28523-86-6 Usage
Description
Different sources of media describe the Description of 28523-86-6 differently. You can refer to the following data:
1. Sevoflurane is a rapidly acting, potent inhalation anesthetic with rapid uptake and
and elimination. While somewhat less potent than halothane, sevoflurane does not
induce arrhythmias and reportedly has no effect on renal function.
2. Sevoflurane is a halogenated ether with anesthetic properties. It enhances the activity of GABAA and glycine receptors and inhibits the activity of nicotinic acetylcholine receptors (nAChRs) and glutamate receptors. Sevoflurane enhances the responses of α2β1 subunit-containing GABAA and α1 subunit-containing glycine receptors at submaximal agonist concentrations in HEK293 cells (EC50s = 0.45 and 0.36 mM, respectively). Sevoflurane (360 μM) also increases the amplitude of GABAA receptor responses to GABA stimulation for receptors with an α1β2γ2 subunit composition. It inhibits binding of the high affinity nicotinic agonist epibatidine to nAChRs in mouse brain membranes (IC50 = 0.77 mM). Formulations containing sevoflurane have been used in the induction and maintenance of general anesthesia.
Chemical Properties
Clear, colourless, volatile liquid.
Originator
Baxter (USA)
Uses
Different sources of media describe the Uses of 28523-86-6 differently. You can refer to the following data:
1. antibacterial
2. 1,1,1,3,3,3-Hexafluoro-2-(fluoromethoxy)propane is an volatile anesthetic which inhibited activation of inflammatory neutrophil and granulocyte in human blood during simulated extracorporeal circulati
on.
3. Fluoromethyl 1,1,1,3,3,3-hexafluoroisopropyl ether is a volatile anesthetic, which inhibits the activation of inflammatory neutrophil and granulocyte in human blood during simulated extracorporeal circulation. It also serves as an antibacterial and used as an inhalational anaesthetic for induction and maintenance of general anesthesia. Further, it finds application in anesthesia of children and infants to make them asleep for surgery. In addition to this, it is used in veterinary medicine.
Definition
ChEBI: An ether compound having fluoromethyl and 1,1,1,3,3,3-hexafluoroisopropyl as the two alkyl groups.
Manufacturing Process
164 g (2.31 mole) of chlorine is slowly bubbled into a flask containing 370 g
(2.03 mole) of methyl 1,1,1,3,3,3-hexafluoroisopropyl ether illuminated with a
250 watt incandescent lamp, starting at room temperature. The product is
washed with a potassium carbonate solution until neutral, dried over MgSO4
and vacuum distilled to yield 304 g (1.5 mole) of chloromethyl 1,1,1,3,3,3-
hexafluoroisopropyl ether (chloromethyl 1,1,1,3,3,3-hexafluoro-2-propyl
ether), boiling point 78°C.A solution of chloromethyl 1,1,1,3,3,3-hexafluoro-2-propyl ether (754 g, 3.49
moles) in dry tetrahydrothiophene 1,1-dioxide (203 g, 3,49 moles) were stirred
and heated to 130°C in a creased flask fitted with a fractional distillation
assembly. A distillate (200 ml), b748 56.0° to 62°C, was collected during 5 h.
Then the reaction mixture was cooled to room temperature, dry potassium
fluoride (100 g, 1.74 moles) was added, and the cycle of operations was
repeated 3 times at temperatures between 138° to 185°C to give distillates
(100 ml, 100 ml and 50 ml), b746 58° to 61°C, 55.5° to 57°C, and 54.2° to
55.9°C, respectively. From this portionwise addition of potassium fluoride (503
g, 8.7 moles) there was obtained distillates totalling 672 g, b746 54.2° to
62.0°C, which by GLC analysis was about 92% fluoromethyl and 6.8%
chloromethyl 1,1,1,3,3,3-hexafluoro-2-propyl ether.Fractional distillation of 659 g gave a forerun (46 g), b745 53.5° to 57.0°C,
and then 99.6% pure fluoromethyl 1,1,1,3,3,3-hexafluoro-2-propyl ether (505
g), b745 57.0° to 57.7°C.
Brand name
Ultane (Abbott);Sevofrane.
Therapeutic Function
Anesthetic
Biological Functions
Sevoflurane (Ultane) is the most recently introduced inhalation
anesthetic. It has low tissue and blood solubility,
which allows for rapid induction and emergence and
makes it useful for outpatient and ambulatory procedures.
It has the advantage of not being pungent, a characteristic
that permits a smooth inhalation induction,
and is particularly useful in pediatric anesthesia.
