Welcome to LookChem.com Sign In|Join Free

Cas Database

2781-29-5

2781-29-5

Identification

  • Product Name:3,4-Dimethyl-1,5-hexadiene-3,4-diol

  • CAS Number: 2781-29-5

  • EINECS:

  • Molecular Weight:142.198

  • Molecular Formula: C8H14O2

  • HS Code:2905399090

  • Mol File:2781-29-5.mol

Synonyms:3,4-Dimethyl-1,5-hexadiene-3,4-diol

Post Buying Request Now
Entrust LookChem procurement to find high-quality suppliers faster

Safety information and MSDS view more

  • Signal Word:no data available

  • Hazard Statement:no data available

  • First-aid measures: General adviceConsult a physician. Show this safety data sheet to the doctor in attendance.If inhaled If breathed in, move person into fresh air. If not breathing, give artificial respiration. Consult a physician. In case of skin contact Wash off with soap and plenty of water. Consult a physician. In case of eye contact Rinse thoroughly with plenty of water for at least 15 minutes and consult a physician. If swallowed Never give anything by mouth to an unconscious person. Rinse mouth with water. Consult a physician.

  • Fire-fighting measures: Suitable extinguishing media Use water spray, alcohol-resistant foam, dry chemical or carbon dioxide. Wear self-contained breathing apparatus for firefighting if necessary.

  • Accidental release measures: Use personal protective equipment. Avoid dust formation. Avoid breathing vapours, mist or gas. Ensure adequate ventilation. Evacuate personnel to safe areas. Avoid breathing dust. For personal protection see section 8. Prevent further leakage or spillage if safe to do so. Do not let product enter drains. Discharge into the environment must be avoided. Pick up and arrange disposal. Sweep up and shovel. Keep in suitable, closed containers for disposal.

  • Handling and storage: Avoid contact with skin and eyes. Avoid formation of dust and aerosols. Avoid exposure - obtain special instructions before use.Provide appropriate exhaust ventilation at places where dust is formed. For precautions see section 2.2. Store in cool place. Keep container tightly closed in a dry and well-ventilated place.

  • Exposure controls/personal protection:Occupational Exposure limit valuesBiological limit values Handle in accordance with good industrial hygiene and safety practice. Wash hands before breaks and at the end of workday. Eye/face protection Safety glasses with side-shields conforming to EN166. Use equipment for eye protection tested and approved under appropriate government standards such as NIOSH (US) or EN 166(EU). Skin protection Wear impervious clothing. The type of protective equipment must be selected according to the concentration and amount of the dangerous substance at the specific workplace. Handle with gloves. Gloves must be inspected prior to use. Use proper glove removal technique(without touching glove's outer surface) to avoid skin contact with this product. Dispose of contaminated gloves after use in accordance with applicable laws and good laboratory practices. Wash and dry hands. The selected protective gloves have to satisfy the specifications of EU Directive 89/686/EEC and the standard EN 374 derived from it. Respiratory protection Wear dust mask when handling large quantities. Thermal hazards

Supplier and reference price

  • Manufacture/Brand
  • Product Description
  • Packaging
  • Price
  • Delivery
  • Purchase

Relevant articles and documentsAll total 2 Articles be found

Revisiting Bromohexitols as a Novel Class of Microenvironment-Activated Prodrugs for Cancer Therapy

Johansson, Henrik,Hussain, Omar,Allison, Simon J.,Robinson, Tony V.,Phillips, Roger M.,Sejer Pedersen, Daniel

supporting information, p. 228 - 235 (2019/12/11)

Bromohexitols represent a potent class of DNA-alkylating carbohydrate chemotherapeutics that has been largely ignored over the last decades due to safety concerns. The limited structure?activity relationship data available reveals significant changes in cytotoxicity with even subtle changes in stereochemistry. However, no attempts have been made to improve the therapeutic window by rational drug design or by using a prodrug approach to exploit differences between tumour physiology and healthy tissue, such as acidic extracellular pH and hypoxia. Herein, we report the photochemical synthesis of highly substituted endoperoxides as key precursors for dibromohexitol derivatives and investigate their use as microenvironment-activated prodrugs for targeting cancer cells. One endoperoxide was identified to have a marked increased activity under hypoxic and low pH conditions, indicating that endoperoxides may serve as microenvironment-activated prodrugs.

