284039-94-7

Basic information

• Product Name: 7H-Pyrrolo[2,3-d]pyrimidine-5-carbonitrile, 4-amino-7-[(4-fluorophenyl)methyl]-
• CAS NO: 284039-94-7
• Molecular Formula: C14H10FN5
• Molecular Weight: 267.265
• Mol File: 284039-94-7.mol
• Article Data: 1

Chemical Properties

• CAS DataBase Reference: 7H-Pyrrolo[2,3-d]pyrimidine-5-carbonitrile, 4-amino-7-[(4-fluorophenyl)methyl]-(CAS DataBase Reference)
• NIST Chemistry Reference: 7H-Pyrrolo[2,3-d]pyrimidine-5-carbonitrile, 4-amino-7-[(4-fluorophenyl)methyl]-(284039-94-7)
• EPA Substance Registry System: 7H-Pyrrolo[2,3-d]pyrimidine-5-carbonitrile, 4-amino-7-[(4-fluorophenyl)methyl]-(284039-94-7)

Safety Data

• Hazardous Substances Data: 284039-94-7(Hazardous Substances Data)

Upstream product

• 284040-04-6 4-amino-6-bromo-7-(4-fluorobenzyl)-pyrrolo[2,3-d]pyrimidine-5-carbonitryle 

Relevant articles and documents

Pyrrolo[2,3-d] pyrimidines as antiviral agents

This invention relates to a novel class of 4,5,6,7-substituted non-nucleoside, non-phosphorylatable pyrrolo[2,3-d]pyrimidines which exhibit both significantly lower levels of cytotoxicity and superior antiviral activity than known nucleoside, non-nucleoside, and non-nucleoside, non-phosphorylatable pyrrolo[2,3-d]pyrimidine derivatives, particularly against human DNA viruses such as cytomegalovirus (HCMV) and herpes simplex virus type 1 (HSV-1). These compounds are represented by the following formula: wherein: R4is —NR1R2or oxo; R5is —CN, or —CSNR1R2, or —CONR1R2; R6is —H, or halo, or —NR1R2; wherein R1and R2are independently —H or an aliphatic group; and R7is of the formula R3—Ar, wherein R3is an aliphatic group and Ar is an unsubstituted aryl or an aryl independently substituted with halo, nitro, amino, or aliphatic groups; provided that when R5is a —CN or —CSNH2, and R6is a —H or —NH2, and Ar is a —C6H5or a phenyl substituted with only one aliphatic group, R3is an aliphatic group other than methyl such that —R3— is not a —CH2—; and pharmaceutically acceptable salts, prodrugs and derivatives thereof.