28547-28-6Relevant articles and documents
Imidazole-containing condensed tricyclic compound and application thereof
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Paragraph 0481, (2018/03/01)
The invention discloses an imidazole-containing condensed tricyclic compound adopting the structure as shown in the formula (I) or pharmaceutically acceptable salts, stereisomers or prodrug molecules thereof. The imidazole-containing condensed tricyclic compound has the IDO1 activity regulation function, can enhance T-cell activation through blocking immune checkpoints IDO1, is used for treating IDO1-mediated immunosuppression, and therefore, can become an effective medicine for treating malignant tumors. When used together with checkpoint protein anti-body drugs or other anti-cancer drugs, the imidazole-containing condensed tricyclic compound can enhance the anti-cancer effect. Meanwhile, the imidazole-containing condensed tricyclic compound has the potential of effectively treating IDO1 abnormity related immunosuppressive diseases and has a high application value.
The direct conversion of light into continuous mechanical energy by photoreversible self-assembly: A prototype of a light-powered engine
Masiero, Stefano,Lena, Stefano,Pieraccini, Silvia,Spada, Gian Piero
supporting information; experimental part, p. 3184 - 3187 (2009/02/08)
En route to a clean engine: The concentration of a chemical system containing an azobenzene derivative can be varied cyclically by light, and this variation has been exploited to produce continuous work. The cyclic concentration change of the system is th