27808-53-3 Usage
Description
[1,2,5]Oxadiazolo[3,4-b]pyridine, 3-oxide is a heterocyclic chemical compound with the molecular formula C6H3N3O2. It features an oxadiazole and pyridine ring system, which contribute to its unique electronic and photophysical properties. [1,2,5]Oxadiazolo[3,4-b]pyridine, 3-oxide is widely recognized for its potential applications in various fields, including pharmaceutical drug development, agrochemicals, and materials science.
Uses
Used in Pharmaceutical Drug Development:
[1,2,5]Oxadiazolo[3,4-b]pyridine, 3-oxide is used as a building block in the pharmaceutical industry for the synthesis of novel drugs. Its unique structure and properties make it a valuable component in the development of new therapeutic agents.
Used in Agrochemicals:
In the agrochemical industry, [1,2,5]Oxadiazolo[3,4-b]pyridine, 3-oxide is used as a key component in the creation of innovative agrochemical products. Its incorporation into these products can enhance their effectiveness and contribute to more sustainable agricultural practices.
Used in Materials Science:
[1,2,5]Oxadiazolo[3,4-b]pyridine, 3-oxide is utilized as a building block in materials science for the development of new materials with unique properties. Its electronic and photophysical characteristics make it a promising candidate for applications in various technological advancements.
Used in Antimicrobial Applications:
[1,2,5]Oxadiazolo[3,4-b]pyridine, 3-oxide has been studied for its potential antimicrobial properties, making it a candidate for use in the development of new antimicrobial agents to combat drug-resistant bacteria and other pathogens.
Used in Anticancer Applications:
[1,2,5]Oxadiazolo[3,4-b]pyridine, 3-oxide has also been investigated for its potential anticancer properties, with research focusing on its ability to target and inhibit the growth of cancer cells. [1,2,5]Oxadiazolo[3,4-b]pyridine, 3-oxide may be used as a starting point for the development of new anticancer drugs in the future.
Check Digit Verification of cas no
The CAS Registry Mumber 27808-53-3 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,7,8,0 and 8 respectively; the second part has 2 digits, 5 and 3 respectively.
Calculate Digit Verification of CAS Registry Number 27808-53:
(7*2)+(6*7)+(5*8)+(4*0)+(3*8)+(2*5)+(1*3)=133
133 % 10 = 3
So 27808-53-3 is a valid CAS Registry Number.
27808-53-3Relevant articles and documents
Furoxan rearrangement of some pyridofuroxan derivatives studied by 1H, 13C, 14N, 15N and 17O NMR spectroscopy
Cmoch,Kamienski,Kamienska-Trela,Stefaniak,Webb
, p. 480 - 488 (2007/10/03)
Pyridofuroxan ([1,2,5]oxodiazolo[3,4-b]pyridine 1-oxide) undergoes isomerization between the N1-oxide and N3-oxide forms which can be observed by the 1H, 13C and 15N NMR spectroscopy but not by 14N and 17O NMR at ambient and low temperatures. The rearrangement becomes slower at low temperatures and at 233 K 1H NMR signals for the two structures become observable. 1H, 13C and 15N chemical shifts and 1H-1H, 13C-1H and 13C-13C coupling constants are used to characterize both forms in the equilibrium mixture. From the 1H NMR integrals at 233 K equilibrium constants are calculated. Protonation studies using trifluoroacetic acid as a solvent showed the favoured site of protonation to be the pyridine N4 nitrogen atom. DFT shielding calculations are reported for the 13C, 15N and 17O nuclei which support the assignments given. From the point of view of structural changes, 1JCC data for 8-nitrotetrazolo[1,5-a]pyridine and o-nitroaminopyridine as precursors of the pyridofuroxans are given for comparison purposes. X-ray diffraction data on 5-methoxypyridofuroxan support the structural results obtained from the NMR investigations. Copyright
Pyrolysis of Aryl Azides. VI Identification of Neighbouring Group Effects in Pyrolysis of Azidopyridines and Azidoquinolines
Dyall, Leonard K.,Wah, Wong Ming
, p. 1045 - 1059 (2007/10/02)
Although there are literature reports of anomalous behaviour on pyrolysis of ortho-nitroazidopyridines and ortho-nitroazidoquinolines, we find that these compounds cyclize to the expected furazan 1-oxides in near-quantitative yields, and with a high degree of neighbouring group participation by the nitro group.Kinetic studies in decalin solution reveal the following rate enhancements by the ortho-nitro group: 3-azido-2-nitropyridine, 466 at least; 4-azido-3-nitropyridine, 5400; 4-azido-3,5-dinitropyridine, 640; 4-azido-3-nitroquinoline, 82.4; 5-azido-6-nitroquinoline,27.6; 2-nitro-1-azidonaphthalene, 12.7.The unstable furazan oxide, oxadiazolopyridine 1-oxide, has now been characterized. Oxadiazolopyridine 1-oxide decomposed in decalin at 145 deg to give products indicative of a nitrene intermediate.
