2840-26-8

Basic information

• Product Name: 3-Amino-4-methoxybenzoic acid
• Synonyms: 3-Aminoanisic acid;5-Carboxy-2-methoxyaniline;LABOTEST-BB LT01138583;3-AMINO-METHOXY BENZOIC ACID;3-Amino-p-anisic acid;3-AMINO-4-ANISIC ACID;3-AMINO-4-METHOXYBENZOIC ACID;3-amino-4-methoxy-benzoicaci
• CAS NO: 2840-26-8
• Molecular Formula: C₈H₉NO₃
• Molecular Weight: 167.16
• EINECS: 220-634-3
• Product Categories: Aromatic Carboxylic Acids, Amides, Anilides, Anhydrides & Salts;Aromatic Amino Acids;Peptide Synthesis;Unnatural Amino Acid Derivatives
• Mol File: 2840-26-8.mol
• Article Data: 4

Chemical Properties

• Melting Point: 208-210 °C(lit.)
• Boiling Point: 295.73°C (rough estimate)
• Flash Point: 166.4 °C
• Appearance: White to light yellow crystal powder
• Density: 1.2917 (rough estimate)
• Vapor Pressure: 1.51E-05mmHg at 25°C
• Refractive Index: 1.5570 (estimate)
• Storage Temp.: Keep in dark place,Inert atmosphere,Room temperature
• PKA: 4.69±0.10(Predicted)
• Water Solubility: Soluble in water.
• CAS DataBase Reference: 3-Amino-4-methoxybenzoic acid(CAS DataBase Reference)
• NIST Chemistry Reference: 3-Amino-4-methoxybenzoic acid(2840-26-8)
• EPA Substance Registry System: 3-Amino-4-methoxybenzoic acid(2840-26-8)

Safety Data

• Hazard Codes: Xi
• Statements: 36/37/38-37/38-36
• Safety Statements: 26-37/39
• WGK Germany: 3
• RTECS: DG2872000
• Hazardous Substances Data: 2840-26-8(Hazardous Substances Data)

Usage

Chemical Properties

White to light yellow crystal powder

Uses

Different sources of media describe the Uses of 2840-26-8 differently. You can refer to the following data:
1. It is an important raw material and intermediate used in organic synthesis, pharmaceuticals, agrochemicals and dyestuffs.
2. 3-Amino-4-methoxybenzoic Acid is a general reactant/reagent used in the synthesis of VEGFR-2 inhibitors. Also used in the preparation of dihydroisoquinoline compounds as tubulin polymerization inhibitors.

InChI:InChI=1/C8H9NO3/c1-12-7-3-2-5(8(10)11)4-6(7)9/h2-4H,9H2,1H3,(H,10,11)/p-1

Upstream product

• 89-41-8 4-methoxy-3-nitrobenzoic acid 
• 24812-90-6 methyl 3-amino-4-methoxybenzoate 
• 7647-01-0 hydrogenchloride 
• 10034-85-2 hydrogen iodide 
• 110-53-2 1-Bromopentane 
• 954815-08-8 3-bromo-4-methoxy-5-nitro-benzoic acid 
• 40757-20-8 methyl 4-methoxy-3-nitrobenzoate 
• 99-58-1 3-bromo-4-methoxybenzoic acid 

Downstream Products

• 66832-25-5 3-((Z)-3-Carboxy-acryloylamino)-4-methoxy-benzoic acid 
• 256935-69-0 N-Fmoc 3-amino-4-methoxy-benzoic acid 
• 148887-46-1 quinoline-8-methoxy-5-carboxylic acid 
• 24812-90-6 methyl 3-amino-4-methoxybenzoate 
• 443291-92-7 2-(4-methoxy-3-aminophenyl)benzothiazole 
• 599201-51-1 2-(3-amino-4-methoxyphenyl)-5-phenylbenzoxazole 
• 931424-04-3 3-{[(Z)-2-amino-1,2-dicyanovinyl]amino}methyleneamino-4-methoxybenzoic acid 
• 113928-90-8 (3-amino-4-methoxyphenyl)methanol 
• 915094-38-1 C₁₀H₈F₃NO₄ 
• 1214266-00-8 (R)-3-(7-cyano-6-ethyl-5-isopropyl-5,6-dihydroimidazo[1,5-f]pteridin-3-ylamino)-4-methoxybenzoic acid 
• 1273072-95-9 3-(5-flouro-4-(2-(methylsulfonamido)phenylamino)pyrimidin-2-ylamino)-4-methoxybenzoic acid 
• 1030576-13-6 C₁₃H₁₇NO₄ 

Relevant articles and documents

Compounds and pharmaceutical use thereof

PCT No. PCT/JP97/00291 Sec. 371 Date Aug. 6, 1998 Sec. 102(e) Date Aug. 6, 1998 PCT Filed Feb. 6, 1997 PCT Pub. No. WO97/29079 PCT Pub. Date Aug. 14, 1997The compounds of the formula (I) wherein each symbol is as defined in the specification, pharmaceutically acceptable salts thereof and pharmaceutical use thereof. The Compound (I) and pharmaceutically acceptable salts thereof of the present invention selectively act on cannabinoid receptors, particularly peripheral receptors, cause less side effects on the central system, and have superior immunoregulating action, antiinflammatory action, antiallergic action and therapeutic effect on nephritis. Therefore, they are useful as cannabinoid receptor, particularly peripheral cannabinoid receptor activators and antagonists, immunoregulators, therapeutic agents for autoimmune diseases, antiinflammatory agents, antiallergic agents and therapeutic agents for nephritis.

A GENERAL PROCEDURE FOR MILD AND RAPID REDUCTION OF ALIPHATIC AND AROMATIC NITRO COMPOUNDS USING AMMONIUM FORMATE AS A CATALYTIC HYDROGEN TRANSFER AGENT

Various aliphatic and aromatic nitro compounds were selectively and rapidly reduced to their corresponding amino derivatives in very good yield using anhydrous ammonium formate as a catalytic hydrogen transfer agent.