REDUCTIVE COUPLING OF α,β-ENONES I : REDUCTION OF METHYL-VINYL KETONE AND MESITYL OXIDE.

Pons, Jean-Marc,Zahra, Jean-Pierre,Santelli, Maurice

, p. 3965 - 3968 (2007/10/02)

Reductive coupling of methyl-vinyl ketone with TiCl4-Mg gives pinacol 1 (25percent).According to the reducing agents, mesityl oxide yields 2,4,5,7-tetramethyl-octa-2,4,6-triene 3 (with 4TiCl3-LiAlH4), triene 3 or 2,4,5,7-tetramethyl-octa-2,6-dien-4,5-diol 5 (with TiCl4-Mg), pinacol 5 (with VCl3-Mg), and 2-acetyl-1,3,3,4,4-pentamethyl-cyclopentene 7 (with CrCl3-Mg or FeCl3-Mg or ZrCl4-Mg) as major products.

Process route upstream and downstream products

Process route

vinyl magnesium bromide
1826-67-1

vinyl magnesium bromide

dimethylglyoxal
431-03-8

dimethylglyoxal

3,4-Dimethyl-hexadien-(1,5)-diol-(3,4)
2781-29-5

3,4-Dimethyl-hexadien-(1,5)-diol-(3,4)

Conditions
Conditions Yield
In tetrahydrofuran; at -78 ℃; for 1.66667h;
38%
methyl vinyl ketone
78-94-4,25038-87-3

methyl vinyl ketone

m-pinacol
80885-60-5

m-pinacol

Conditions
Conditions Yield
With titanium tetrachloride; magnesium; tert-butyl alcohol; In tetrahydrofuran; Yield given. Yields of byproduct given;
vinylmagnesium chloride
3536-96-7

vinylmagnesium chloride

dimethylglyoxal
431-03-8

dimethylglyoxal

3,4-Dimethyl-hexadien-(1,5)-diol-(3,4)
2781-29-5

3,4-Dimethyl-hexadien-(1,5)-diol-(3,4)

Conditions
Conditions Yield
In tetrahydrofuran; diethyl ether;
methyl vinyl ketone
78-94-4,25038-87-3

methyl vinyl ketone

3,4-Dimethyl-hexadien-(1,5)-diol-(3,4)
2781-29-5

3,4-Dimethyl-hexadien-(1,5)-diol-(3,4)

Conditions
Conditions Yield
With acetic acid; zinc;
3,4-Dimethyl-hexadien-(1,5)-diol-(3,4)
2781-29-5

3,4-Dimethyl-hexadien-(1,5)-diol-(3,4)

Conditions
Conditions Yield
3-Chlorbutan-2-on, Na-Amalgam;
Diketon, Grignard;
a.d. Gemisch v. Acrolein u. Methyl-vinyl-keton - red. Kondensation - (neben 3,4-Dihydroxy-hexadien-(1,5) <50percent>, 3,4-Dihydroxy-3-methyl-hexadien-(1,5) <30percent>);
(yield)5percent;
entspr. Carbonylverb., entspr. Katalysator, H+;
Methylvinylketon ;
Cyclohexanol, Acetanhydrid, in Ggw. v. Dimethylsulfoxid;
3,4-Dimethyl-hexadien-(1,5)-diol-(3,4)
2781-29-5

3,4-Dimethyl-hexadien-(1,5)-diol-(3,4)

1-(2-methylcyclopent-1-enyl)ethanone
3168-90-9

1-(2-methylcyclopent-1-enyl)ethanone

Conditions
Conditions Yield
at 240 ℃;

Global suppliers and manufacturers

Global( 0) Suppliers
  • Company Name
  • Business Type
  • Contact Tel
  • Emails
  • Main Products
  • Country
close
Post a RFQ

Enter 15 to 2000 letters.Word count: 0 letters

Attach files(File Format: Jpeg, Jpg, Gif, Png, PDF, PPT, Zip, Rar,Word or Excel Maximum File Size: 3MB)

1

What can I do for you?
Get Best Price

Get Best Price for 2781-29-5
Post Buying Request Now
close
Remarks: The blank with*must be completed