281192-91-4

Basic information

• Product Name: 1-METHYL-3-BROMO-7-AZAINDOLE
• Synonyms: 1H-PYRROLO[2,3-B]PYRIDINE,3-BROMO-1-METHYL-;1-METHYL-3-BROMO-7-AZAINDOLE;3-bromo-1-methyl-1H-pyrrolo[2,3-b]pyridine;3-BroMo-1-Methylpyrrolo[2,3-b]pyridine;3-Bromo-1-methyl-7-azaindole
• CAS NO: 281192-91-4
• Molecular Formula: C₈H₇BrN₂
• Molecular Weight: 211.06
• Mol File: 281192-91-4.mol

Chemical Properties

• Boiling Point: 315.3±22.0 °C(Predicted)
• Flash Point: >110℃
• Appearance: /
• Density: 1.505 g/mL at 25 °C
• Refractive Index: n20/D1.629
• Storage Temp.: Sealed in dry,Store in freezer, under -20°C
• PKA: 4.10±0.30(Predicted)
• CAS DataBase Reference: 1-METHYL-3-BROMO-7-AZAINDOLE(CAS DataBase Reference)
• NIST Chemistry Reference: 1-METHYL-3-BROMO-7-AZAINDOLE(281192-91-4)
• EPA Substance Registry System: 1-METHYL-3-BROMO-7-AZAINDOLE(281192-91-4)

Safety Data

• Hazard Codes: Xn
• Statements: 22-37/38-41
• Safety Statements: 26-39
• WGK Germany: 3
• Hazardous Substances Data: 281192-91-4(Hazardous Substances Data)

Usage

Uses

Used in Pharmaceutical Research and Development:
1-METHYL-3-BROMO-7-AZAINDOLE is used as a building block in organic synthesis for the creation of potential drug candidates. Its versatility as an intermediate allows for the development of various biologically active molecules, contributing to the advancement of novel drugs and therapeutic agents.
Used in Medicinal Chemistry:
1-METHYL-3-BROMO-7-AZAINDOLE is utilized as a versatile intermediate in medicinal chemistry, enabling the synthesis of a wide range of biologically active compounds. Its unique structure facilitates the exploration of new chemical entities with potential therapeutic applications, thereby enhancing the discovery of innovative treatments for various diseases and conditions.

Upstream product

• 27257-15-4 1-methyl-1H-pyrrolo[2,3-b]pyridine 
• 271-63-6 7-Azaindole 
• 74420-15-8 3-bromo-1H-pyrrolo[2,3-b]pyridine 
• 4637-24-5 N,N-dimethyl-formamide dimethyl acetal 

Downstream Products

• 281192-94-7 N-Methyl-7-azaisatin 

Relevant articles and documents

Selective methylation of NH-containing heterocycles and sulfonamides using n, N -dimethylformamide dimethylacetal based on calculated pKa Measurements

The use of N,N-dimethylformamide dimethylacetal (DMF-DMA) as a suitable methylating agent for the methylation of NH-containing groups and heterocycles has been investigated. Use of ReactArray and calculated pKa measurements have allowed additional helpful information to be collated to determine optimum reaction conditions for a variety of substrates.

A facile synthesis of 1-alkyl-7-azaisatins

1-Alkyl-7-azaisatins are synthesized from the reaction of 1-alkyl-7- azaindoles with bromine in dichloromethane and subsequent oxidation with N- bromosuccinimide - dimethyl sulfoxide reagent. 1-Alkyl-7-azaindoles are readily available in high yields from