28144-70-9

Basic information

• Product Name: Benzenecarboximidic acid, 2-amino- (9CI)
• Synonyms: Benzenecarboximidic acid, 2-amino- (9CI)
• CAS NO: 28144-70-9
• Molecular Formula: C₇H₈N₂O
• Molecular Weight: 136.15122
• Product Categories: AMIDE
• Mol File: 28144-70-9.mol
• Article Data: 111

Chemical Properties

• Appearance: /
• CAS DataBase Reference: Benzenecarboximidic acid, 2-amino- (9CI)(CAS DataBase Reference)
• NIST Chemistry Reference: Benzenecarboximidic acid, 2-amino- (9CI)(28144-70-9)
• EPA Substance Registry System: Benzenecarboximidic acid, 2-amino- (9CI)(28144-70-9)

Safety Data

• Hazardous Substances Data: 28144-70-9(Hazardous Substances Data)

Usage

General Description

Benzenecarboximidic acid, 2-amino- (9CI) is a chemical compound with the molecular formula C7H7N3O2. It is also known as 2-aminobenzimidamide and is classified as an aromatic amine. Benzenecarboximidic acid, 2-amino- (9CI) is a white powder at room temperature and is soluble in water. It is commonly used in the pharmaceutical industry as an intermediate in the synthesis of various drugs and organic compounds. Additionally, it has been studied for its potential use in the treatment of cancer. Benzenecarboximidic acid, 2-amino- (9CI) is also a key building block in the production of dyes, pigments, and other industrial chemicals.

Upstream product

• 118-48-9 isatoic anhydride 
• 574-17-4 1-acetyl-1H-indole-2,3-dione 
• 91-56-5 indole-2,3-dione 
• 612-24-8 o-nitrobenzonitrile 
• 33330-89-1 1-(2'-carbamoylphenyl)-3,3-dimethyltriazene 
• 118-92-3 anthranilic acid 
• 1885-29-6 anthranilic acid nitrile 
• 7664-93-9 sulfuric acid 
• 7664-41-7 ammonia 
• 64-17-5 ethanol 
• 141-78-6 ethyl acetate 
• 7647-01-0 hydrogenchloride 
• 64-19-7 acetic acid 
• 67-56-1 methanol 

Downstream Products

• 13220-57-0 tryptanthrine 
• 18257-55-1 N-(2-carbamoylphenyl)phthalimide 
• 41217-30-5 ethyl (2-carbamoylphenyl)carbamate 
• 33809-77-7 2-acetamidobenzamide 
• 4765-49-5 N-(2-chloro-benzoyl)-anthranilic acid amide 
• 35717-70-5 N-salicyliden-anthranilic acid amide 
• 18543-22-1 2-benzoylaminobenzamide 
• 74375-44-3 o-ethylaminobenzamide 
• 16285-26-0 2-(furan-2-yl)-2,3-dihydroquinazolin-4(1H)-one 
• 13324-83-9 2-(thiophen-2-yl)-2,3-dihydroquinazoline-4(1H)-one 
• 59349-88-1 2-amino-N-(di-morpholin-4-yl-phosphinoyl)-benzamide 
• 54166-94-8 2-carbamoyloxanilic acid ethyl ester 
• 88267-61-2 2-(2-hydroxyethylamino)benzamide 
• 56043-04-0 2-mercapto-3-phenyl-2-thioxo-2,3-dihydro-1H-2λ⁵-benzo[1,3,2]diazaphosphinine-4-thione; pyridine salt 

Relevant articles and documents

Synthesis of new quinazoline-containing hydroxamic acids as potential HDAC/VEGFR inhibitors. Unusual rearrangements with pyrrolidone ring opening and dehydration of 3-N-hydroxyquinazoline fragment containing tetracycles

Synthesis pathways were developed and new hydroxamic acids were obtained as potential inhibitors of HDAC/VEGFR2, including tetracycles containing quinazolinone fragment as a “cap”. Further biological testing of the obtained compounds will give an opportunity to estimate the real prospects of the chosen research direction.

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QUINAZOLINE COMPOUNDS AND THE USE THEREOF IN THE TREATMENT OF CANCER

The present disclosure relates generally to a class of quinazoline compounds, compositions containing the same and the therapeutic use of the compounds in the treatment of cancer.

Aerobic oxidation of primary amines to amides catalyzed by an annulated mesoionic carbene (MIC) stabilized Ru complex

Catalytic aerobic oxidation of primary amines to the amides, using the precatalyst [Ru(COD)(L1)Br2] (1) bearing an annulated π-conjugated imidazo[1,2-a][1,8]naphthyridine-based mesoionic carbene ligand L1, is disclosed. This catalytic protocol is distinguished by its high activity and selectivity, wide substrate scope and modest reaction conditions. A variety of primary amines, RCH2NH2 (R = aliphatic, aromatic and heteroaromatic), are converted to the corresponding amides using ambient air as an oxidant in the presence of a sub-stoichiometric amount of KOtBu in tBuOH. A set of control experiments, Hammett relationships, kinetic studies and DFT calculations are undertaken to divulge mechanistic details of the amine oxidation using 1. The catalytic reaction involves abstraction of two amine protons and two benzylic hydrogen atoms of the metal-bound primary amine by the oxo and hydroxo ligands, respectively. A β-hydride transfer step for the benzylic C-H bond cleavage is not supported by Hammett studies. The nitrile generated by the catalytic oxidation undergoes hydration to afford the amide as the final product. This journal is