Formula: C₃H₅N₃
• Molecular Weight: 83.0919
• Mol File: 27808-16-8.mol
• Article Data: 6

Chemical Properties

• Melting Point: 35-36 °C
• Boiling Point: 209.61°C at 760 mmHg
• Flash Point: 98.741°C
• Appearance: /
• Density: 1.179g/cm³
• Vapor Pressure: 0.291mmHg at 25°C
• Refractive Index: 1.528
• Storage Temp.: Inert atmosphere,Room Temperature
• PKA: 9.18±0.70(Predicted)
• CAS DataBase Reference: 4-METHYL-1H-1,2,3-TRIAZOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 4-METHYL-1H-1,2,3-TRIAZOLE(27808-16-8)
• EPA Substance Registry System: 4-METHYL-1H-1,2,3-TRIAZOLE(27808-16-8)

Safety Data

• Hazardous Substances Data: 27808-16-8(Hazardous Substances Data)

Usage

General Description

4-Methyl-1H-1,2,3-triazole is a chemical compound that falls under the category of triazoles, which are a class of organic compounds. These triazoles are essentially heterocyclic compounds with a five-membered ring containing two carbon atoms and three nitrogen atoms. This particular compound, 4-methyl-1H-1,2,3-triazole, has an additional methyl group attached, making it a derivative of 1,2,3-triazole. It is commonly used in organic synthesis, pharmaceuticals, and agrochemicals due to its various industrial functionalities. As a compound, it is typically categorized as a stable, somewhat flammable material that requires careful handling due to its corrosive properties. It also possesses high reactivity, making it appropriate for reactions involved in various synthesis processes.

InChI:InChI=1/C3H5N3/c1-3-2-4-6-5-3/h2H,1H3,(H,4,5,6)

Upstream product

• 89166-02-9 5-methyl-1H-[1,2,3]triazole-4-carboxylic acid 
• 56020-04-3 N'-(1,1-dimethoxypropan-2-ylidene)-4-methylbenzenesulfonohydrazide 
• 1439-36-7 1-triphenylphosphoranylidene-2-propanone 
• 70380-30-2 1‐benzyl‐4‐(bromomethyl)‐1H‐1,2,3‐triazole 
• 74-99-7 prop-1-yne 

Downstream Products

• 27200-07-3 4-methyl-2-(4-nitrophenyl)-2H-1,2,3-triazole 
• 591232-22-3 1-(2-fluoro-4-nitro-phenyl)-4-methyl-[1,2,3]-triazole 
• 16681-70-2 1H-1,2,3-triazole-4-carboxylic acid 

Relevant articles and documents

A Scalable Metal-, Azide-, and Halogen-Free Method for the Preparation of Triazoles

A scalable metal-, azide-, and halogen-free method for the synthesis of substituted 1,2,3-triazoles has been developed. The reaction proceeds through a 3-component coupling of α-ketoacetals, tosyl hydrazide, and a primary amine. The reaction shows outstanding functional-group tolerance with respect to both the α-ketoacetal and amine coupling partners, providing access to 4-, 1,4-, 1,5-, and 1,4,5-substituted triazoles in excellent yield. This robust method results in densely functionalised 1,2,3-triazoles that remain challenging to prepare by azide–alkyne cycloaddition (AAC, CuAAC, RuAAC) methods and can be scaled in either batch or flow reactors. Methods for the chemoselective reaction of either aliphatic amines or anilines are also described, revealing some of the potential of this novel and highly versatile transformation.

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Described herein are compounds of Formula I, methods of making such compounds, pharmaceutical compositions and medicaments containing such compounds, and methods of using such compounds to treat or prevent diseases or conditions in need of inhibition of heparan sulfate biosynthesis.

Composition and antiviral activity of substituted azaindoleoxoacetic piperazine derivatives

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