28122-82-9

Basic information

• Product Name: S-phenyl 4-chlorobenzenecarbothioate
• CAS NO: 28122-82-9
• Molecular Formula: C₁₃H₉ClOS
• Molecular Weight: 248.728
• Mol File: 28122-82-9.mol
• Article Data: 28

Chemical Properties

• Boiling Point: 357.8°C at 760 mmHg
• Flash Point: 170.2°C
• Density: 1.31g/cm³
• Vapor Pressure: 2.66E-05mmHg at 25°C
• Refractive Index: 1.65
• CAS DataBase Reference: S-phenyl 4-chlorobenzenecarbothioate(CAS DataBase Reference)
• NIST Chemistry Reference: S-phenyl 4-chlorobenzenecarbothioate(28122-82-9)
• EPA Substance Registry System: S-phenyl 4-chlorobenzenecarbothioate(28122-82-9)

Safety Data

• Hazardous Substances Data: 28122-82-9(Hazardous Substances Data)

Upstream product

• 122-01-0 4-chloro-benzoyl chloride 
• 108-98-5 thiophenol 
• 201230-82-2 carbon monoxide 
• 74-11-3 para-chlorobenzoic acid 
• 7099-88-9 4-chlorophenylglyoxylic acid 
• 5285-87-0 phenyl thiocyanate 
• 930-69-8 sodium thiophenolate 
• 637-87-6 1-Chloro-4-iodobenzene 
• 1012-56-2 (Et)3tin(phenylthiolate) 
• 536-40-3 4-chlorobenzoic acid hydrazide 
• 882-33-7 diphenyldisulfane 
• 591-50-4 iodobenzene 
• 104-88-1 4-chlorobenzaldehyde 
• 106-39-8 bromochlorobenzene 

Downstream Products

• 134-85-0 4-chlorobenzophenone 
• 35256-82-7 (p-chlorophenyl)(m-methylphenyl)methanone 
• 62810-38-2 4-chlorophenyl 3-nitrophenyl ketone 
• 53451-90-4 phenyl 4-trifluoromethylphenyl sulfide 
• 1889-71-0 4'-chloro-2-phenylacetophenone 
• 4018-82-0 4-chloro-N-(4-methoxyphenyl)benzamide 
• 39193-06-1 4,4'-dichlorobenzanilide 
• 20849-33-6 phenyl p-chlorobenzenedithiocarboxylate 
• 6833-15-4 4-chlorobenzanilide 
• 13343-26-5 phenyl p-chlorophenyl sulfide 
• 882-33-7 diphenyldisulfane 
• 98-11-3 benzenesulfonic acid 
• 74-11-3 para-chlorobenzoic acid 
• 2447-95-2 4-chloro-N-(4-tolyl)benzamide 

Relevant articles and documents

Cu-Catalyzed Oxidative Thioesterification of Aroylhydrazides with Disulfides

An alternative thioesterification reaction via copper-catalyzed oxidative coupling of readily available aroylhydrazides with disulfides is developed, in which oxidative expulsion of N2 overcomes the activation barrier between the carboxylic acid derivativ

Pd-Catalyzed Double-Decarbonylative Aryl Sulfide Synthesis through Aryl Exchange between Amides and Thioesters

We report the palladium-catalyzed double-decarbonylative synthesis of aryl thioethers by an aryl exchange reaction between amides and thioesters. In this method, amides serve as aryl donors and thioesters are sulfide donors, enabling the synthesis of valuable aryl sulfides. The use of Pd/Xantphos without any additives has been identified as the catalytic system promoting the aryl exchange by C(O)-N/C(O)-S cleavages. The method is amenable to a wide variety of amides and sulfides.

Fukuyama Cross-Coupling Approach to Isoprekinamycin: Discovery of the Highly Active and Bench-Stable Palladium Precatalyst POxAP

An efficient and user-friendly palladium(II) precatalyst, POxAP (post-oxidative-addition precatalyst), was identified for use in Fukuyama cross-coupling reactions. Suitable for storage under air, the POxAP precatalyst allowed reaction between thioesters and organozinc reagents with turnover numbers of ～90000. A series of 23 ketones were obtained with yields ranging from 53 to 99%. As proof of efficacy, an alternative approach was developed for the synthesis of a key precursor of the natural product isoprekinamycin.