28116-56-5

Basic information

• Product Name: 4-[2-hydroxy-2-(5-hydroxy-3,5-dimethyl-2-oxocyclohexyl)ethyl]piperidine-2,6-dione
• CAS NO: 28116-56-5
• Molecular Formula: C₁₅H₂₃NO₅
• Molecular Weight: 297.3468
• Mol File: 28116-56-5.mol
• Article Data: 3

Chemical Properties

• Boiling Point: 535.1°C at 760 mmHg
• Flash Point: 277.4°C
• Density: 1.223g/cm³
• Vapor Pressure: 1.1E-13mmHg at 25°C
• Refractive Index: 1.522
• CAS DataBase Reference: 4-[2-hydroxy-2-(5-hydroxy-3,5-dimethyl-2-oxocyclohexyl)ethyl]piperidine-2,6-dione(CAS DataBase Reference)
• NIST Chemistry Reference: 4-[2-hydroxy-2-(5-hydroxy-3,5-dimethyl-2-oxocyclohexyl)ethyl]piperidine-2,6-dione(28116-56-5)
• EPA Substance Registry System: 4-[2-hydroxy-2-(5-hydroxy-3,5-dimethyl-2-oxocyclohexyl)ethyl]piperidine-2,6-dione(28116-56-5)

Safety Data

• Hazardous Substances Data: 28116-56-5(Hazardous Substances Data)

Upstream product

• 1001-75-8 4-methyl-4-pentenoic acid 
• 1149347-46-5 3-[(dodecylthio-carbonyl)-methyl]-glutarimide 
• 131077-79-7 trans-2,4-dimethyl-4-trimethylsiloxy-1-cyclohexanone 
• 66-81-9 Cycloheximide 
• 60739-53-9 4-(tetrahydro-2H-pyran-2-yloxy)cyclohexanone 
• 131077-81-1 4-[2-((3R,5S)-3,5-Dimethyl-2-oxo-5-trimethylsilanyloxy-cyclohexyl)-2-hydroxy-ethyl]-piperidine-2,6-dione 
• 131077-81-1 4-[2-((3S,5S)-3,5-Dimethyl-2-oxo-5-trimethylsilanyloxy-cyclohexyl)-2-hydroxy-ethyl]-piperidine-2,6-dione 
• 89794-52-5 1-methyl-1,4-cyclohexanediol 
• 131077-79-7 cis-2,4-dimethyl-4-trimethylsiloxy-1-cyclohexanone 
• 13482-22-9 4-hydroxycyclohexanone 
• 17429-02-6 4-hydroxy-4-methylcyclohexanone 

Downstream Products

• 4348-89-4 4-(2-hydroxy-3,5-dimethyl-phenethyl)-piperidine-2,6-dione 
• 131057-04-0 Acetic acid (1R,3S,5S)-3-[(R)-2-(2,6-dioxo-piperidin-4-yl)-1-triethylsilanyloxy-ethyl]-1,5-dimethyl-4-oxo-cyclohexyl ester 

Relevant articles and documents

Versatile Synthetic Route to Cycloheximide and Analogues That Potently Inhibit Translation Elongation

Cycloheximide (CHX) is an inhibitor of eukaryotic translation elongation that has played an essential role in the study of protein synthesis. Despite its ubiquity, few studies have been directed towards accessing synthetic CHX derivatives, even though such efforts may lead to protein synthesis inhibitors with improved or alternate properties. Described here is the total synthesis of CHX and analogues, and the establishment of structure–activity relationships (SAR) responsible for translation inhibition. The SAR studies aided the design of more potent compounds, one of which irreversibly blocks ribosomal elongation, preserves polysome profiles, and may be a broadly useful tool for investigating protein synthesis.

Syntheses and biological activities of (+/-)-streptovitacin A and E-73.

(+/-)-Streptovitacin A (1) and its stereoisomers were synthesized by an aldol reaction of (+/-)-2,4-dimethyl-4-trimethylsiloxy-1-cyclohexanones (4b and 9) with 4-(2-oxoethyl)-2,6-piperidinedione (5). E-72 (2) was derived from synthetic 1. (+/-)-1 showed m