2826-26-8

Basic information

• Product Name: TYRPHOSTIN A1
• Synonyms: (4-METHOXYBENZYLIDENE)MALONITRILE;(4-METHOXYBENZYLIDENE)MALONONITRILE;((4-METHOXYPHENYL)METHYLENE)METHANE-1,1-DICARBONITRILE;2-[(4-METHOXYPHENYL)METHYLENE]MALONONITRILE;2-(4-METHOXYBENZYLIDENE)-MALONONITRILE;RARECHEM AL BX 0083;TYRPHOSTIN AG 9;TYRPHOSTIN A1
• CAS NO: 2826-26-8
• Molecular Formula: C₁₁H₈N₂O
• Molecular Weight: 184.19
• Mol File: 2826-26-8.mol
• Article Data: 142

Chemical Properties

• Melting Point: 113-116 °C(lit.)
• Boiling Point: 352.4°Cat760mmHg
• Flash Point: 148.8°C
• Appearance: /
• Density: 1.169g/cm³
• Vapor Pressure: 3.85E-05mmHg at 25°C
• Refractive Index: 1.589
• Storage Temp.: 2-8°C
• Solubility: chloroform: soluble50mg/mL, clear, light yellow
• Sensitive: Light Sensitive
• CAS DataBase Reference: TYRPHOSTIN A1(CAS DataBase Reference)
• NIST Chemistry Reference: TYRPHOSTIN A1(2826-26-8)
• EPA Substance Registry System: TYRPHOSTIN A1(2826-26-8)

Safety Data

• Hazard Codes: Xn
• Statements: 20/21/22
• Safety Statements: 36/37
• RIDADR: UN 3439 6.1/PG III
• WGK Germany: 3
• HazardClass: 6.1
• PackingGroup: III
• Hazardous Substances Data: 2826-26-8(Hazardous Substances Data)

Usage

Chemical Properties

light yellow crystalline needles or crystals

Uses

Tyrphostin A1 is an inactive Tyrphostin used as a negative control for Tyrphostin A23.

Synthesis Reference(s)

Synthetic Communications, 21, p. 1163, 1991 DOI: 10.1080/00397919108021035Synthesis, p. 23, 1970

InChI:InChI=1/C11H8N2O/c1-14-11-4-2-9(3-5-11)6-10(7-12)8-13/h2-6H,1H3

Upstream product

• 141-52-6 sodium ethanolate 
• 123-11-5 4-methoxy-benzaldehyde 
• 109-77-3 malononitrile 
• 14674-38-5 N-(4-methoxybenzylidene)-p-toluenesulfonamide 
• 2700-23-4 4-Nitrobenzylidenemalononitrile 
• 245415-93-4 6-(4-Methoxyphenyl)-1,5-diazabicyclo[3.1.0]hexane 
• 2700-22-3 Benzylidenemalononitrile 
• 2826-32-6 3-nitrobenzylidenemalononitrile 
• 2826-30-4 2-(2-nitrobenzylidene)malononitrile 
• 2826-24-6 4-bromobenzylidenemalononitrile 
• 69527-46-4 5-nitro-2-furfurylidenemalononitrile 
• 6623-89-8 2-oxo-2,3-dihydroindolylidenemalononitrile 
• 894675-39-9 C₁₄H₁₁N₃O 
• 75-15-0 carbon disulfide 

Downstream Products

• 24612-13-3 1.2.2-Tricyan-3-<4-methoxy-phenyl>-cyclopropan-1-carbonsaeure-ethylester 
• 118464-19-0 2-amino-4-(4-methoxyphenyl)-1,4-dihydrobenzo[4,5]imidazolo[1,2-a]pyrimidine-3-carbonitrile 
• 2620-81-7 2-(4-methoxyphenyl)-1H-benzimidazole 
• 150651-38-0 1-Amino-3-(4-methoxy-phenyl)-benzo[4,5]imidazo[1,2-a]pyridine-2,4-dicarbonitrile 
• 79613-20-0 2-[(2'-p-anisyl-1'-cyano)ethen-1'-yl]1H-benzimidazole 
• 77609-14-4 2-ethoxy-4-(4-methoxyphenyl)-6-phenylpyridine-3-carbonitrile 
• 108463-28-1 5-Acetyl-2-amino-4-(4-methoxy-phenyl)-6-oxo-1-phenyl-1,4,5,6-tetrahydro-pyridine-3-carbonitrile 
• 129354-36-5 2-amino-3-cyano-7,7-dimethyl-4-(4-methoxyphenyl)-5-oxo-5,6,7,8-tetrahydro-4H-benzo[b]pyran 
• 75052-59-4 5-amino-2,3-dihydro-7-(4-methoxyphenyl)-2-[(4-methoxyphenyl)methylidene]-3-oxo-7H-thiazolo[3,2-a]pyridine-6,8-dicarbonitrile 
• 145825-97-4 2-Amino-5-(furan-2-carbonyl)-6-mercapto-4-(4-methoxy-phenyl)-4H-thiopyran-3-carbonitrile 
• 128405-20-9 6-(2-Hydroxy-phenyl)-4-(4-methoxy-phenyl)-nicotinonitrile 
• 89809-76-7 ethyl 6-amino-4-(4-methoxyphenyl)-5-cyano-2-methyl-4H-pyran-3-carboxylate 
• 77198-43-7 2-amino-4-(4-methoxyphenyl)-4a,5,6,7-tetrahydronaphthalene-1,3,3(4H)-tricarbonitrile 

Relevant articles and documents

The Knoevenagel condensation catalysed by ionic liquids: a mass spectrometric insight into the reaction mechanism

The creation of carbon-carbon bonds is still a highly required topic in organic chemistry for the capacity to give a wide variety of new products of industrial value. Accordingly, the Knoevenagel condensation between activated methylene compounds and alde

Polyionic liquid decorated chitosan beads as versatile metal-free catalysts for catalyzing chemical reactions in aqueous media

A new strategy is presented for enhancing the catalytic activity of cross-linked chitosan beads. More precisely, chitosan beads were cross linked with glutaraldehyde and then, vinyl functionalized. In the next step, the vinyl-functionalized beads were pol

Highly efficient FeNP-embedded hybrid bifunctional reduced graphene oxide for Knoevenagel condensation with active methylene compounds

We have synthesized atypical highly active bifunctional FeNPs implanted on amino-modified reduced graphene oxide (FeNPs/Am@rGO) [where FeNPs = Fe nanoparticles; Am = Primary aromatic amine derivatives such as p-phenylenediamine (PPD) and/or aniline (AN)]