Hypotension is produced by sevoflurane as systemic
vasodilation occurs and cardiac output decreases. Since
it does not directly produce tachycardia, it is a useful alternative
to consider in patients with myocardial ischemia.
However, a concern for reflex-induced tachycardia
remains.
Sevoflurane undergoes hepatic biotransformation
(about 3% of the inhaled dose), and it is somewhat degraded
by conventional CO2 absorbents. The degradation
product from the absorbent has been reported to
be nephrotoxic, although the report is controversial and
not substantiated by more recent studies. Sevoflurane’s
actions on skeletal muscle and on vascular regulation
within the CNS are similar to those described for the
other halogenated hydrocarbon anesthetics.
General Description
Sevoflurane is a volatile, nonpungent, nonflammable, andnonexplosive liquid with a boiling point of 58.6°C. Theblood:gas partition coefficient is 0.65, the oil:gas partitioncoefficient is 50, and the MAC is 2.1%. Sevoflurane reactswith desiccated carbon dioxide adsorbents, to produce compounds(A and B) with known toxicity . The typeof CO2 absorbent used, the temperature of the absorbent,and the duration of exposure can influence the degree towhich sevoflurane breaks down. The major breakdownproduct, compound A, pentafluoroisopropenyl fluoromethylether, (PIFE, C4H2F6O) has been studied extensively.Compound A is nephrotoxic in rats and nonhuman primatesand remains a theoretical risk to humans. As discussedpreviously under the stability of inhaled anesthetics,sevoflurane breakdown by CO2 absorbents generates heatand has resulted in sporadic operating room fires.
Clinical Use
Sevoflurane has been shown to cause epileptic changeson EEGs and case reports of seizures during surgery, especiallyin children, have been reported.
Veterinary Drugs and Treatments
Sevoflurane may be useful in a variety of species when rapid induction
and/or rapid recoveries are desired with an inhalational
anesthetic.
Check Digit Verification of cas no
The CAS Registry Mumber 28523-86-6 includes 8 digits separated into 3 groups by hyphens. The first part of the number,starting from the left, has 5 digits, 2,8,5,2 and 3 respectively; the second part has 2 digits, 8 and 6 respectively.
Calculate Digit Verification of CAS Registry Number 28523-86:
(7*2)+(6*8)+(5*5)+(4*2)+(3*3)+(2*8)+(1*6)=126
126 % 10 = 6
So 28523-86-6 is a valid CAS Registry Number.
InChI:InChI=1/C4H3F7O/c5-1-12-2(3(6,7)8)4(9,10)11/h2H,1H2
28523-86-6Relevant articles and documents
Novel green and environment-friendly process applied to sevoflurane production
-
Paragraph 0026-0039, (2022/01/20)
The invention discloses a novel green and environment-friendly process applied to sevoflurane production, which is characterized in that hexafluoroisopropyl methyl ether and fluorine gas are subjected to substitution reaction to generate sevoflurane, and the reaction is carried out in a micro-channel reactor. The process comprises the steps: synchronously pumping hexafluoroisopropyl methyl ether and fluorine gas into two inlets of the microreactor unit through a metering pump respectively; enabling the mixture to pass through a layer of nickel base material and then enter a micro-channel mixer for mixing and reaction; and finally, entering a collecting tank through the nickel base material and an outlet of the microreactor unit. The sevoflurane product produced by the reactor is stable in quality, the production process is green and environment-friendly, the reaction process is easy to control, and the reactor is suitable for industrial production.
Production of fluormethyl 2,2,2-trifluoro-1-(trifluoromethyl)ethyl ether
-
Paragraph 0054, (2015/09/28)
A process for removing water from a mixture comprising hydrogen fluoride and water, said process comprising: a) providing a mixture comprising hydrogen fluoride and water; and b) removing water from the mixture as a constant boiling mixture with hydrogen fluoride.
Manufacture of hexafluoroisopropanol
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Paragraph 0088-0089, (2013/08/28)
Hexafluoroisopropanol (CF3CHOHCF3) is manufactured in two steps from monochloromalonic acid or monochlomalonic acid esters by a reaction with a fluorinating agent, notably SF4, to form CF3CHClCF3 which is hydrolyzed to form CF3CHOHCF3. The hexafluoroisopropanol can be used as such, or, preferably, it is further reacted to form Sevoflurane, an anesthetic. Compounds of the formula CF3-CH(OY)-CF3 wherein Y is OTs, OMe, OTf or OTMS are also described.
